Browsing SPH Scholarly Articles by Title
Now showing items 725-744 of 6362
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BatchQC: interactive software for evaluating sample and batch effects in genomic data
(Oxford University Press, 2016)Sequencing and microarray samples often are collected or processed in multiple batches or at different times. This often produces technical biases that can lead to incorrect results in the downstream analysis. There are ... -
A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway
(Public Library of Science, 2012)Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ... -
Bayes-LQAS: Classifying the Prevalence of Global Acute Malnutrition
(BioMed Central, 2010)Lot Quality Assurance Sampling (LQAS) applications in health have generally relied on frequentist interpretations for statistical validity. Yet health professionals often seek statements about the probability distribution ... -
Bayesian Analysis of Haplotypes for Linkage Disequilibrium Mapping
(Cold Spring Harbor Laboratory Press, 2001)Haplotype analysis of disease chromosomes can help identify probable historical recombination events and localize disease mutations. Most available analyses use only marginal and pairwise allele frequency information. We ... -
Bayesian and Maximum Likelihood Phylogenetic Analyses of Protein Sequence Data Under Relative Branch-Length Differences and Model Violation
(BioMed Central, 2005)Background: Bayesian phylogenetic inference holds promise as an alternative to maximum likelihood, particularly for large molecular-sequence data sets. We have investigated the performance of Bayesian inference with empirical ... -
A Bayesian Approach for Fast and Accurate Gene Tree Reconstruction
(Oxford University Press, 2011)Recent sequencing and computing advances have enabled phylogenetic analyses to expand to both entire genomes and large clades, thus requiring more efficient and accurate methods designed specifically for the phylogenomic ... -
Bayesian Estimation of Mixture Models with Prespecified Elements to Compare Drug Resistance in Treatment-Naïve and Experienced Tuberculosis Cases
(Public Library of Science, 2013)We propose a Bayesian approach for estimating branching tree mixture models to compare drug-resistance pathways (i.e. patterns of sequential acquisition of resistance to individual antibiotics) that are observed among ... -
A Bayesian Framework for the Classification of Microbial Gene Activity States
(Frontiers Media S.A., 2016)Numerous methods for classifying gene activity states based on gene expression data have been proposed for use in downstream applications, such as incorporating transcriptomics data into metabolic models in order to improve ... -
Bayesian nonparametric cross-study validation of prediction methods
(Institute of Mathematical Statistics, 2015)We consider comparisons of statistical learning algorithms using multiple data sets, via leave-one-in cross-study validation: each of the algorithms is trained on one data set; the resulting model is then validated on each ... -
Bedside Availability of Prepared Oxytocin and Rapid Administration After Delivery to Prevent Postpartum Hemorrhage: An Observational Study in Karnataka, India
(Global Health: Science and Practice, 2015)Postpartum hemorrhage is a leading cause of maternal death worldwide. Rapid provision of uterotonics after childbirth is recommended to reduce the incidence and severity of postpartum hemorrhage. Data obtained through ... -
Behavioral Counseling Training for Primary Care Providers: Immersive Virtual Simulation as a Training Tool
(Frontiers Media SA, 2019-05-09)Behavioral counseling represents an efficacious approach for improving health behaviors on a population level, and the primary care setting is an appropriate context in which to implement this approach. However, evidence ... -
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV
(BioMed Central, 2014)Mucolipidosis IV (MLIV) is caused by mutations in the gene MCOLN1. Patients with MLIV have severe neurologic deficits and very little is known about the brain pathology in this lysosomal disease. Using an accurate mouse ... -
Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances
(Elsevier BV, 2016)Background: Perfluorinated alkyl substances (PFAS) are suspected endocrine disruptors that are highly persistent and neurotoxic in animals. Human epidemiological studies of exposure-related deviations of children’s behaviors ... -
Behavioral Interventions to Prevent HIV Transmission and Acquisition for Transgender Women: A Critical Review
(JAIDS Journal of Acquired Immune Deficiency Syndromes, 2016)Abstract: Worldwide, transgender women are at disproportionately higher risk of HIV infection, with the primary mode of infection being condomless anal intercourse. Although very few HIV prevention interventions have been ... -
Benchmark Dose Calculation from Epidemiological Data
(Wiley, 2001-09)A threshold for dose-dependent toxicity is crucial for standards setting but may not be possible to specify from empirical studies. Crump (1984) instead proposed calculating the lower statistical confidence bound of the ... -
Benchmark Dose Calculations for Methylmercury-Associated Delays on Evoked Potential Latencies in Two Cohorts of Children
(Wiley-Blackwell, 2002)Delays in evoked potential latencies were observed at increased exposures to methylmercury from seafood in two cohorts of children. Because this outcome parameter appeared to be virtually independent of confounders, including ... -
Benchmark dose calculations of methylmercury-associated neurobehavioural deficits
(Elsevier BV, 2000)Prenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury ... -
A benchmark for RNA-seq quantification pipelines
(BioMed Central, 2016)Obtaining RNA-seq measurements involves a complex data analytical process with a large number of competing algorithms as options. There is much debate about which of these methods provides the best approach. Unfortunately, ... -
Benchmarks for Operative Outcomes of Robotic and Open Radical Prostatectomy: Results from the Health Professionals Follow-up Study
(Elsevier, 2015)Background: Robot-assisted laparoscopic radical prostatectomy (RALP) has become increasingly common; however, there have been no nationwide, population-based, non-claims-based studies to evaluate differences in outcomes ... -
Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV-tuberculosis coinfected populations
(Proceedings of the National Academy of Sciences, 2006)In sub-Saharan Africa, where the emergence of HIV has caused dramatic increases in tuberculosis (TB) case notifications, new strategies for TB control are necessary. Isoniazid preventive therapy (IPT) for HIV-TB coinfected ...