Browsing by Author "Krolewski, Andrzej"
Now showing items 1-14 of 14
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Confirmation of Genetic Associations at ELMO1 in the GoKinD Collection Supports Its Role as a Susceptibility Gene in Diabetic Nephropathy
Pezzolesi, Marcus Guy; Katavetin, Pisut; Kure, Masahiko; Poznik, G. David; Skupien, Jan Krzysztof; Mychaleckyj, Josyf C.; Rich, Stephen S.; Warram, James H.; Krolewski, Andrzej Stefan (American Diabetes Association, 2009)Objective: To examine the association between single nucleotide polymorphisms (SNPs) in the engulfment and cell motility 1 (ELMO1) gene, a locus previously shown to be associated with diabetic nephropathy in two ethnically ... -
The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end stage renal disease
Skupien, Jan; Warram, James H.; Smiles, Adam M.; Niewczas, Monika Anna; Gohda, Tomohito; Pezzolesi, Marcus Guy; Cantarovich, Diego; Stanton, Robert Carl; Krolewski, Andrzej Stefan (2012)The risk of end-stage renal disease (ESRD) remains high in patients with type 1diabetes and proteinuria; however, little is known about the rate of decline in their renal function. To help determine this we enrolled patients ... -
Elevation of circulating TNF receptors 1 and 2 increases the risk of end-stage renal disease in American Indians with type 2 diabetes
PAVKOV, MEDA E.; NELSON, ROBERT G.; KNOWLER, WILLIAM C.; CHENG, YILING; KROLEWSKI, ANDRZEJ S.; NIEWCZAS, MONIKA A. (2014)In Caucasians with type 2 diabetes, circulating TNF receptors 1 (TNFR1) and 2 (TNFR2) predict end-stage renal disease (ESRD). Here we examined this relationship in a longitudinal cohort study of American Indians with type ... -
Exclusion of Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) as a Cause of Diabetic Nephropathy in Type 1 Diabetes
Wanic, Krzysztof; Placha, Grzegorz; Dunn, Jonathon; Smiles, Adam; Warram, James H.; Krolewski, Andrzej Stefan (American Diabetes Association, 2008)Objectives: Recently, an association was found between diabetic nephropathy and the D18S880 microsatellite, located in the carnosinase gene (CNDP1) on chromosome 18q. Alleles of this microsatellite encode for a variable ... -
Family-Based Association Analysis Confirms the Role of the Chromosome 9q21.32 Locus in the Susceptibility of Diabetic Nephropathy
Pezzolesi, Marcus Guy; Jeong, Jackson; Smiles, Adam M.; Skupien, Jan; Mychaleckyj, Josyf C.; Rich, Stephen S.; Warram, James H.; Krolewski, Andrzej Stefan (Public Library of Science, 2013)A genome-wide association scan of type 1 diabetic patients from the GoKinD collections previously identified four novel diabetic nephropathy susceptibility loci that have subsequently been shown to be associated with ... -
Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes
Poznik, G. David; Mychaleckyj, Josyf C.; Barati, Michelle T.; Klein, Jon B.; Ng, Daniel P.K.; Placha, Grzegorz; Canani, Luis H.; Bochenski, Jacek; Waggott, Daryl; Merchant, Michael L.; Mirea, Lucia; Wanic, Krzysztof; Katavetin, Pisut; Kure, Masahiko; Wolkow, Pawel; Dunn, Jonathon S.; Smiles, Adam; Boright, Andrew P.; Bull, Shelley B.; Rich, Stephen S.; Warram, James H.; Pezzolesi, Marcus Guy; Paterson, Andrew D.; Krolewski, Bozena Krystyna; DCCT/EDIC Research Group; Krolewski, Andrzej Stefan; Walker, William H.; Doria, Alessandro; Rogus, John Joseph (American Diabetes Association, 2009)OBJECTIVE—Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of susceptibility genes and their variants has had limited success. To search for genes that contribute to ... -
High-Density Single Nucleotide Polymorphism Genome-Wide Linkage Scan for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes
