Browsing by Author "Weinberger, Ariel"

Now showing items 1-4 of 4

    • Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals 

      Rast, Luke I.; Rouzine, Igor M.; Rozhnova, Ganna; Bishop, Lisa; Weinberger, Ariel D.; Weinberger, Leor S. (Public Library of Science, 2016)
      The rapid evolution of RNA-encoded viruses such as HIV presents a major barrier to infectious disease control using conventional pharmaceuticals and vaccines. Previously, it was proposed that defective interfering particles ...

    • CRISPR-Cas: To Take Up DNA or Not—That Is the Question 

      Weinberger, Ariel D; Gilmore, Michael S. (Elsevier BV, 2012)
      Historically landmark experiments showed that capsule switching is critical for Streptococcus pneumonia survival. Further studies demonstrated that capsule ‘transformation’ occurs via DNA uptake. In this issue of Cell Host ...

    • Persisting Viral Sequences Shape Microbial CRISPR-Based Immunity 

      Weinberger, Ariel D; Sun, Christine L.; Pluciński, Mateusz M.; Denef, Vincent J.; Thomas, Brian C.; Horvath, Philippe; Barrangou, Rodolphe; Gilmore, Michael S.; Getz, Wayne M.; Banfield, Jillian F. (Public Library of Science, 2012)
      Well-studied innate immune systems exist throughout bacteria and archaea, but a more recently discovered genomic locus may offer prokaryotes surprising immunological adaptability. Mediated by a cassette-like genomic locus ...

    • Viral Diversity Threshold for Adaptive Immunity in Prokaryotes 

      Weinberger, Ariel D; Wolf, Yuri I.; Lobkovsky, Alexander E.; Gilmore, Michael S.; Koonin, Eugene V. (American Society for Microbiology, 2012)
      Bacteria and archaea face continual onslaughts of rapidly diversifying viruses and plasmids. Many prokaryotes maintain adaptive immune systems known as clustered regularly interspaced short palindromic repeats (CRISPR) and ...