Browsing Faculty of Arts and Sciences by Author "Kang, Kyungtae"
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Acetylation of Surface Lysine Groups of a Protein Alters the Organization and Composition of Its Crystal Contacts
Kang, Kyungtae; Choi, Jeong-Mo; Fox, Jerome M.; Snyder, Phillip W.; Moustakas, Demetri T.; Whitesides, George McClelland (American Chemical Society (ACS), 2016)This paper uses crystals of bovine carbonic anhydrase (CA) and its acetylated variant to examine (i) how a large negative formal charge can be accommodated in protein-protein interfaces, (ii) why lysine residues are often ... -
Anomalously Rapid Tunneling: Charge Transport across Self-Assembled Monolayers of Oligo(ethylene glycol)
Baghbanzadeh, Mostafa; Bowers, Carleen M.; Rappoport, Dmitrij; ?aba, Tomasz; Yuan, Li; Kang, Kyungtae; Liao, Kung-Ching; Gonidec, Mathieu; Rothemund, Philipp Josef Michael; Cyganik, Piotr; Aspuru-Guzik, Alan; Whitesides, George McClelland (American Chemical Society (ACS), 2017)This paper describes charge transport by tunneling across self-assembled monolayers (SAMs) of thiol-terminated derivatives of oligo(ethylene glycol) (HS(CH2CH2O)nCH3; HS(EG)nCH3); these SAMs are positioned between gold ... -
Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase
Fox, Jerome M.; Kang, Kyungtae; Sastry, Madhavi; Sherman, Woody; Sankaran, Banumathi; Zwart, Peter H.; Whitesides, George McClelland (Wiley-Blackwell, 2017)This study uses mutants of human carbonic anhydrase (HCAII) to examine how changes in the organization of water within a binding pocket can alter the thermodynamics of protein–ligand association. Results from calorimetric, ...