Browsing by Author "Kiel, Douglas"

Now showing items 1-20 of 31

    • The associations between QCT-based vertebral bone measurements and prevalent vertebral fractures depend on the spinal locations of both bone measurement and fracture 

      Anderson, Dennis Earl; Demissie, S.; Allaire, B. T.; Bruno, A. G.; Kopperdahl, D. L.; Keaveny, T. M.; Kiel, Douglas P.; Bouxsein, Mary Larsen (Springer Nature, 2013)
      Summary—We examined how spinal location affects the relationships between quantitative computed tomography (QCT)-based bone measurements and prevalent vertebral fractures. Upper spine (T4–T10) fractures appear to be more ...

    • A combined reference panel from the 1000 Genomes and UK10K projects improved rare variant imputation in European and Chinese samples 

      Chou, Wen-Chi; Zheng, Hou-Feng; Cheng, Chia-Ho; Han, Fang; Yan, Han; Wang, Li; Richards, J. Brent; Karasik, David; Kiel, Douglas P.; Hsu, Yi-Hsiang (Nature Publishing Group, 2016)
      Imputation using the 1000 Genomes haplotype reference panel has been widely adapted to estimate genotypes in genome wide association studies. To evaluate imputation quality with a relatively larger reference panel and a ...

    • Criteria for Clinically Relevant Weakness and Low Lean Mass and Their Longitudinal Association With Incident Mobility Impairment and Mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project 

      McLean, Robert R.; Shardell, Michelle D.; Alley, Dawn E.; Cawthon, Peggy M.; Fragala, Maren S.; Harris, Tamara B.; Kenny, Anne M.; Peters, Katherine W.; Ferrucci, Luigi; Guralnik, Jack M.; Kritchevsky, Stephen B.; Kiel, Douglas P.; Vassileva, Maria T.; Xue, Qian-Li; Perera, Subashan; Studenski, Stephanie A.; Dam, Thuy-Tien L. (Oxford University Press, 2014)
      Background. This analysis sought to determine the associations of the Foundation for the National Institutes of Health Sarcopenia Project criteria for weakness and low lean mass with likelihood for mobility impairment (gait ...

    • Cutpoints for Low Appendicular Lean Mass That Identify Older Adults With Clinically Significant Weakness 

      Cawthon, Peggy M.; Peters, Katherine W.; Shardell, Michelle D.; McLean, Robert R.; Dam, Thuy-Tien L.; Kenny, Anne M.; Fragala, Maren S.; Harris, Tamara B.; Kiel, Douglas P.; Guralnik, Jack M.; Ferrucci, Luigi; Kritchevsky, Stephen B.; Vassileva, Maria T.; Studenski, Stephanie A.; Alley, Dawn E. (Oxford University Press, 2014)
      Background. Low lean mass is potentially clinically important in older persons, but criteria have not been empirically validated. As part of the FNIH (Foundation for the National Institutes of Health) Sarcopenia Project, ...

    • DNA methylation-based measures of biological age: meta-analysis predicting time to death 

      Chen, Brian H.; Marioni, Riccardo E.; Colicino, Elena; Peters, Marjolein J.; Ward-Caviness, Cavin K.; Tsai, Pei-Chien; Roetker, Nicholas S.; Just, Allan C.; Demerath, Ellen W.; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Studenski, Stephanie; Vandiver, Amy R.; Moore, Ann Zenobia; Tanaka, Toshiko; Kiel, Douglas P.; Liang, Liming; Vokonas, Pantel; Schwartz, Joel; Lunetta, Kathryn L.; Murabito, Joanne M.; Bandinelli, Stefania; Hernandez, Dena G.; Melzer, David; Nalls, Michael; Pilling, Luke C.; Price, Timothy R.; Singleton, Andrew B.; Gieger, Christian; Holle, Rolf; Kretschmer, Anja; Kronenberg, Florian; Kunze, Sonja; Linseisen, Jakob; Meisinger, Christine; Rathmann, Wolfgang; Waldenberger, Melanie; Visscher, Peter M.; Shah, Sonia; Wray, Naomi R.; McRae, Allan F.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Absher, Devin; Assimes, Themistocles; Levine, Morgan E.; Lu, Ake T.; Tsao, Philip S.; Hou, Lifang; Manson, JoAnn E.; Carty, Cara L.; LaCroix, Andrea Z.; Reiner, Alexander P.; Spector, Tim D.; Feinberg, Andrew P.; Levy, Daniel; Baccarelli, Andrea; van Meurs, Joyce; Bell, Jordana T.; Peters, Annette; Deary, Ian J.; Pankow, James S.; Ferrucci, Luigi; Horvath, Steve (Impact Journals LLC, 2016)
      Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic age”, “DNAm age”, have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of ...

