Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model
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https://doi.org/10.1128/IAI.73.10.7043-7046.2005Metadata
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Trzcinski, K., C. Thompson, R. Malley, and M. Lipsitch. 2005. “Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection Against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model.” Infection and Immunity 73 (10) (September 21): 7043–7046. doi:10.1128/iai.73.10.7043-7046.2005.Abstract
In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1230924/Terms of Use
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