Browsing FAS Scholarly Articles by Keyword "Immunology"
Now showing items 21-30 of 30
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Myeloid Clusters Are Associated with a Pro-Metastatic Environment and Poor Prognosis in Smoking-Related Early Stage Non-Small Cell Lung Cancer
(Public Library of Science, 2013)Background: This study aimed to understand the role of myeloid cell clusters in uninvolved regional lymph nodes from early stage non-small cell lung cancer patients. Methods: Uninvolved regional lymph node sections from ... -
Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection
(Public Library of Science, 2016)Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive ... -
Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences
(Public Library of Science, 2016)Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to prevent HIV-1. A major unmet need for the field has been the lack ... -
Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
(Public Library of Science, 2016)Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are ... -
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells
(Public Library of Science, 2014)Genome-wide association studies (GWAS) and subsequent dense-genotyping of associated loci identified over a hundred single-nucleotide polymorphism (SNP) variants associated with the risk of rheumatoid arthritis (RA), type ... -
Retrotransposon Gag-Like 1 (RTL1) and the Molecular Evolution of Self-Targeting Imprinted microRNAs
(Springer Science and Business Media LLC, 2019-10-22)Background: Transcription of the antisense strand of RTL1 produces a sense mRNA that is targeted for degradation by antisense microRNAs transcribed from the sense strand. Translation of the mRNA produces a retrotransposonderived ... -
Single-molecule imaging reveals that Z-ring condensation is essential for cell division in Bacillus subtilis
(Springer Science and Business Media LLC, 2021-03-18)Although many components of the cell division machinery in bacteria have been identified, the mechanisms by which they work together to divide the cell remain poorly understood. Key among these components is the tubulin ... -
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection
(Public Library of Science, 2016)While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ... -
Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label
(Public Library of Science, 2013)We describe a novel photoconversion technique to track individual cells in vivo using a commercial lipophilic membrane dye, DiR. We show that DiR exhibits a permanent fluorescence emission shift (photoconversion) after ... -
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection
(Public Library of Science, 2016)The contribution of pre-mRNA processing mechanisms to the regulation of immune responses remains poorly studied despite emerging examples of their role as regulators of immune defenses. We sought to investigate the role ...