Browsing by Author "Mihm, Martin"

Now showing items 1-7 of 7

    • Alpha-CTLA-4 mAb-associated Panenteritis: A Histologic and Immunohistochemical Analysis 

      Oble, Darryl A.; Mino-Kenudson, Mari; Goldsmith, Jeffrey David; Hodi, Frank Stephen; Seliem, Rania M.; Dranoff, Glenn; Mihm, Martin Charles; Hasserjian, Robert Paul; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. ...

    • Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses 

      Pawlak, Amanda C.; Cosper, Arjola K.; Deng, April; Horick, Nora K.; Le, Long Phi; Dias-Santagata, Dora; Selim, M. Angelica; Iafrate, Anthony John; Hoang, Mai P; Mihm, Martin Charles; Nguyen, Anh Thu (Public Library of Science, 2012)
      Apocrine-eccrine carcinomas are rare and associated with poor prognosis. Currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional ...

    • Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors 

      Lezcano, Cecilia; Lee, Chung-Wei; Larson, Allison R.; Menzies, Alexander M.; Kefford, Richard F.; Thompson, John F.; Mihm, Martin C.; Ogino, Shuji; Long, Georgina V.; Scolyer, Richard A.; Murphy, George F. (2013)
      Of more than 150,000 published studies evaluating new biomarkers, fewer than 100 biomarkers have been implemented for patient care[1]. One reason for this is lack of rigorous testing by the medical community to validate ...

    • Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”: Napoli, December 3rd–6th 2014 

      Ascierto, Paolo A.; Atkins, Michael; Bifulco, Carlo; Botti, Gerardo; Cochran, Alistair; Davies, Michael; Demaria, Sandra; Dummer, Reinhard; Ferrone, Soldano; Formenti, Silvia; Gajewski, Thomas F.; Garbe, Claus; Khleif, Samir; Kiessling, Rolf; Lo, Roger; Lorigan, Paul; Arthur, Grant Mc; Masucci, Giuseppe; Melero, Ignacio; Mihm, Martin; Palmieri, Giuseppe; Parmiani, Giorgio; Puzanov, Igor; Romero, Pedro; Schilling, Bastian; Seliger, Barbara; Stroncek, David; Taube, Janis; Tomei, Sara; Zarour, Hassane M.; Testori, Alessandro; Wang, Ena; Galon, Jérôme; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M.; Thurin, Magdalena (BioMed Central, 2015)
      The fourth “Melanoma Bridge Meeting” took place in Naples, December 3–6th, 2014. The four topics discussed at this meeting were: Molecular and Immunological Advances, Combination Therapies, News in Immunotherapy, and Tumor ...

    • Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors 

      Larson, Allison R.; Dresser, Karen; Zhan, Qian; Lezcano, Cecilia; Woda, Bruce A.; Yosufi, Benafsha; Thompson, John F.; Scolyer, Richard A.; Mihm, Martin C.; Shi, Yujiang G.; Murphy, George F.; Lian, Christine Guo (2013)
      DNA methylation is the most well studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We ...

    • Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma 

      Lee, Jonathan J.; Cook, Martin; Mihm, Martin C.; Xu, Shuyun; Zhan, Qian; Wang, Thomas J.; Murphy, George F.; Lian, Christine G. (Impact Journals LLC, 2015)
      Melanomas in the vertical growth phase (VGP) not infrequently demonstrate cellular heterogeneity. One commonly encountered subpopulation displays small cell/nevoid morphology. Although its significance remains unknown, ...

    • Novel Genetic Mutations in a Sporadic Port-Wine Stain 

      Lian, Christine Guo; Sholl, Lynette Marie; Zakka, Labib; O, Teresa M.; Liu, Cynthia; Xu, Shuyun; Stanek, Ewelina; Garcia, Elizabeth; Jia, Yonghui; MacConaill, Laura Eleanor; Murphy, George Francis; Waner, Milton; Mihm, Martin Charles (American Medical Association (AMA), 2014)
      Importance Port-wine stains (PWSs) are common congenital cutaneous capillary malformations. A somatic GNAQ mutation was recently identified in patients with sporadic PWSs and Sturge-Weber syndrome. However, subsequent ...