Browsing FAS Scholarly Articles by Title
Now showing items 4113-4132 of 18296
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DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease
(Oxford University Press, 2013)The central nervous system has a pattern of gene expression that is closely regulated with respect to functional and anatomical regions. DNA methylation is a major regulator of transcriptional activity, and aberrations in ... -
DNA methylation signatures link prenatal famine exposure to growth and metabolism
(Nature Pub. Group, 2014)Periconceptional diet may persistently influence DNA methylation levels with phenotypic consequences. However, a comprehensive assessment of the characteristics of prenatal malnutrition-associated differentially methylated ... -
DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish
(BioMed Central, 2015)Background: DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic development ... -
DNA molecules and configurations in a solid-state nanopore microscope
(Nature Publishing Group, 2003)A nanometre scale pore in a solid state membrane provides a new way to electronically probe the structure of single linear polymers, including those of biological interest in their native environments. Previous work with ... -
DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader
(2015)The DNA replication machinery is an important target for antibiotic development for increasingly drug resistant bacteria including Mycobacterium tuberculosis1. While blocking DNA replication leads to cell death, disrupting ... -
DNA replication timing and higher-order nuclear organization determine single nucleotide substitution patterns in cancer genomes
(2013)Single nucleotide substitutions (SNS) are a defining characteristic of cancer genomes. Many SNS in cancer genomes arise due to errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA ... -
DNA Unzipping Phase Diagram Calculated Via Replica Theory
(American Physical Society, 2009)We show how single-molecule unzipping experiments can provide strong evidence that the zero-force melting transition of long molecules of natural dsDNA should be classified as a phase transition of the higher-order type ... -
A DNA-based molecular probe for optically reporting cellular traction forces
(2014)We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs ... -
DNA-Binding Specificity Changes in the Evolution of Forkhead Transcription Factors
(Proceedings of the National Academy of Sciences, 2013)The evolution of transcriptional regulatory networks entails the expansion and diversification of transcription factor (TF) families. The forkhead family of TFs, defined by a highly conserved winged helix DNA-binding domain ... -
DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes
(American Chemical Society (ACS), 2008)The DNA-templated polymerization of synthetic building blocks provides a potential route to the laboratory evolution of sequence-defined polymers with structures and properties not necessarily limited to those of natural ... -
Dnmt1 Has De Novo Activity Targeted to Transposable Elements
(Springer Science and Business Media LLC, 2021-06-17)<jats:title>Abstract</jats:title><jats:p>DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities ... -
DNMT1-interacting RNAs block gene specific DNA methylation
(2013)Summary DNA methylation was described almost a century ago. However, the rules governing its establishment and maintenance remain elusive. Here, we present data demonstrating that active transcription regulates levels of ... -
Do Corrupt Governments Receive Less Foreign Aid?
(American Economic Association, 2002)Critics of foreign aid programs argue that these funds often support corrupt governments and inefficient bureaucracies. Supporters argue that foreign aid can be used to reward good governments. This paper documents that ... -
Do DSM-5 Eating Disorder Criteria Overpathologize Normative Eating Patterns among Individuals with Obesity?
(Hindawi Publishing Corporation, 2014)Background. DSM-5 revisions have been criticized in the popular press for overpathologizing normative eating patterns—particularly among individuals with obesity. To evaluate the evidence for this and other DSM-5 critiques, ... -
Do Institutions Cause Growth?
(Springer Science + Business Media, 2004)We revisit the debate over whether political institutions cause economic growth, or whether, alternatively, growth and human capital accumulation lead to institutional improvement. We find that most indicators of institutional ... -
Do Labor Unions Have a Future in the United States?
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Do Managerial Objectives Drive Bad Acquisitions?
(Wiley, 1990)This paper documents for a sample of 327 US acquisitions between 1975 and 1987 three forces that systematically reduce the announcement day return of bidding firms. The returns to bidding shareholders are lower when their ... -
Do Password Managers Improve Password Hygiene?
(2022-12-24)Password managers purport to increase users' security by improving password hygiene: generating unique random passwords when users create new accounts, replacing users' weak and reused passwords, and determining which sites ... -
Do the Electrons and Ions in X‐Ray Clusters Share the Same Temperature?
(American Astronomical Society, 1997)The virialization shock around an X-ray cluster primarily heats the ions, since they carry most of the kinetic energy of the infalling gas. Subsequently, the ions share their thermal energy with the electrons through Coulomb ... -
Do Transmission Mechanisms or Social Systems Drive Cultural Dynamics in Socially Structured Populations?
(Elsevier, 2009)Cultural traits spread via multiple mechanisms among individuals within social groups, including via transmission biases that occur when subordinates copy from dominants (prestige transmission), or via common cultural trait ...