Browsing Faculty of Arts and Sciences by Keyword "Crystallography"

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    • Crystal Structure of the FERM-SH2 Module of Human Jak2 

      McNally, Randall; Toms, Angela V.; Eck, Michael J. (Public Library of Science, 2016)
      Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the ...

    • Mechanistic Determinants of the Directionality and Energetics of Active Export by a Heterodimeric ABC Transporter 

      Grossmann, Nina; Vakkasoglu, Ahmet Selim; Hulpke, Sabine; Abele, Rupert; Gaudet, Rachelle; Tampé, Robert (Nature Publishing Group, 2014)
      The ATP-binding cassette (ABC) transporter associated with antigen processing (TAP) participates in immune surveillance by moving proteasomal products into the endoplasmic reticulum (ER) lumen for major histocompatibility ...