Browsing FAS Theses and Dissertations by Title
Now showing items 1259-1278 of 6138
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Discovery and Characterization of the Cylindrocyclophane Biosynthetic Pathway
(2016-05-17)Nature constructs structurally diverse, bioactive molecules using enzymes. Many enzymes catalyze synthetically challenging reactions under mild, physiological conditions. Consequently, they have long been a source of ... -
Discovery and characterization of the ligands of NK-cell receptors implicated in human diseases
(2016-08-31)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that act as first-line defenders against intracellular pathogens. Their functions are dictated by germline-encoded activating and inhibitory ... -
The Discovery and Characterization of the lncRNA Firre
(2015-05-08)RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ... -
Discovery and Development of Novel Deubiquitinase Inhibitors via Parallel High-Throughput Screening
(2022-11-23)Ubiquitination is a critical post-translational modification in cell biology which results in a myriad of functional outcomes including proteasomal degradation of substrate proteins. The regulation of protein homeostasis ... -
Discovery and Functional Interpretation of Genetic Risk in Autoimmune Diseases
(2015-05-08)Autoimmune diseases are chronic and debilitating conditions arising from abnormal immune responses directed against normal body tissues; they collectively affect the lives of 5-10% of the world population. These diseases ... -
Discovery and In Vivo Characterization of Long Noncoding RNAs
(2016-05-17)The noncoding genome, or the portion of the genome that does not encode for proteins, encompasses >95% of the human genome. It has been found that the majority of disease-associated genetic variants identified by genome-wide ... -
Discovery of a dynamically unstable actin homolog, Salactin, through advances in Haloarchaeal imaging
(2023-05-15)Archaea are fascinating extremophilic microorganisms that hold great potential for discoveries in cellular biology. Despite progress made in understanding the archaeal domain through metagenomic, biochemical, and structural ... -
Discovery of a Small Molecule That Inhibits D-Alanylation of Teichoic Acids in Staphylococcus Aureus
(2015-05-12)The Staphylococcus aureus cell envelope is a large, complex structure essential for cell shape and protection from the environment. It consists of membrane lipids, glycan polymers, and proteins, many of which have not been ... -
Discovery of bioactive lipids and lipid pathways in cell death and disease
(2014-06-06)Apoptosis is an intricately regulated cellular process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose ... -
Discovery of cancer vulnerabilities in gene expression regulation pathway
(2023-12-11)Cancer is one of the leading causes of death and many researchers are working on combating cancer. Despite significant progress in cancer therapeutics, many cancers still lack targeted therapies and new ways to enhance the ... -
Discovery of Giant Gamma-ray Bubbles in the Milky Way
(2012-08-09)Based on data from the Fermi Gamma-ray Space Telescope, we have discovered two gigantic gamma-ray emitting bubble structures in our Milky Way (known as the Fermi bubbles), extending \(\sim 50\) degrees above and below the ... -
Discovery of highly selective inhibitors to probe the physiology of the bacterial cell envelope
(2022-05-11)Traditional high-throughput screening approaches have failed to efficiently discover specific, biologically active inhibitors for use as probes and development into therapeutics. New strategies are therefore required to ... -
Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome
(2013-02-19)The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ... -
Discovery of Novel Molecular Glues and Targeted Protein Degradation Mechanisms for Cancer Therapeutics
(2023-05-03)Targeted protein degradation has emerged as a promising therapeutic approach that recruits cellular degradation machineries to induce degradation of target proteins. However, the mechanisms underlying many small molecule ... -
Discovery of Small-Molecule Autophagy Modulators in Mammalian Systems
(2016-06-07)Autophagy is an evolutionarily conserved catabolic process in eukaryotes, which involves the formation of double-membrane vesicles that enclose cellular components and fuse with lysosomes. Autophagy is critical to the ... -
Discovery of smoking-related biomarkers for advanced treatment in non-small cell lung cancer (NSCLC)
(2022-03-17)Lung cancer is one of the most diagnosed cancers and the leading cause of cancer death globally. Up to 60% of the non-small cell lung cancer lung (NSCLC) cancer patients are diagnosed with distant metastases with a poor ... -
Discrete Differential Geometry and Physics of Elastic Curves
(2013-10-17)We develop a general computational model for a elastic rod which allows for extension and shear. -
Discriminative Sequence Models Extract Personally Identifiable Information from Public Gene Expression Datasets
(2022-05-25)The growing scale of functional genomics datasets is enabling researchers to better understand the genetic determinants of gene expression, for example through expression quantitative trait loci (eQTL) studies. With an ... -
Disease and Desire: Perspectives on Addiction from Ancient Greek Poetry, Philosophy, and Medicine
(2022-06-06)This dissertation investigates addiction in the ancient Greco-Roman world, a phenomenon which I show not only existed in the ancient past, but was also conceptualized in unique ways. Based on a method that balances biological ... -
Disentangling the Coevolutionary Histories of Animal Gut Microbiomes
(2015-05-17)Animals associate with microbes in complex interactions with profound fitness consequences. These interactions play an enormous role in the evolution of both partners, and recent advances in sequencing technology have ...