Browsing by Author "Kaczmarek, Elzbieta"

Now showing items 1-4 of 4

    • Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via G\(_{i}\) and Akt-Dependent Actin Cytoskeleton Remodeling 

      Siddaramappa Umapathy, Nagavedi; Kaczmarek, Elzbieta; Fatteh, Nooreen; Burns, Nana; Lucas, Rudolf; Stenmark, Kurt R.; Verin, Alexander D.; Gerasimovskaya, Evgenia V. (Public Library of Science, 2013)
      Background: In a neonatal model of hypoxic pulmonary hypertension, a dramatic pulmonary artery adventitial thickening, accumulation of inflammatory cells in the adventitial compartment, and angiogenic expansion of the vasa ...

    • Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps 

      Itagaki, Kiyoshi; Kaczmarek, Elzbieta; Lee, Yen Ting; Tang, I. Tien; Isal, Burak; Adibnia, Yashar; Sandler, Nicola; Grimm, Melissa J.; Segal, Brahm H.; Otterbein, Leo E.; Hauser, Carl J. (Public Library of Science, 2015)
      Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial damage-associated molecular patterns (mtDAMPs), including mitochondrial ...

    • Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea 

      Kaczmarek, Elzbieta; Bakker, Jessie P.; Clarke, Douglas N.; Csizmadia, Eva; Kocher, Olivier; Veves, Aristidis; Tecilazich, Francesco; O'Donnell, Christopher P.; Ferran, Christiane; Malhotra, Atul (Public Library of Science, 2013)
      Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ...

    • O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice 

      Shrikhande, Gautam V.; Scali, Salvatore T.; Csizmadia, Eva; Matthey, Michaela; Arjoon, Roy; Patel, Rakesh; Maccariello, Elizabeth R.; Andersen, Nicholas D.; Monahan, Thomas; Studer, Peter; Padilha Guedes, Renata; Usheva, Anny; Da Silva, Cleide Gonsalves; Damrauer, Scott Michael; Putheti, Prabhakar; Siracuse, Jeffrey Joseph; Peterson, Clayton Ross; Essayagh, Sanah; Kocher, Olivier Nicolas; Veves, Aristidis; Kaczmarek, Elzbieta; Ferran, Christiane (Public Library of Science, 2010)
      Background: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). ...