Browsing Faculty of Arts and Sciences by Author "Craigie, Robert"

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    • Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration 

      Li, Min; Jurado, Kellie A.; Lin, Shiqiang; Engelman, Alan; Craigie, Robert (Public Library of Science, 2014)
      The DNA cutting and joining reactions of HIV-1 integration are catalyzed by integrase (IN), a viral protein that functions as a tetramer bridging the two viral DNA ends (intasome). Two major obstacles for biochemical and ...