Browsing Faculty of Arts and Sciences by Keyword "Epigenetics"

Now showing items 21-23 of 23

    • The evolution of longevity in the context of epigenetic regulation and genetic sequence evolution 

      Richard, Daniel Joseph (2022-11-23)
      Modern-day humans enjoy an elongated lifespan relative to chimpanzees, even when accounting for environmental factors such as healthcare. This suggests that genetic changes to the biological processes underlying longevity ...

    • Uncovering the biology of chromatin regulators with drug resistance alleles 

      Freedy, Allyson Maria (2022-06-29)
      For millennia, small molecules have served as the backbone of humanity’s therapeutic arsenal. Often less well appreciated is the important role that small molecules have played in the discovery of new biological phenomena. ...

    • ZBED6 Modulates the Transcription of Myogenic Genes in Mouse Myoblast Cells 

      Jiang, Lin; Wallerman, Ola; Younis, Shady; Rubin, Carl-Johan; Gilbert, Elizabeth R.; Sundström, Elisabeth; Ghazal, Awaisa; Zhang, Xiaolan; Wang, Li; Mikkelsen, Tarjei S.; Andersson, Göran; Andersson, Leif (Public Library of Science, 2014)
      ZBED6 is a recently discovered transcription factor, unique to placental mammals, that has evolved from a domesticated DNA transposon. It acts as a repressor at the IGF2 locus. Here we show that ZBED6 acts as a transcriptional ...