Browsing by Author "Poduri, Annapurna"
Now showing items 1-6 of 6
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Comparison of Drug Utilization Patterns in Observational Data: Antiepileptic Drugs in Pediatric Patients
Bourgeois, Florence Tanya; Olson, Karen Lea; Poduri, Annapurna; Mandl, Kenneth David (Springer Nature, 2015)Purpose: Physicians require information on the comparative benefits and harms of medications for optimal treatment decisions. However, this type of data is limited, especially for pediatric patients. Objective: Our aim ... -
Microarray Noninvasive Neuronal Seizure Recordings from Intact Larval Zebrafish
Meyer, Michaela; Dhamne, Sameer C.; LaCoursiere, Christopher M.; Tambunan, Dimira; Poduri, Annapurna; Rotenberg, Alexander (Public Library of Science, 2016)Zebrafish epilepsy models are emerging tools in experimental epilepsy. Zebrafish larvae, in particular, are advantageous because they can be easily genetically altered and used for developmental and drug studies since ... -
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures
Stödberg, Tommy; McTague, Amy; Ruiz, Arnaud J.; Hirata, Hiromi; Zhen, Juan; Long, Philip; Farabella, Irene; Meyer, Esther; Kawahara, Atsuo; Vassallo, Grace; Stivaros, Stavros M.; Bjursell, Magnus K.; Stranneheim, Henrik; Tigerschiöld, Stephanie; Persson, Bengt; Bangash, Iftikhar; Das, Krishna; Hughes, Deborah; Lesko, Nicole; Lundeberg, Joakim; Scott, Rod C.; Poduri, Annapurna; Scheffer, Ingrid E.; Smith, Holly; Gissen, Paul; Schorge, Stephanie; Reith, Maarten E. A.; Topf, Maya; Kullmann, Dimitri M.; Harvey, Robert J.; Wedell, Anna; Kurian, Manju A. (Nature Pub. Group, 2015)The potassium-chloride co-transporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintaining a hyperpolarizing gradient for chloride ions. KCC2 dysfunction has been implicated in human ... -
Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain
Cai, Xuyu; Evrony, Gilad D.; Lehmann, Hillel S.; Elhosary, Princess C.; Mehta, Bhaven K.; Poduri, Annapurna; Walsh, Christopher A. (2014)SUMMARY De novo copy-number variants (CNVs) can cause neuropsychiatric disease, but the degree to which they occur somatically, and during development, is unknown. Single-cell whole-genome sequencing (WGS) in >200 single ... -
Trends in Resource Utilization by Children with Neurological Impairment in the United States Inpatient Health Care System: A Repeat Cross-Sectional Study
Berry, Jay Griffin; Poduri, Annapurna; Bonkowsky, Joshua L.; Zhou, Jing; Graham, Dionne Alicbusan; Welch, Chelsea; Putney, Heather; Srivastava, Rajendu (Public Library of Science, 2012)Jay Berry and colleagues report findings from an analysis of hospitalization data in the US, examining the proportion of inpatient resources attributable to care for children with neurological impairment. -
Two Stories of Neurodevelopment: Exosome-Mediated Secretion of Sonic Hedgehog and Somatic Mutation in Disorders of DNA Damage Repair
Coulter, Michael (2016-09-06)Human genetics of neonatal brain malformations has identified dozens of genes required for brain development that regulate diverse cellular processes. Recent evidence shows that somatic mutations, mutations that are only ...