Browsing FAS Scholarly Articles by Keyword "chemical biology"
Now showing items 1-9 of 9
-
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
(Nature Publishing Group, 2014)Despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of IDE (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between ... -
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine
(eLife Sciences Publications, Ltd, 2016)Phenotypic screens allow the identification of small molecules with promising anticancer activity, but the difficulty in characterizing the mechanism of action of these compounds in human cells often undermines their value ... -
Bioinspiration: something for everyone
(The Royal Society, 2015)‘Bioinspiration’—using phenomena in biology to stimulate research in non-biological science and technology—is a strategy that suggests new areas for research. Beyond its potential to nucleate new ideas, bioinspiration has ... -
Cell Encapsulation in Sub-mm Sized Gel Modules Using Replica Molding
(Public Library of Science, 2008)For many types of cells, behavior in two-dimensional (2D) culture differs from that in three-dimensional (3D) culture. Among biologists, 2D culture on treated plastic surfaces is currently the most popular method for cell ... -
Chemistry and the Worm: Caenorhabditis elegans as a Platform for Integrating Chemical and Biological Research
(Wiley-Blackwell, 2011)This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a model organism for chemists interested in studying living systems. C. elegans, a 1 mm long roundworm, is a popular model organism in ... -
Empirical Bayes Analysis of Quantitative Proteomics Experiments
(Public Library of Science, 2009)Background: Advances in mass spectrometry-based proteomics have enabled the incorporation of proteomic data into systems approaches to biology. However, development of analytical methods has lagged behind. Here we describe ... -
Imaging Poliovirus Entry in Live Cells
(Public Library of Science, 2007)Viruses initiate infection by transferring their genetic material across a cellular membrane and into the appropriate compartment of the cell. The mechanisms by which animal viruses, especially nonenveloped viruses, deliver ... -
A population-based experimental model for protein evolution: Effects of mutation rate and selection stringency on evolutionary outcomes
(American Chemical Society (ACS), 2013)Protein evolution is a critical component of organismal evolution and a valuable method for the generation of useful molecules in the laboratory. Few studies, however, have experimentally characterized how fundamental ... -
The use of small molecules in somatic-cell reprogramming
(Elsevier BV, 2014)Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by ...