Browsing by Author "Dominici, Francesca"
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Accounting for Uncertainty in Confounder and Effect Modifier Selection When Estimating Average Causal Effects in Generalized Linear Models
Wang, Chi; Dominici, Francesca; Parmigiani, Giovanni; Zigler, Corwin (Wiley, 2015-04-20)Confounder selection and adjustment are essential elements of assessing the causal effect of an exposure or treatment in observational studies. Building upon work by Wang et al. (2012, Biometrics 68, 661-671) and Lefebvre ... -
Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City
Johnson, Sarah; Bobb, Jennifer F.; Ito, Kazuhiko; Savitz, David A.; Elston, Beth; Shmool, Jessie L.C.; Dominici, Francesca; Ross, Zev; Clougherty, Jane E.; Matte, Thomas (National Institute of Environmental Health Sciences, 2016)Background: Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. Objective: We aimed to assess the relationship between air pollution and ... -
Association Between the Medicare Hospice Benefit and Health Care Utilization and Costs for Patients With Poor-Prognosis Cancer
Obermeyer, Ziad; Makar, Maggie; Abujaber, Samer; Dominici, Francesca; Block, Susan Dale; Cutler, David M. (American Medical Association (AMA), 2014)Importance More patients with cancer use hospice currently than ever before, but there are indications that care intensity outside of hospice is increasing, and length of hospice stay decreasing. Uncertainties regarding ... -
Associations between Long-Term Exposure to Chemical Constituents of Fine Particulate Matter (PM2.5) and Mortality in Medicare Enrollees in the Eastern United States
Chung, Yeonseung; Dominici, Francesca; Wang, Yun; Coull, Brent A.; Bell, Michelle L. (NLM-Export, 2015)Background: Several epidemiological studies have reported that long-term exposure to fine particulate matter (PM2.5) is associated with higher mortality. Evidence regarding contributions of PM2.5 constituents is inconclusive. ... -
Associations of PM2.5 Constituents and Sources with Hospital Admissions: Analysis of Four Counties in Connecticut and Massachusetts (USA) for Persons ≥ 65 Years of Age
Bell, Michelle L.; Ebisu, Keita; Leaderer, Brian P.; Gent, Janneane F.; Lee, Hyung Joo; Koutrakis, Petros; Wang, Yun; Dominici, Francesca; Peng, Roger D. (National Institute of Environmental Health Sciences, 2013)Background: Epidemiological studies have demonstrated associations between short-term exposure to PM2.5 and hospital admissions. The chemical composition of particles varies across locations and time periods. Identifying ... -
Bayesian Methods and Computation for Large Observational Datasets
Watts, Krista Leigh (2013-09-30)Much health related research depends heavily on the analysis of a rapidly expanding universe of observational data. A challenge in analysis of such data is the lack of sound statistical methods and tools that can address ... -
Completing the Results of the 2013 Boston Marathon
Hammerling, Dorit; Cefalu, Matthew; Cisewski, Jessi; Dominici, Francesca; Parmigiani, Giovanni; Paulson, Charles; Smith, Richard L. (Public Library of Science, 2014)The 2013 Boston marathon was disrupted by two bombs placed near the finish line. The bombs resulted in three deaths and several hundred injuries. Of lesser concern, in the immediate aftermath, was the fact that nearly 6,000 ... -
The effect of primary organic particles on emergency hospital admissions among the elderly in 3 US cities
Kioumourtzoglou, Marianthi-Anna; Zanobetti, Antonella; Schwartz, Joel D; Coull, Brent A; Dominici, Francesca; Suh, Helen H (BioMed Central, 2013)Background: Fine particle (PM2.5) pollution related to combustion sources has been linked to a variety of adverse health outcomes. Although poorly understood, it is possible that organic carbon (OC) species, particularly ... -
Estimating the Health Effects of Environmental Exposures: Statistical Methods for the Analysis of Spatio-temporal Data
Correia, Andrew William (2013-10-08)In the field of environmental epidemiology, there is a great deal of care required in constructing models that accurately estimate the effects of environmental exposures on human health. This is because the nature of the ... -
Heat stroke admissions during heat waves in 1,916 US counties for the period from 1999 to 2010 and their effect modifiers
Wang, Yan; Bobb, Jennifer F.; Papi, Bianca; Wang, Yun; Kosheleva, Anna; Di, Qian; Schwartz, Joel D.; Dominici, Francesca (BioMed Central, 2016)Background: Heat stroke is a serious heat-related illness, especially among older adults. However, little is known regarding the spatiotemporal variation of heat stroke admissions during heat waves and what factors modify ... -