    • Dynamic Parameters of Balance Which Correlate to Elderly Persons with a History of Falls 

      Muir, Jesse W.; Kiel, Douglas P.; Hannan, Marian; Magaziner, Jay; Rubin, Clinton T. (Public Library of Science, 2013)
      Poor balance in older persons contributes to a rise in fall risk and serious injury, yet no consensus has developed on which measures of postural sway can identify those at greatest risk of falling. Postural sway was ...

    • Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms 

      Zhai, Guangju; Teumer, Alexander; Stolk, Lisette; Vandenput, Liesbeth; Coviello, Andrea D.; Koster, Annemarie; Bell, Jordana T.; Bhasin, Shalender; Eriksson, Joel; Eriksson, Anna; Ernst, Florian; Ferrucci, Luigi; Frayling, Timothy M.; Grundberg, Elin; Haring, Robin; Kroemer, Heyo K.; Liu, Yongmei; Lunetta, Kathryn L.; Maggio, Marcello; Lorentzon, Mattias; Mangino, Massimo; Melzer, David; Miljkovic, Iva; Nica, Alexandra; Penninx, Brenda W. J. H.; Vasan, Ramachandran S.; Rivadeneira, Fernando; Small, Kerrin S.; Soranzo, Nicole; Xi, Li; Zhuang, Wei Vivian; Harris, Tamara B.; Murabito, Joanne M.; Ohlsson, Claes; Murray, Anna; de Jong, Frank H.; Spector, Tim D.; Wallaschofski, Henri; Perry, John; Wilson, Scott G.; Glass, Daniel; Hofman, Albert; Kiel, Douglas P.; Hedman, Asa K.; Uitterlinden, Andre G.; Volzke, Henry (Public Library of Science, 2011)
      Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands, yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led ...

    • Evaluation of a new approach to compute intervertebral disc height measurements from lateral radiographic views of the spine 

      Allaire, Brett T.; DePaolis Kaluza, M. Clara; Bruno, Alexander G.; Samelson, Elizabeth J.; Kiel, Douglas P; Anderson, Dennis Earl; Bouxsein, Mary Larsen (Springer Nature, 2016)
      Purpose Current standard methods to quantify disc height, namely distortion compensated Roentgen analysis (DCRA), have been mostly utilized in the lumbar and cervical spine and have strict exclusion criteria. Specifically, ...

    • An Evidence-Based Comparison of Operational Criteria for the Presence of Sarcopenia 

      Dam, Thuy-Tien; Peters, Katherine W.; Fragala, Maren; Cawthon, Peggy M.; Harris, Tamara B.; McLean, Robert; Shardell, Michelle; Alley, Dawn E.; Kenny, Anne; Ferrucci, Luigi; Guralnik, Jack; Kiel, Douglas P.; Kritchevsky, Steve; Vassileva, Maria T.; Studenski, Stephanie (Oxford University Press, 2014)
      Background. Several consensus groups have previously published operational criteria for sarcopenia, incorporating lean mass with strength and/or physical performance. The purpose of this manuscript is to describe the ...

    • Fall Prevention with Supplemental and Active Forms of Vitamin D: A Meta-Analysis of Randomised Controlled Trials 

      Bischoff-Ferrari, H A; Dawson-Hughes, B; Staehelin, H B; Orav, J E; Stuck, A E; Theiler, R; Wong, J. B.; Egli, A; Kiel, Douglas P.; Henschkowski, J (BMJ Publishing Group Ltd., 2009)
      Objective: To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals. Data sources: We searched Medline, the Cochrane central register ...

    • The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates 

      Studenski, Stephanie A.; Peters, Katherine W.; Alley, Dawn E.; Cawthon, Peggy M.; McLean, Robert R.; Harris, Tamara B.; Ferrucci, Luigi; Guralnik, Jack M.; Fragala, Maren S.; Kenny, Anne M.; Kiel, Douglas P.; Kritchevsky, Stephen B.; Shardell, Michelle D.; Dam, Thuy-Tien L.; Vassileva, Maria T. (Oxford University Press, 2014)
      Background. Low muscle mass and weakness are common and potentially disabling in older adults, but in order to become recognized as a clinical condition, criteria for diagnosis should be based on clinically relevant ...

