dc.contributor.author | Culhane, Aedin | |
dc.contributor.author | Quackenbush, John | |
dc.date.accessioned | 2016-10-13T19:27:20Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Culhane, A. C., and J. Quackenbush. 2009. “Confounding Effects in ‘A Six-Gene Signature Predicting Breast Cancer Lung Metastasis.’” Cancer Research 69 (18) (September 1): 7480–7485. doi:10.1158/0008-5472.can-08-3350. | en_US |
dc.identifier.issn | 0008-5472 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29004171 | |
dc.description.abstract | The majority of breast cancer deaths result from metastases rather than from direct effects of the primary tumor itself. Recently, Landemaine and colleagues described a six-gene signature purported to predict lung metastasis risk. They analyzed gene expression in 23 metastases from breast cancer patients (5 lung, 18 non-lung) identifying a 21-gene signature. Expression of 16 of these was analyzed in primary breast tumors from 72 patients with known outcome, and six were selected that were predictive of lung metastases: DSC2, TFCP2L1, UGT8, ITGB8, ANP32E, and FERMT1. Despite the value of such a signature, our analysis indicates that this analysis ignored potentially important confounding factors and that their signature is instead a surrogate for molecular subtype. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Association for Cancer Research (AACR) | en_US |
dc.relation.isversionof | doi:10.1158/0008-5472.CAN-08-3350 | en_US |
dc.relation.hasversion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128918/ | en_US |
dash.license | LAA | |
dc.title | Confounding Effects in "A Six-Gene Signature Predicting Breast Cancer Lung Metastasis" | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Cancer Research | en_US |
dash.depositing.author | Culhane, Aedin | |
dc.date.available | 2016-10-13T19:27:20Z | |
dc.identifier.doi | 10.1158/0008-5472.CAN-08-3350 | * |
dash.contributor.affiliated | Culhane, Aedin | |
dash.contributor.affiliated | Quackenbush, John | |
dc.identifier.orcid | 0000-0002-2702-5879 | |