Browsing by Author "Bry, Lynn"

Now showing items 1-10 of 10

    • Alterations of the human gut microbiome in multiple sclerosis 

      Jangi, Sushrut; Gandhi, Roopali; Cox, Laura M.; Li, Ning; von Glehn, Felipe; Yan, Raymond; Patel, Bonny; Mazzola, Maria Antonietta; Liu, Shirong; Glanz, Bonnie L.; Cook, Sandra; Tankou, Stephanie; Stuart, Fiona; Melo, Kirsy; Nejad, Parham; Smith, Kathleen; Topçuolu, Begüm D.; Holden, James; Kivisäkk, Pia; Chitnis, Tanuja; De Jager, Philip L.; Quintana, Francisco J.; Gerber, Georg K.; Bry, Lynn; Weiner, Howard L. (Nature Publishing Group, 2016)
      The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis ...

    • The business of genomic testing: a survey of early adopters 

      Crawford, James M.; Bry, Lynn; Pfeifer, John; Caughron, Samuel K.; Black-Schaffer, Stephen; Kant, Jeffrey A.; Kaufman, Jill H. (Nature Publishing Group, 2014)
      Purpose: The practice of “genomic” (or “personalized”) medicine requires the availability of appropriate diagnostic testing. Our study objective was to identify the reasons for health systems to bring next-generation ...

    • Dynamics of the Microbiota in Response to Host Infection 

      Belzer, Clara; Gerber, Georg K.; Roeselers, Guus; Delaney, Mary; DuBois, Andrea; Liu, Qing; Belavusava, Vera; Yeliseyev, Vladimir; Houseman, Andres; Onderdonk, Andrew; Cavanaugh, Colleen; Bry, Lynn (Public Library of Science, 2014)
      Longitudinal studies of the microbiota are important for discovering changes in microbial communities that affect the host. The complexity of these ecosystems requires rigorous integrated experimental and computational ...

    • Genomically Informed Surveillance for Carbapenem-Resistant Enterobacteriaceae in a Health Care System 

      Pecora, Nicole D.; Li, Ning; Allard, Marc; Li, Cong; Albano, Esperanza; Delaney, Mary; Dubois, Andrea; Onderdonk, Andrew B.; Bry, Lynn (American Society of Microbiology, 2015)
      ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health concern. Rapid identification of the resistance genes, their mobilization capacity, and strains carrying them is essential to direct hospital ...

    • Implementation of Electronic Consent at a Biobank: An Opportunity for Precision Medicine Research 

      Boutin, Natalie T.; Mathieu, Kathleen; Hoffnagle, Alison G.; Allen, Nicole L.; Castro, Victor M.; Morash, Megan; O’Rourke, P. Pearl; Hohmann, Elizabeth L.; Herring, Neil; Bry, Lynn; Slaugenhaupt, Susan A.; Karlson, Elizabeth W.; Weiss, Scott T.; Smoller, Jordan W. (MDPI, 2016)
      The purpose of this study is to characterize the potential benefits and challenges of electronic informed consent (eIC) as a strategy for rapidly expanding the reach of large biobanks while reducing costs and potentially ...

    • Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics 

      Yaung, Stephanie J; Deng, Luxue; Li, Ning; Braff, Jonathan L; Church, George M; Bry, Lynn; Wang, Harris H; Gerber, Georg K (BlackWell Publishing Ltd, 2015)
      Elucidating functions of commensal microbial genes in the mammalian gut is challenging because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. We present Temporal FUnctional Metagenomics ...

    • Inferring Dynamic Signatures of Microbes in Complex Host Ecosystems 

      Gerber, Georg Kurt; Onderdonk, Andrew Bruce; Bry, Lynn (Public Library of Science, 2012)
      The human gut microbiota comprise a complex and dynamic ecosystem that profoundly affects host development and physiology. Standard approaches for analyzing time-series data of the microbiota involve computation of measures ...

    • Maternal intestinal flora and wheeze in early childhood 

      Lange, Nancy; Celedón, Juan C.; Forno, Erick; Ly, Ngoc P.; Onderdonk, Andrew Bruce; Bry, Lynn; Delaney, Mary Louise Rodriguez; DuBois, Andrea M.; Gold, Diane R.; Weiss, Scott Tillman; Litonjua, Augusto Ampil (Wiley-Blackwell, 2011)
      Background: Increasing evidence links altered intestinal flora in infancy to eczema and asthma. No studies have investigated the influence of maternal intestinal flora on wheezing and eczema in early childhood. Objective: To ...

    • MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses 

      Bucci, Vanni; Tzen, Belinda; Li, Ning; Simmons, Matt; Tanoue, Takeshi; Bogart, Elijah; Deng, Luxue; Yeliseyev, Vladimir; Delaney, Mary L.; Liu, Qing; Olle, Bernat; Stein, Richard R.; Honda, Kenya; Bry, Lynn; Gerber, Georg K. (BioMed Central, 2016)
      Predicting dynamics of host-microbial ecosystems is crucial for the rational design of bacteriotherapies. We present MDSINE, a suite of algorithms for inferring dynamical systems models from microbiome time-series data and ...

    • Thymus-derived regulatory T cells control tolerance to commensal microbiota 

      Cebula, Anna; Seweryn, Michal; Rempala, Grzegorz A.; Pabla, Simarjot Singh; McIndoe, Richard A.; Denning, Timothy L.; Bry, Lynn; Kraj, Piotr; Kisielow, Pawel; Ignatowicz, Leszek (2013)
      Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal microbiota involve CD4+Foxp3+ regulatory T cells1,2 generated in the thymus (tTregs) or extrathymically by induction of naive CD4+Foxp3− ...