Poznik, G. David; Smiles, Adam M.; Dunn, Jonathon; Wanic, Krzysztof; Moczulski, Dariusz; Canani, Luis; Araki, Shinichi; Makita, Yuichiro; Warram, James H.; Rogus, John Joseph; Pezzolesi, Marcus Guy; Walker, William; Krolewski, Andrzej Stefan (American Diabetes Association, 2008)Objective: Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) ... -
Increased plasma Kidney Injury Molecule-1 suggests early progressive renal decline in non-proteinuric patients with Type 1 diabetes
Nowak, Natalia; Skupien, Jan; Niewczas, Monika A.; Yamanouchi, Masayuki; Major, Melissa; Croall, Stephanie; Smiles, Adam; Warram, James H.; Bonventre, Joseph V.; Krolewski, Andrzej S. (2015)Progressively decreasing glomerular filtration rate (GFR), or renal decline, is seen in patients with type 1 diabetes (T1D) and normoalbuminuria or microalbuminuria. Here we examined the associations of kidney injury ... -
Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type-1 diabetes
Merchant, Michael L.; Niewczas, Monika; Ficociello, Linda H.; Lukenbill, Janice; Wilkey, Daniel W.; Li, Ming; Khundmiri, Syed J.; Warram, James H.; Krolewski, Andrzej S.; Klein, Jon B. (2013)The ability of microalbuminuria to predict early progressive renal function decline in type-1 diabetic patients has been questioned. To resolve this, we determined the plasma proteome differences between microalbuminuric ... -
Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes
Ficociello, Linda Hanna; Perkins, Bruce A.; Roshan, Bijan; Weinberg, Janice M.; Aschengrau, Ann; Warram, James H.; Krolewski, Andrzej Stefan (American Diabetes Association, 2009)OBJECTIVE - The purpose of this study was to examine prospectively whether renal hyperfiltration is associated with the development of microalbuminuria in patients with type 1 diabetes, after taking into account known risk ... -
Risk of ESRD and All Cause Mortality in Type 2 Diabetes According to Circulating Levels of FGF-23 and TNFR1
Lee, Jung Eun; Gohda, Tomohito; Walker, William H.; Skupien, Jan; Smiles, Adam M.; Holak, Rita R.; Jeong, Jackson; McDonnell, Kevin P.; Krolewski, Andrzej Stefan; Niewczas, Monika Anna (Public Library of Science, 2013)Introduction: Recent studies demonstrated that circulating fibroblast growth factor (FGF)-23 was associated with risk of end stage renal disease (ESRD) and mortality. This study aims to examine whether the predictive effect ... -
Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline
Wanic, Krzysztof; Krolewski, Bozena Krystyna; Ju, Wenjun; Placha, Grzegorz; Niewczas, Monika Anna; Walker, William; Warram, James H.; Kretzler, Matthias; Krolewski, Andrzej Stefan (Public Library of Science, 2013)Background: In patients with Type 1 Diabetes (T1D) who develop microalbuminuria, progressive decline in glomerular filtration rate (GFR) may be initiated by leakage into the urine of toxic proteins (txUPs). This study ... -
Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes
Pavkov, Meda E.; Weil, E. Jennifer; Fufaa, Gudeta D.; Nelson, Robert G.; Lemley, Kevin V.; Knowler, William C.; Niewczas, Monika A.; Krolewski, Andrzej S. (2015)Elevated serum tumor necrosis factor receptor 1 (TNFR1) and 2 (TNFR2) concentrations are strongly associated with increased risk of end-stage renal disease in type 2 diabetes. However, little is known about the early ... -
Uremic solutes and risk of end stage renal disease in type 2 diabetes
Niewczas, Monika A; Sirich, Tammy L; Mathew, Anna V; Skupien, Jan; Mohney, Robert P; Warram, James H; Smiles, Adam; Huang, Xiaoping; Walker, Walker; Byun, Jaeman; Karoly, Edward D; Kensicki, Elizabeth M; Berry, Gerard T; Bonventre, Joseph V; Pennathur, Subramaniam; Meyer, Timothy W; Krolewski, Andrzej S (2014)Here we studied plasma metabolomic profiles as determinants of progression to ESRD in patients with Type 2 diabetes (T2D). This nested case-control study evaluated 40 cases who progressed to ESRD during 8-12 years of ...