dc.contributor.author | Cruz-Guilloty, Fernando | |
dc.contributor.author | Pipkin, Matthew E. | |
dc.contributor.author | Djuretic, Ivana M. | |
dc.contributor.author | Levanon, Ditsa | |
dc.contributor.author | Lotem, Joseph | |
dc.contributor.author | Lichtenheld, Mathias G. | |
dc.contributor.author | Groner, Yoram | |
dc.contributor.author | Rao, Anjana | |
dc.date.accessioned | 2010-10-28T20:51:06Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Cruz-Guilloty, Fernando, Matthew E. Pipkin, Ivana M. Djuretic, Ditsa Levanon, Joseph Lotem, Mathias G. Lichtenheld, Yoram Groner, and Anjana Rao. 2009. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. The Journal of Experimental Medicine 206:51-59. | en_US |
dc.identifier.issn | 0022-1007 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4513850 | |
dc.description.abstract | Activation of naive CD8+ T cells with antigen induces their differentiation into effector cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of lytic granules containing the pore-forming protein perforin and a family of proteases termed granzymes. We show that effector CTL differentiation occurs in two sequential phases in vitro, characterized by early induction of T-bet and late induction of Eomesodermin (Eomes), T-box transcription factors that regulate the early and late phases of interferon (IFN) γ expression, respectively. In addition, we demonstrate a critical role for the transcription factor Runx3 in CTL differentiation. Runx3 regulates Eomes expression as well as expression of three cardinal markers of the effector CTL program: IFN-γ, perforin, and granzyme B. Our data point to the existence of an elaborate transcriptional network in which Runx3 initially induces and then cooperates with T-box transcription factors to regulate gene transcription in differentiating CTLs. | en_US |
dc.description.sponsorship | Molecular and Cellular Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The Rockefeller University Press | en_US |
dc.relation.isversionof | doi:10.1084/jem.20081242 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626671/pdf/ | en_US |
dash.license | LAA | |
dc.title | Runx3 and T-box Proteins Cooperate to Establish the Transcriptional Program of Effector CTLs | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | The Journal of Experimental Medicine | en_US |
dash.depositing.author | Rao, Anjana | |
dc.date.available | 2010-10-28T20:51:06Z | |
dc.identifier.doi | 10.1084/jem.20081242 | * |
dash.contributor.affiliated | Rao, Anjana | |