Browsing by Author "Liefke, Robert"
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The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells
Liefke, Robert; Windhof-Jaidhauser, Indra M.; Gaedcke, Jochen; Salinas-Riester, Gabriela; Wu, Feizhen; Ghadimi, Michael; Dango, Sebastian (BioMed Central, 2015)Background: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. ... -
The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells
Liefke, Robert; Shi, Yang (Nature Publishing Group, 2015)CpG islands (CGIs) are key DNA regulatory elements in the vertebrate genome and are often found at gene promoters. In mammalian embryonic stem (ES) cells, CGIs are decorated by either the active or repressive histone marks, ...