Genome-wide patterns of selection in 230 ancient Eurasians
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Author
Rohland, Nadin
Patterson, Nick
Roodenberg, Songül Alpaslan
Fernandes, Daniel
Novak, Mario
Sirak, Kendra
Gamba, Cristina
Jones, Eppie R.
Llamas, Bastien
Dryomov, Stanislav
Pickrel, Joseph
Arsuaga, Juan Luís
de Castro, José María Bermúdez
Carbonell, Eudald
Gerritsen, Fokke
Khokhlov, Aleksandr
Kuznetsov, Pavel
Lozano, Marina
Meller, Harald
Mochalov, Oleg
Moiseyev, Vayacheslav
Rojo Guerra, Manuel A.
Roodenberg, Jacob
Vergès, Josep Maria
Krause, Johannes
Cooper, Alan
Alt, Kurt W.
Brown, Dorcas
Anthony, David
Lalueza-Fox, Carles
Haak, Wolfgang
Pinhasi, Ron
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nature16152Metadata
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Mathieson, I., I. Lazaridis, N. Rohland, S. Mallick, N. Patterson, S. A. Roodenberg, E. Harney, et al. 2016. “Genome-wide patterns of selection in 230 ancient Eurasians.” Nature 528 (7583): 499-503. doi:10.1038/nature16152. http://dx.doi.org/10.1038/nature16152.Abstract
Ancient DNA makes it possible to directly witness natural selection by analyzing samples from populations before, during and after adaptation events. Here we report the first scan for selection using ancient DNA, capitalizing on the largest genome-wide dataset yet assembled: 230 West Eurasians dating to between 6500 and 1000 BCE, including 163 with newly reported data. The new samples include the first genome-wide data from the Anatolian Neolithic culture whose genetic material we extracted from the DNA-rich petrous bone and who we show were members of the population that was the source of Europe’s first farmers. We also report a complete transect of the steppe region in Samara between 5500 and 1200 BCE that allows us to recognize admixture from at least two external sources into steppe populations during this period. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918750/pdf/Terms of Use
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