Heat-Related Mortality and Adaptation to Heat in the United States
Bobb, Jennifer F.; Peng, Roger D.; Bell, Michelle L.; Dominici, Francesca (NLM-Export, 2014)Background: In a changing climate, increasing temperatures are anticipated to have profound health impacts. These impacts could be mitigated if individuals and communities adapt to changing exposures; however, little is ... -
The impact of source contribution uncertainty on the effects of source-specific PM2.5 on hospital admissions: A case study in Boston, MA
Kioumourtzoglou, Marianthi-Anna; Coull, Brent A; Dominici, Francesca; Koutrakis, Petros; Schwartz, Joel; Suh, Helen (Nature Publishing Group, 2014)Epidemiologic studies of particulate sources and adverse health do not account for the uncertainty in the source contribution estimates. Our goal was to assess the impact of uncertainty on the effect estimates of particulate ... -
Linking Student Performance in Massachusetts Elementary Schools with the “Greenness” of School Surroundings Using Remote Sensing
Wu, Chih-Da; McNeely, Eileen; Cedeño-Laurent, J. G.; Pan, Wen-Chi; Adamkiewicz, Gary; Dominici, Francesca; Lung, Shih-Chun Candice; Su, Huey-Jen; Spengler, John D. (Public Library of Science, 2014)Various studies have reported the physical and mental health benefits from exposure to “green” neighborhoods, such as proximity to neighborhoods with trees and vegetation. However, no studies have explicitly assessed the ... -
Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States
Kioumourtzoglou, Marianthi-Anna; Schwartz, Joel D.; Weisskopf, Marc G.; Melly, Steven J.; Wang, Yun; Dominici, Francesca; Zanobetti, Antonella (National Institute of Environmental Health Sciences, 2015)Background: Long-term exposure to fine particles (particulate matter ≤ 2.5 μm; PM2.5) has been consistently linked to heart and lung disease. Recently, there has been increased interest in examining the effects of air ... -
A national case-crossover analysis of the short-term effect of PM2.5 on hospitalizations and mortality in subjects with diabetes and neurological disorders
Zanobetti, Antonella; Dominici, Francesca; Wang, Yun; Schwartz, Joel D (BioMed Central, 2014)Background: Diabetes and neurological disorders are a growing burden among the elderly, and may also make them more susceptible to particulate air matter with aerodynamic diameter less than 2.5 μg (PM2.5). The same biological ... -
Residential exposure to aircraft noise and hospital admissions for cardiovascular diseases: multi-airport retrospective study
Correia, Andrew W; Peters, Junenette L; Levy, Jonathan I; Melly, Steven; Dominici, Francesca (BMJ Publishing Group Ltd., 2013)Objective: To investigate whether exposure to aircraft noise increases the risk of hospitalization for cardiovascular diseases in older people (≥65 years) residing near airports. Design: Multi-airport retrospective study ... -
Short-term Exposure to Particulate Matter Constituents and Mortality in a National Study of U.S. Urban Communities
Krall, Jenna R.; Anderson, G. Brooke; Dominici, Francesca; Bell, Michelle L.; Peng, Roger D. (National Institute of Environmental Health Sciences, 2013)Background: Although the association between PM2.5 mass and mortality has been extensively studied, few national-level analyses have estimated mortality effects of PM2.5 chemical constituents. Epidemiologic studies have ... -
Statistical Methods for Analyzing Complex Spatial and Missing Data
Antonelli, Joseph (2015-12-04)In chapter 1, we develop a novel two-dimensional wavelet decomposition to decompose spatial surfaces into different frequencies without imposing any restrictions on the form of the spatial surface. We illustrate the ... -
Statistical Methods for Effect Estimation in Biomedical Research: Robustness and Efficiency
Cefalu, Matthew Steven (2013-09-30)Practical application of statistics in biomedical research is predicated on the notion that one can readily return valid effect estimates of the health consequences of treatments (exposures) that are being studied. The ... -
Toward a Quantitative Estimate of Future Heat Wave Mortality under Global Climate Change
Peng, Roger D.; Bobb, Jennifer; Tebaldi, Claudia; McDaniel, Larry; Bell, Michelle D.; Dominici, Francesca (National Institute of Environmental Health Sciences, 2010)Background: Climate change is anticipated to affect human health by changing the distribution of known risk factors. Heat waves have had debilitating effects on human mortality, and global climate models predict an increase ...