    • The Framingham Heart Study 100K SNP Genome-Wide Association Study Resource: Overview of 17 Phenotype Working Group Reports 

      Cupples, L Adrienne; Arruda, Heather T; Benjamin, Emelia J; D'Agostino, Ralph B; Demissie, Serkalem; DeStefano, Anita L; Dupuis, Josée; Govindaraju, Diddahally R; Heard-Costa, Nancy L; Hwang, Shih-Jen; Kathiresan, Sekar; Laramie, Jason M; Larson, Martin G; Liu, Chun-Yu; Lunetta, Kathryn L; Mailman, Matthew D; Manning, Alisa K; Murabito, Joanne M; O'Connor, George T; Pandey, Mona; Seshadri, Sudha; Vasan, Ramachandran S; Wilk, Jemma B; Wolf, Philip A; Yang, Qiong; Atwood, Larry D; Falls, Kathleen M; Fox, Caroline; Gottlieb, Daniel J; Guo, Chao-yu; Kiel, Douglas P.; Levy, Daniel; Meigs, James Benjamin; Newton-Cheh, Christopher Holmes; O'Donnell, Christopher Joseph; Wang, Zhen (BioMed Central, 2007)
      Background: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...

    • Fruit Intake and Abdominal Aortic Calcification in Elderly Women: A Prospective Cohort Study 

      Bondonno, Nicola P.; Lewis, Joshua R.; Prince, Richard L.; Lim, Wai H.; Wong, Germaine; Schousboe, John T.; Woodman, Richard J.; Kiel, Douglas P.; Bondonno, Catherine P.; Ward, Natalie C.; Croft, Kevin D.; Hodgson, Jonathan M. (MDPI, 2016)
      Cardiovascular disease (CVD) is the leading cause of death worldwide. There is a consistent inverse relationship between fruit intake with CVD events and mortality in cross-sectional and prospective observational studies, ...

    • Genetic Correlates of Longevity and Selected Age-related Phenotypes: A Genome-wide Association Study in the Framingham Study 

      Lunetta, Kathryn L; D'Agostino, Ralph B; Benjamin, Emelia J; Govindaraju, Raju; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M; Karasik, David; Guo, Chao-yu; Kiel, Douglas P. (BioMed Central, 2007)
      Background: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. Methods: We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) ...

    • Genetic diversity is a predictor of mortality in humans 

      Bihlmeyer, Nathan A; Brody, Jennifer A; Smith, Albert Vernon; Lunetta, Kathryn L; Nalls, Mike; Smith, Jennifer A; Tanaka, Toshiko; Davies, Gail; Yu, Lei; Mirza, Saira Saeed; Teumer, Alexander; Coresh, Josef; Pankow, James S; Franceschini, Nora; Scaria, Anish; Oshima, Junko; Psaty, Bruce M; Gudnason, Vilmundur; Eiriksdottir, Gudny; Harris, Tamara B; Li, Hanyue; Karasik, David; Kiel, Douglas P; Garcia, Melissa; Liu, Yongmei; Faul, Jessica D; Kardia, Sharon LR; Zhao, Wei; Ferrucci, Luigi; Allerhand, Michael; Liewald, David C; Redmond, Paul; Starr, John M; De Jager, Philip L; Evans, Denis A; Direk, Nese; Ikram, Mohammed Arfan; Uitterlinden, André; Homuth, Georg; Lorbeer, Roberto; Grabe, Hans J; Launer, Lenore; Murabito, Joanne M; Singleton, Andrew B; Weir, David R; Bandinelli, Stefania; Deary, Ian J; Bennett, David A; Tiemeier, Henning; Kocher, Thomas; Lumley, Thomas; Arking, Dan E (BioMed Central, 2014)
      Background: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both ...

