Browsing by Author "Chirieac, Lucian"

Now showing items 1-20 of 31

    • Amplification of Chromosomal Segment 4q12 in Non-Small Cell Lung Cancer 

      Ramos, Alex H.; Dutt, Amit; Mermel, Craig; Perner, Sven; Cho, Jeonghee; LaFargue, Christopher J.; Johnson, Laura A.; Stiedl, Ann-Cathrin; Tanaka, Kumiko E.; Bass, Adam; Barretina, Jordi; Weir, Barbara A.; Beroukhim, Rameen; Thomas, Roman K.; Minna, John D.; Chirieac, Lucian; Lindeman, Neal; Giordano, Thomas J.; Beer, David G.; Wagner, Patrick; Wistuba, Ignacio I.; Rubin, Mark A.; Meyerson, Matthew (Informa UK Limited, 2009-11-01)
      In cancer, proto-oncogenes are often altered by genomic amplification. Here we report recurrent focal amplifications of chromosomal segment 4q12 overlapping the proto-oncogenes PDGFRA and KIT in non-small cell lung cancer ...

    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models 

      Li, D; Ambrogio, L; Shimamura, T; Kubo, S; Takahashi, M; Chirieac, Lucian; Padera, Robert; Shapiro, Geoffrey; Baum, A; Himmelsbach, F; Rettig, W J; Meyerson, Matthew; Solca, F; Greulich, Heidi; Wong, K-K (Springer Science and Business Media LLC, 2008-04-14)
      Genetic alterations in the kinase domain of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to treatment with small molecule tyrosine kinase ...

    • The Biology and Treatment of EML4-ALK Non-Small Cell Lung Cancer 

      Sasaki, Takaaki; Rodig, Scott; Chirieac, Lucian; Janne, Pasi (Elsevier BV, 2010-07)
      The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often ...

    • Characterizing the Cancer Genome in Lung Adenocarcinoma 

      Weir, Barbara A.; Woo, Michele S.; Getz, Gad; Perner, Sven; Ding, Li; Beroukhim, Rameen; Lin, William; Province, Michael A.; Kraja, Aldi T.; Johnson, Laura A.; Shah, Kinjal; Sato, Mitsuo; Thomas, Roman K.; Barletta, Justine; Borecki, Ingrid B.; Broderick, Stephen; Chang, Andrew C.; Chiang, Derek Y.; Chirieac, Lucian; Cho, Jeonghee; Fujii, Yoshitaka; Gazdar, Adi F.; Giordano, Thomas J.; Greulich, Heidi; Hanna, Megan; Johnson, Bruce; Kris, Mark G.; Lash, Alex; Lin, Ling; Lindeman, Neal; Mardis, Elaine R.; McPherson, John D.; Minna, John D.; Morgan, Margaret B.; Nadel, Mark; Orringer, Mark B.; Osborne, John R.; Ozenberger, Brad; Ramos, Alex H.; Robinson, James; Roth, Jack A.; Rusch, Valerie; Sasaki, Hidefumi; Shepherd, Frances A.; Sougnez, Carrie; Spitz, Margaret R.; Tsao, Ming-Sound; Twomey, David; Verhaak, Roel G. W.; Weinstock, George; Wheeler, David A.; Winckler, Wendy; Yoshizawa, Akihiko; Yu, Soyoung; Zakowski, Maureen F.; Zhang, Qunyuan; Beer, David G.; Wistuba, Ignacio I.; Watson, Mark A.; Garraway, Levi A.; Ladanyi, Marc; Travis, William D.; Pao, William; Rubin, Mark A; Gabriel, Stacey; Gibbs, Richard A.; Varmus, Harold E.; Wilson, Richard K.; Lander, Eric; Meyerson, Matthew (Springer Science and Business Media LLC, 2007-12-06)
      Somatic alterations in cellular DNA underlie almost all human cancers1. The prospect of targeted therapies2 and the development of high-resolution, genome-wide approaches3–8 are now spurring systematic efforts to characterize ...

    • Collagen XXIII: A Potential Biomarker for the Detection of Primary and Recurrent Non–Small Cell Lung Cancer 

      Spivey, Kristin A.; Banyard, Jacqueline; Solis, Luisa M.; Wistuba, Ignacio I.; Barletta, Justine; Gandhi, Leena; Feldman, Henry; Rodig, Scott; Chirieac, Lucian; Zetter, Bruce (American Association for Cancer Research (AACR), 2010-05)
      Background Collagen XXIII is a transmembrane collagen previously shown to be upregulated in metastatic prostate cancer. This study’s purpose was to determine the protein expression of collagen XXIII in tumor tissues from ...

    • Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas 

      Sholl, Lynette Marie; Weremowicz, Stanislawa; Gray, Stacy; Wong, Kwok-Kin; Chirieac, Lucian Radu; Lindeman, Neal I.; Hornick, Jason L. (Elsevier BV, 2013)
      INTRODUCTION ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK overexpression and predicting response to targeted therapy. Fluorescence in situ hybridization (FISH) is the gold standard ...

    • Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR) 

      Churg, Andrew; Attanoos, Richard; Borczuk, Alain C.; Chirieac, Lucian; Galateau-Sallé, Françoise; Gibbs, Allen; Henderson, Douglas; Roggli, Victor; Rusch, Valerie; Judge, Meagan J.; Srigley, John R. (Archives of Pathology and Laboratory Medicine, 2016-10)
      Context The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, ...

    • Epidermal Growth Factor Receptor Gene Amplification in Atypical Adenomatous Hyperplasia of the Lung 

      McIntire, Maria G.; Santagata, Sandro; Ligon, Keith; Chirieac, Lucian (e-Century Publishing, 2010-05-16)
      Atypical adenomatous hyperplasia (AAH) is postulated to be the earliest morphologic precursor lesion in lung carcinogenesis. The epidermal growth factor receptor (EGFR), one of the members of the Erb-2 family of receptors, ...

    • Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma 

      Suehiro, Yutaka; Wong, Chi Wai; Chirieac, Lucian; Kondo, Yutaka; Shen, Lanlan; Webb, C. Renee; Chan, Yee Wai; Chan, Annie S.Y.; Chan, Tsun Leung; Wu, Tsung-Teh; Rashid, Asif; Hamanaka, Yuichiro; Hinoda, Yuji; Shannon, Rhonda L.; Wang, Xuemei; Morris, Jeffrey; Issa, Jean-Pierre J.; Yuen, Siu Tsan; Leung, Suet Yi; Hamilton, Stanley R. (American Association for Cancer Research (AACR), 2008-05-01)
      Purpose Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O6-methylguanine DNA methyltransferase ...

    • Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry 

      Kluk, Michael J.; Ashworth, Todd; Wang, Hongfang; Knoechel, Birgit; Mason, Emily F.; Morgan, Elizabeth A.; Dorfman, David; Pinkus, Geraldine; Weigert, Oliver; Hornick, Jason L.; Chirieac, Lucian R.; Hirsch, Michelle; Oh, David J.; South, Andrew P.; Leigh, Irene M.; Pourreyron, Celine; Cassidy, Andrew J.; DeAngelo, Daniel J.; Weinstock, David M.; Krop, Ian E.; Dillon, Deborah; Brock, Jane E.; Lazar, Alexander J. F.; Peto, Myron; Cho, Raymond J.; Stoeck, Alexander; Haines, Brian B.; Sathayanrayanan, Sriram; Rodig, Scott; Aster, Jon C. (Public Library of Science, 2013)
      Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been ...

    • Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma 

      De Rienzo, Assunta; Archer, Michael A.; Yeap, Beow; Dao, Nhien; Sciaranghella, Daniele; Sideris, Antonios C.; Zheng, Yifan; Holman, Alexander G.; Wang, Yaoyu E.; Dal Cin, Paola; Fletcher, Jonathan; Rubio, Renee; Croft, Larry; Quackenbush, John; Sugarbaker, Peter E.; Munir, Kiara J.; Battilana, Jesse R.; Gustafson, Corinne; Chirieac, Lucian; Ching, Soo Meng; Wong, James; Tay, Liang Chung; Rudd, Stephen; Hercus, Robert; Sugarbaker, David J.; Richards, William; Bueno, Raphael (American Association for Cancer Research (AACR), 2016-01-15)
      Malignant pleural mesothelioma (MPM) is an aggressive cancer that occurs more frequently in men, but is associated with longer survival in women. Insight into the survival advantage of female patients may advance the ...

    • Genome-Wide Analysis of Survival in Early-Stage Non–Small-Cell Lung Cancer 

      Huang, Yen-Tsung; Suk Heist, Rebecca; Chirieac, Lucian; Lin, Xihong; Skaug, Vidar; Zienolddiny, Shanbeh; Haugen, Aage; Wu, Michael C.; Wang, Zhaoxi; Su, Li; Asomaning, Kofi; Christiani, David (American Society of Clinical Oncology (ASCO), 2009-06-01)
      Purpose Lung cancer, of which 85% is non–small-cell (NSCLC), is the leading cause of cancer-related death in the United States. We used genome-wide analysis of tumor tissue to investigate whether single nucleotide ...

    • Identification of Metastatic Nodal Disease in a Phase 1 Dose-Escalation Trial of Intraoperative Sentinel Lymph Node Mapping in Non–small Cell Lung Cancer Using Near-Infrared Imaging 

      Gilmore, Denis M.; Khullar, Onkar V.; Jaklitsch, Michael; Chirieac, Lucian; Frangioni, John V.; Colson, Yolonda (Elsevier BV, 2013-09)
      Objectives Early stage non-small cell lung cancer (NSCLC) has a high recurrence rate and poor 5-yearsurvival, particularly if lymph nodes are involved. Our objective was to perform a dose escalationstudy to assess safety ...

