Browsing Faculty of Arts and Sciences by Keyword "DNA damage"
Now showing items 1-6 of 6
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Constant rate of p53 tetramerization in response to DNA damage controls the p53 response
(BlackWell Publishing Ltd, 2014)The dynamics of the tumor suppressor protein p53 have been previously investigated in single cells using fluorescently tagged p53. Such approach reports on the total abundance of p53 but does not provide a measure for ... -
Dynamics of p53 tetramers in live single cells
(2014-06-06)Protein homo-oligomerization is the process through which identical peptides bind together to form higher order complexes. Self-interactions in many cases are constitutive and stable, used as building blocks for biological ... -
Enhanced Genomic Stability and its Effects on Aging and the Epigenome
(2022-01-18)The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ... -
Polo-Like Kinase 1 Depletion Induces DNA Damage in Early S Prior to Caspase Activation
(American Society for Microbiology, 2009)Polo-like kinase 1 (Plk1) plays several roles in mitosis, and it has been suggested to have a role in tumorigenesis. We have previously reported that Plk1 depletion results in cell death in cancer cells, whereas normal ... -
Tracking Cell Fate with Synthetic Memory and Pulse Detecting Transcriptional Circuits
(2014-06-06)Synthetic biology aims to engineer biological systems to meet new challenges and teach us more about natural biological systems. These pursuits range from the building of relatively simple transcriptional circuits, to ... -
Understanding the requirement of PRMT5 splicing regulation in Merkel cell carcinoma.
(2023-06-01)Merkel cell carcinoma (MCC) is an aggressive, highly metastatic neuroendocrine skin cancer. Immune checkpoint therapies have greatly improved the overall survival rate of patients with late-stage disease, however patients ...