Eosinophils and disease pathogenesis
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https://doi.org/10.1053/j.seminhematol.2012.01.005Metadata
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Akuthota, Praveen, and Peter F. Weller. 2012. Eosinophils and disease pathogenesis. Seminars in Hematology 49, no. 2: 113–119. doi:10.1053/j.seminhematol.2012.01.005.Abstract
Eosinophils are granulocytic innate immune cells whose presence is conspicuous in a variety of disease states, including eosinophilic hyperproliferative and infiltrative processes, as well as conditions associated with maladaptive Th2 inflammation. This review discusses the role of eosinophils in disease pathogenesis, including a consideration of relevant eosinophil biology. Eosinophilic disease patterns of tissue infiltration are also detailed, as are candidate mechanisms by which eosinophils cause fibrosis and hypercoagulability and the importance of eosinophils in allergic inflammation. Eosinophils are unique cells in their spectrum of associated disease, with the promise of future discoveries in delineating the manner in which they contribute to disease pathogenesis.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571705/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:27377616
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