Browsing Faculty of Arts and Sciences by Keyword "Epigenetics"
Now showing items 1-20 of 23
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Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood
(BioMed Central, 2016)Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic ... -
Chromatin Modification by PSC Occurs at One PSC per Nucleosome and Does Not Require the Acidic Patch of Histone H2A
(Public Library of Science, 2012)Chromatin architecture is regulated through both enzymatic and non-enzymatic activities. For example, the Polycomb Group (PcG) proteins maintain developmental gene silencing using an array of chromatin-based mechanisms. ... -
Dissecting the embryonic and extraembryonic requirements for DNA methylation in mice
(2021-09-10)DNA methylation is a remarkably dynamic repressive DNA modification that can be stably propagated over successive cell divisions and forms an essential layer of the epigenetic landscape that defines each cell. In the early ... -
Dynamics and spatiotemporal organization of mammalian SWI/SNF chromatin remodeling complexes in transcriptional regulation
(2023-06-01)ATP-dependent chromatin remodeling complexes play critical roles in the maintenance of tissue- and state-specific chromatin structure; however, the spatial organization and dynamics of these remodelers, as well as their ... -
Enhanced Genomic Stability and its Effects on Aging and the Epigenome
(2022-01-18)The epigenomes of evolutionarily distant species undergo similar alterations during aging, but the upstream causes of these changes are unclear. DNA damage is one potential cause, as epigenetic changes arising from DNA ... -
Epigenetic based therapeutic strategies to drive differentiation and death in KRAS mutant colorectal cancers
(2023-06-01)Colorectal cancer (CRC) is one of the leading causes cancer deaths worldwide, and advanced metastatic disease is still incurable. Mutations in the KRAS oncogene occur in 30-50% of all CRC and render the malignancy resistant ... -
Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells
(BioMed Central, 2015)Background: Casein-free, gluten-free diets have been reported to mitigate some of the inflammatory gastrointestinal and behavioral traits associated with autism, but the mechanism for this palliative effect has not been ... -
Fluctuation Timescales in Bacterial Gene Expression
(2014-02-25)The stochastic nature of intracellular chemistry guarantees that even genetically identical cells sharing an environment will differ in composition. The question of whether this chemical diversity translates into significant ... -
Identifying novel genetic drivers of melanoma initiation, metastasis, and drug resistance using zebrafish
(2021-07-12)Sun-exposed cutaneous melanoma has the highest genomic mutational burden of all tumor types. Progression towards metastasis is responsible for most melanoma-related mortality, yet no recurrent mutations specifically driving ... -
Illuminating the nonenzymatic functions of LSD1 complexes in leukemia using drug resistance alleles
(2023-01-10)The identification of drug resistance conferring mutations not only confirms on-target small molecule mechanism but can also serve as a useful discovery tool to uncover novel aspects of target biology. However, the ... -
In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
(Public Library of Science, 2012)The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood. Here, we describe a comprehensive analysis of DNA methylation ... -
Investigating the cis-regulatory mechanisms underlying neuronal imprinted expression
(2024-01-22)Differences in chromatin state inherited from the parental gametes influence the regulation of maternal and paternal alleles in offspring. This phenomenon, known as genomic imprinting, results in genes preferentially ... -
Locus-Dependent Epigenetic Inheritance of Polycomb-Mediated Gene Silencing
(2022-05-10)During development, it is crucial that gene expression patterns, which define cell phenotypes and “epigenetic states”, are stably inherited. The maintenance of epigenetic states involves changes in repressive histone ... -
Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study
(2016)Background: Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based ... -
miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga
(Public Library of Science, 2016)Cellular and systemic responses to low oxygen levels are principally mediated by Hypoxia Inducible Factors (HIFs), a family of evolutionary conserved heterodimeric transcription factors, whose alpha- and beta-subunits ... -
poly(UG)-tailed RNAs and Transgenerational Epigenetic Inheritance in C. elegans
(2021-03-05)Small noncoding RNAs (small RNAs) such as Piwi-interacting RNAs (piRNAs), microRNA (miRNAs), and short-interfering RNAs (siRNAs) are important regulators of gene expression. Small RNAs are bound by Argonaute proteins and, ... -
The Role of Muscle microRNAs in Repairing the Neuromuscular Junction
(Public Library of Science, 2014)microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote ... -
A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests
(Public Library of Science, 2013)Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary – albeit often ineffective – treatment ... -
Systematic Interrogation of CBP/p300 Dependency in Cancer
(2023-12-12)CBP and p300 are closely related paralogs that function as versatile transcriptional co-activator proteins. These paralogs function as histone acetyltransferases (HATs) and mediate canonical signaling programs by acetylating ... -
Targeting the Epigenetic Lesion in MLL-Rearranged Leukemia
(2013-03-18)It has become increasingly apparent that the misregulation of histone modification actively contributes to cancer. The histone H3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias ...