Browsing SPH Scholarly Articles by Author "Kirchner, Rory"
Now showing items 1-3 of 3
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edgeRun: an R package for sensitive, functionally relevant differential expression discovery using an unconditional exact test
Dimont, Emmanuel; Shi, Jiantao; Kirchner, Rory; Hide, Winston (Oxford University Press, 2015)Summary: Next-generation sequencing platforms for measuring digital expression such as RNA-Seq are displacing traditional microarray-based methods in biological experiments. The detection of differentially expressed genes ... -
GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations
Paila, Umadevi; Chapman, Brad A.; Kirchner, Rory; Quinlan, Aaron R. (Public Library of Science, 2013)Modern DNA sequencing technologies enable geneticists to rapidly identify genetic variation among many human genomes. However, isolating the minority of variants underlying disease remains an important, yet formidable ... -
Sequencing of Captive Target Transcripts Identifies the Network of Regulated Genes and Functions of Primate-Specific miR-522
Tan, Shen Mynn; Kirchner, Rory D; Jin, Jingmin; Hofmann, Oliver Marc; McReynolds, Larry; Hide, Winston; Lieberman, Judy (Elsevier BV, 2014)Identifying microRNA (miRNA)-regulated genes is key to understanding miRNA function. However, many miRNA recognition elements (MREs) do not follow canonical “seed” base-pairing rules, making identification of bona fide ...