Browsing Faculty of Arts and Sciences by Keyword "motor neuron"

Now showing items 1-3 of 3

    • Exploring the Plasticity of Cellular Fate Using Defined-Factor Reprogramming 

      Son, Yesde (2012-11-02)
      Cellular fate, once established, is usually stable for the lifetime of the cell. However, the mechanisms that restrict the developmental potential of differentiated cells are in principle reversible, as demonstrated by the ...

    • The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD 

      Suzuki, Naoki; Maroof, Asif; Merkle, Florian T; Koszka, Kathryn; Intoh, Atsushi; Armstrong, Ian; Moccia, Rob; Davis-Dusenbery, Brandi N; Eggan, Kevin (2014)
      Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was ...

    • A screen for regulators of survival of motor neuron protein levels 

      Makhortova, Nina R; Hayhurst, Monica; Cerqueira, Antonio; Sinor-Anderson, Amy D; Zhao, Wen-Ning; Heiser, Patrick W; Arvanites, Arvanites; Davidow, Lance Steven; Waldon, Zachary O; Steen, Judith A; Lam, Kelvin; Ngo, Hien D; Rubin, Lee (Springer Nature, 2011)
      The motor neuron disease spinal muscular atrophy (SMA) results from mutations that lead to low levels of the ubiquitously expressed protein survival of motor neuron (SMN). An ever-increasing collection of data suggests ...