    • A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation 

      Coviello, Andrea D.; Haring, Robin; Wellons, Melissa; Vaidya, Dhananjay; Lehtimäki, Terho; Keildson, Sarah; Lunetta, Kathryn L.; He, Chunyan; Fornage, Myriam; Lagou, Vasiliki; Mangino, Massimo; Onland-Moret, N. Charlotte; Eriksson, Joel; Garcia, Melissa; Liu, Yong Mei; Koster, Annemarie; Lohman, Kurt; Lyytikäinen, Leo-Pekka; Petersen, Ann-Kristin; Stolk, Lisette; Vandenput, Liesbeth; Wood, Andrew R.; Zhuang, Wei Vivian; Ruokonen, Aimo; Hartikainen, Anna-Liisa; Pouta, Anneli; Bandinelli, Stefania; Biffar, Reiner; Brabant, Georg; Chen, Yuhui; Cummings, Steven; Ferrucci, Luigi; Gunter, Marc J.; Martikainen, Hannu; Homuth, Georg; Illig, Thomas; Jansson, John-Olov; Karlsson, Magnus; Kettunen, Johannes; Liu, Jingmin; Ljunggren, Östen; Lorentzon, Mattias; Maggio, Marcello; Markus, Marcello R. P.; Mellström, Dan; Miljkovic, Iva; Mirel, Daniel; Morin Papunen, Laure; Peeters, Petra H. M.; Prokopenko, Inga; Raffel, Leslie; Reincke, Martin; Reiner, Alex P.; Rivadeneira, Fernando; Schwartz, Stephen M.; Siscovick, David; Soranzo, Nicole; Stöckl, Doris; Uitterlinden, André G.; van Gils, Carla H.; Vasan, Ramachandran S.; Wichmann, H.-Erich; Zhai, Guangju; Bhasin, Shalender; Bidlingmaier, Martin; Chanock, Stephen J.; Harris, Tamara B.; Kähönen, Mika; Liu, Simin; Ouyang, Pamela; Spector, Tim D.; van der Schouw, Yvonne T.; Viikari, Jorma; Wallaschofski, Henri; McCarthy, Mark I.; Frayling, Timothy M.; Murray, Anna; Franks, Steve; Järvelin, Marjo-Riitta; de Jong, Frank H.; Raitakari, Olli; Teumer, Alexander; Ohlsson, Claes; Murabito, Joanne M.; Perry, John R. B.; Chen, Brian; Prescott, Jennifer; Cox, David G.; Hankinson, Susan Elizabeth; Hofman, Albert; Johnson, Andrew D.; Karasik, David; Kiel, Douglas P.; Nelson, Sarah; Rexrode, Kathryn Marian; Tworoger, Shelley Slate; De Vivo, Immaculata; Hunter, David J.; Kraft, Peter (Public Library of Science, 2012)
      Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases ...

    • Genome-Wide Association with Bone Mass and Geometry in the Framingham Heart Study 

      Kiel, Douglas P.; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007)
      Background: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...