    • Immunohistochemical Markers Associated With Brain Metastases in Patients with Nonsmall Cell Lung Carcinoma 

      Saad, Ali G.; Yeap, Beow; Thunnissen, Frederik B. J. M.; Pinkus, Geraldine; Pinkus, Jack; Loda, Massimo; Sugarbaker, David J.; Johnson, Bruce; Chirieac, Lucian (Wiley, 2008-10-15)
      BACKGROUND There are no reliable markers able to identify patients with non-small cell lung cancer (NSCLC) likely to metastasize to the brain. We investigated associations between immunohistochemical markers and development ...

    • Lung Adenocarcinoma with EGFR Amplification Has Distinct Clinicopathologic and Molecular Features in Never-Smokers 

      Sholl, Lynette Marie; Yeap, Beow Yong; Iafrate, Anthony John; Holmes-Tisch, A. J.; Chou, Y.-P.; Wu, Ming-Tsang; Goan, Y.-G.; Su, Li; Benedettini, E.; Yu, J.; Loda, Massimo; Janne, Pasi Antero; Christiani, David Christopher; Chirieac, Lucian Radu (American Association for Cancer Research (AACR), 2009)
      In a subset of lung adenocarcinomas the epidermal growth factor receptor (EGFR) is activated by kinase domain mutations and/or gene amplification, but the interaction between the two types of abnormalities is complex and ...

    • Novel Mutant-Selective EGFR Kinase Inhibitors Against EGFR T790M 

      Zhou, Wenjun; Ercan, Dalia; Chen, Liang; Yun, Cai-Hong; Li, Danan; Capelletti, Marzia; Cortot, Alexis; Chirieac, Lucian; Iacob, Roxana E.; Padera, Robert; Engen, John R.; Wong, Kwok-Kin; Eck, Michael; Gray, Nathanael S.; Janne, Pasi (Springer Science and Business Media LLC, 2009-12-24)
      The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors in EGFR-mutant non-small-cell lung cancer (NSCLC) is limited by the development of drug-resistance mutations, including the gatekeeper T790M ...

    • A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-rearranged Lung Adenocarcinomas by Standard Immunohistochemistry 

      Mino-Kenudson, Mari; Chirieac, Lucian; Law, Kenny; Hornick, Jason; Lindeman, Neal; Mark, Eugene; Cohen, David W.; Johnson, Bruce; Janne, Pasi; Iafrate, Anthony; Rodig, Scott (American Association for Cancer Research, 2010-03)
      Purpose Approximately 5% of lung adenocarcinomas harbor an EML4-ALK gene fusion and define a unique tumor group that may be responsive to targeted therapy. However ALK-rearranged lung adenocarcinomas are difficult to ...

    • Phase II Trial of the Histone Deacetylase Inhibitor Romidepsin in Patients With Recurrent/Metastatic Head and Neck Cancer 

      Haigentz, Missak; Kim, Mimi; Sarta, Catherine; Lin, Juan; Keresztes, Roger S.; Culliney, Bruce; Gaba, Anu G.; Smith, Richard V.; Shapiro, Geoffrey; Chirieac, Lucian; Mariadason, John M.; Belbin, Thomas J.; Greally, John M.; Wright, John J.; Haddad, Robert (Elsevier BV, 2012-12)
      Objectives Patients with advanced squamous cell carcinoma of the head and neck (SCCHN) have limited treatment options. Inhibition of histone deacetylases (HDACs) represents a novel therapeutic approach warranting additional ...

    • The Prognostic Significance of Grading in Lung Adenocarcinoma 

      Barletta, Justine; Yeap, Beow; Chirieac, Lucian (2010-02-01)
      Background Although grading has prognostic significance for many tumor types, a prognostically significant grading system for lung adenocarcinoma has not yet been established. The aim of this study was to evaluate histologic ...

    • Regression of Drug-Resistant Lung Cancer by the Combination of Rosiglitazone and Carboplatin 

      Girnun, Geoffrey D.; Chen, Liang; Silvaggi, Jessica; Drapkin, Ronny; Chirieac, Lucian; Padera, Robert; Upadhyay, Rabi; Vafai, Scott B; Weissleder, Ralph; Mahmood, Umar; Naseri, Elnaz; Buckley, Stephanie; Li, Danan; Force, Jeremy; McNamara, Kate; Demetri, George; Spiegelman, Bruce; Wong, Kwok-Kin (American Association for Cancer Research (AACR), 2008-10-15)
      Purpose Current therapy for lung cancer involves multimodality therapies. However, many patients are either refractory to therapy or develop drug resistance. KRAS and epidermal growth factor receptor (EGFR) mutations ...