Now showing items 1-10 of 10

    • Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure 

      Smith, J. Gustav; Felix, Janine F.; Morrison, Alanna C.; Kalogeropoulos, Andreas; Trompet, Stella; Wilk, Jemma B.; Gidlöf, Olof; Wang, Xinchen; Morley, Michael; Mendelson, Michael; Joehanes, Roby; Ligthart, Symen; Shan, Xiaoyin; Bis, Joshua C.; Wang, Ying A.; Sjögren, Marketa; Ngwa, Julius; Brandimarto, Jeffrey; Stott, David J.; Aguilar, David; Rice, Kenneth M.; Sesso, Howard D.; Demissie, Serkalem; Buckley, Brendan M.; Taylor, Kent D.; Ford, Ian; Yao, Chen; Liu, Chunyu; Sotoodehnia, Nona; van der Harst, Pim; Stricker, Bruno H. Ch.; Kritchevsky, Stephen B.; Liu, Yongmei; Gaziano, J. Michael; Hofman, Albert; Moravec, Christine S.; Uitterlinden, André G.; Kellis, Manolis; van Meurs, Joyce B.; Margulies, Kenneth B.; Dehghan, Abbas; Levy, Daniel; Olde, Björn; Psaty, Bruce M.; Cupples, L. Adrienne; Jukema, J. Wouter; Djousse, Luc; Franco, Oscar H.; Boerwinkle, Eric; Boyer, Laurie A.; Newton-Cheh, Christopher; Butler, Javed; Vasan, Ramachandran S.; Cappola, Thomas P.; Smith, Nicholas L. (Public Library of Science, 2016)
      Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular ...
    • Disrupting Mosquito Reproduction and Parasite Development for Malaria Control 

      Childs, Lauren M.; Cai, Francisco Y.; Kakani, Evdoxia G.; Mitchell, Sara N.; Paton, Doug; Gabrieli, Paolo; Buckee, Caroline O.; Catteruccia, Flaminia (Public Library of Science, 2016)
      The control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in ...
    • Geographical Inequalities and Social and Environmental Risk Factors for Under-Five Mortality in Ghana in 2000 and 2010: Bayesian Spatial Analysis of Census Data 

      Arku, Raphael E.; Bennett, James E.; Castro, Marcia C.; Agyeman-Duah, Kofi; Mintah, Samilia E.; Ware, James H.; Nyarko, Philomena; Spengler, John D.; Agyei-Mensah, Samuel; Ezzati, Majid (Public Library of Science, 2016)
      Background: Under-five mortality is declining in Ghana and many other countries. Very few studies have measured under-five mortality—and its social and environmental risk factors—at fine spatial resolutions, which is ...
    • Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement 

      Stevens, Gretchen A.; Alkema, Leontine; Black, Robert E.; Boerma, J. Ties; Collins, Gary S.; Ezzati, Majid; Grove, John T.; Hogan, Daniel R.; Hogan, Margaret C.; Horton, Richard; Lawn, Joy E.; Marušić, Ana; Mathers, Colin D.; Murray, Christopher J. L.; Rudan, Igor; Salomon, Joshua A.; Simpson, Paul J.; Vos, Theo; Welch, Vivian (Public Library of Science, 2016)
      Gretchen Stevens and colleagues present the GATHER statement, which seeks to promote good practice in the reporting of global health estimates.
    • Incidence of AIDS-Defining Opportunistic Infections and Mortality during Antiretroviral Therapy in a Cohort of Adult HIV-Infected Individuals in Hanoi, 2007-2014 

      Tanuma, Junko; Lee, Kyu Ha; Haneuse, Sebastien; Matsumoto, Shoko; Nguyen, Dung Thi; Nguyen, Dung Thi Hoai; Do, Cuong Duy; Pham, Thuy Thanh; Nguyen, Kinh Van; Oka, Shinichi (Public Library of Science, 2016)
      Background: Although the prognosis for HIV-infected individuals has improved after antiretroviral therapy (ART) scale-up, limited data exist on the incidence of AIDS-defining opportunistic infections (ADIs) and mortality ...
    • Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men 

      Meyer, Haakon E.; Støer, Nathalie C.; Samuelsen, Sven O.; Blomhoff, Rune; Robsahm, Trude E.; Brustad, Magritt; Giovannucci, Edward L.; Bjørge, Tone (Public Library of Science, 2016)
      Objective: A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested ...
    • Novel Ordered Stepped-Wedge Cluster Trial Designs for Detecting Ebola Vaccine Efficacy Using a Spatially Structured Mathematical Model 

      Diakite, Ibrahim; Mooring, Eric Q.; Velásquez, Gustavo E.; Murray, Megan B. (Public Library of Science, 2016)
      Background: During the 2014 Ebola virus disease (EVD) outbreak, policy-makers were confronted with difficult decisions on how best to test the efficacy of EVD vaccines. On one hand, many were reluctant to withhold a vaccine ...
    • Obesity and Mortality, Length of Stay and Hospital Cost among Patients with Sepsis: A Nationwide Inpatient Retrospective Cohort Study 

      Nguyen, Anh Tuan; Tsai, Chu-lin; Hwang, Lu-yu; Lai, Dejian; Markham, Christine; Patel, Bela (Public Library of Science, 2016)
      Objectives: The objective of this study was to examine the association between obesity and all-cause mortality, length of stay and hospital cost among patients with sepsis 20 years of age or older. Materials and Methods ...
    • Obstetric Facility Quality and Newborn Mortality in Malawi: A Cross-Sectional Study 

      Leslie, Hannah H.; Fink, Günther; Nsona, Humphreys; Kruk, Margaret E. (Public Library of Science, 2016)
      Background: Ending preventable newborn deaths is a global health priority, but efforts to improve coverage of maternal and newborn care have not yielded expected gains in infant survival in many settings. One possible ...
    • Quantifying Geographic Variation in Health Care Outcomes in the United States before and after Risk-Adjustment 

      Rosenberg, Barry L.; Kellar, Joshua A.; Labno, Anna; Matheson, David H. M.; Ringel, Michael; VonAchen, Paige; Lesser, Richard I.; Li, Yue; Dimick, Justin B.; Gawande, Atul A.; Larsson, Stefan H.; Moses, Hamilton (Public Library of Science, 2016)
      Background: Despite numerous studies of geographic variation in healthcare cost and utilization at the local, regional, and state levels across the U.S., a comprehensive characterization of geographic variation in outcomes ...