    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture 

      Estrada, Karol; Styrkarsdottir, Unnur; Evangelou, Evangelos; Hsu, Yi Hsiang; Duncan, Emma L; Ntzani, Evangelia E; Oei, Ling; Albagha, Omar M E; Amin, Najaf; Kemp, John P; Koller, Daniel L; Li, Guo; Liu, Ching-Ti; Minster, Ryan L; Moayyeri, Alireza; Vandenput, Liesbeth; Willner, Dana; Xiao, Su-Mei; Yerges-Armstrong, Laura M; Zheng, Hou-Feng; Alonso, Nerea; Eriksson, Joel; Kammerer, Candace M; Kaptoge, Stephen K; Leo, Paul J; Thorleifsson, Gudmar; Wilson, Scott G; Wilson, James F; Aalto, Ville; Alen, Markku; Aragaki, Aaron K; Aspelund, Thor; Center, Jacqueline R; Dailiana, Zoe; Duggan, David J; Garcia, Melissa; Garcia-Giralt, Natàlia; Giroux, Sylvie; Hallmans, Göran; Hocking, Lynne J; Husted, Lise Bjerre; Jameson, Karen A; Khusainova, Rita; Kim, Ghi Su; Kooperberg, Charles; Koromila, Theodora; Kruk, Marcin; Laaksonen, Marika; Lacroix, Andrea Z; Lee, Seung Hun; Leung, Ping C; Lewis, Joshua R; Masi, Laura; Mencej-Bedrac, Simona; Nguyen, Tuan V; Nogues, Xavier; Patel, Millan S; Prezelj, Janez; Rose, Lynda M; Scollen, Serena; Siggeirsdottir, Kristin; Smith, Albert V; Svensson, Olle; Trompet, Stella; Trummer, Olivia; van Schoor, Natasja M; Woo, Jean; Zhu, Kun; Balcells, Susana; Brandi, Maria Luisa; Buckley, Brendan M; Cheng, Sulin; Christiansen, Claus; Cooper, Cyrus; Dedoussis, George; Ford, Ian; Frost, Morten; Goltzman, David; González-Macías, Jesús; Kähönen, Mika; Karlsson, Magnus; Khusnutdinova, Elza; Koh, Jung-Min; Kollia, Panagoula; Langdahl, Bente Lomholt; Leslie, William D; Lips, Paul; Ljunggren, Östen; Lorenc, Roman S; Marc, Janja; Mellström, Dan; Obermayer-Pietsch, Barbara; Olmos, José M; Pettersson-Kymmer, Ulrika; Reid, David M; Riancho, José A; Ridker, Paul M; Rousseau, François; Slagboom, P Eline; Tang, Nelson LS; Urreizti, Roser; Van Hul, Wim; Viikari, Jorma; Zarrabeitia, María T; Aulchenko, Yurii S; Castano-Betancourt, Martha; Grundberg, Elin; Herrera, Lizbeth; Ingvarsson, Thorvaldur; Johannsdottir, Hrefna; Kwan, Tony; Li, Rui; Luben, Robert; Medina-Gómez, Carolina; Palsson, Stefan Th; Reppe, Sjur; Rotter, Jerome I; Sigurdsson, Gunnar; van Meurs, Joyce B J; Verlaan, Dominique; Williams, Frances MK; Wood, Andrew R; Zhou, Yanhua; Gautvik, Kaare M; Pastinen, Tomi; Raychaudhuri, Soumya; Cauley, Jane A; Chasman, Daniel Ian; Clark, Graeme R; Cummings, Steven R; Danoy, Patrick; Dennison, Elaine M; Eastell, Richard; Eisman, John A; Gudnason, Vilmundur; Hofman, Albert; Jackson, Rebecca D; Jones, Graeme; Jukema, J Wouter; Khaw, Kay-Tee; Lehtimäki, Terho; Liu, Yongmei; Lorentzon, Mattias; McCloskey, Eugene; Mitchell, Braxton D; Nandakumar, Kannabiran; Nicholson, Geoffrey C; Oostra, Ben A; Peacock, Munro; Pols, Huibert A P; Prince, Richard L; Raitakari, Olli; Reid, Ian R; Robbins, John; Sambrook, Philip N; Sham, Pak Chung; Shuldiner, Alan R; Tylavsky, Frances A; van Duijn, Cornelia M; Wareham, Nick J; Cupples, L Adrienne; Econs, Michael J; Evans, David M; Harris, Tamara B; Kung, Annie Wai Chee; Psaty, Bruce M; Reeve, Jonathan; Spector, Timothy D; Streeten, Elizabeth A; Zillikens, M Carola; Thorsteinsdottir, Unnur; Ohlsson, Claes; Karasik, David; Richards, J Brent; Brown, Matthew A; Stefansson, Kari; Uitterlinden, André G; Ralston, Stuart H; Ioannidis, John P A; Kiel, Douglas P.; Rivadeneira, Fernando (2012)
      Bone mineral density (BMD) is the most important predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 ...

    • Grip Strength Cutpoints for the Identification of Clinically Relevant Weakness 

      Alley, Dawn E.; Shardell, Michelle D.; Peters, Katherine W.; McLean, Robert R.; Dam, Thuy-Tien L.; Kenny, Anne M.; Fragala, Maren S.; Harris, Tamara B.; Kiel, Douglas P.; Guralnik, Jack M.; Ferrucci, Luigi; Kritchevsky, Stephen B.; Studenski, Stephanie A.; Vassileva, Maria T.; Cawthon, Peggy M. (Oxford University Press, 2014)
      Background. Weakness is common and contributes to disability, but no consensus exists regarding a strength cutpoint to identify persons at high risk. This analysis, conducted as part of the Foundation for the National ...

    • Heritability of Thoracic Spine Curvature and Genetic Correlations With Other Spine Traits: The Framingham Study 

      Yau, Michelle Szu-Huei; Demissie, Serkalem; Zhou, Yanhua; Anderson, Dennis Earl; Lorbergs, Amanda L; Kiel, Douglas P; Allaire, Brett T; Yang, Laiji; Cupples, L Adrienne; Travison, Thomas G; Bouxsein, Mary Larsen; Karasik, David; Samelson, Elizabeth J. (Wiley, 2016)
      Hyperkyphosis is a common spinal disorder in older adults, characterized by excessive forward curvature of the thoracic spine and adverse health outcomes. The etiology of hyperkyphosis has not been firmly established, but ...