Browsing FAS Theses and Dissertations by Title
Now showing items 1359-1378 of 6566
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Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome
(2013-02-19)The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ... -
Discovery of Novel Molecular Glues and Targeted Protein Degradation Mechanisms for Cancer Therapeutics
(2023-05-03)Targeted protein degradation has emerged as a promising therapeutic approach that recruits cellular degradation machineries to induce degradation of target proteins. However, the mechanisms underlying many small molecule ... -
Discovery of Small-Molecule Autophagy Modulators in Mammalian Systems
(2016-06-07)Autophagy is an evolutionarily conserved catabolic process in eukaryotes, which involves the formation of double-membrane vesicles that enclose cellular components and fuse with lysosomes. Autophagy is critical to the ... -
Discovery of smoking-related biomarkers for advanced treatment in non-small cell lung cancer (NSCLC)
(2022-03-17)Lung cancer is one of the most diagnosed cancers and the leading cause of cancer death globally. Up to 60% of the non-small cell lung cancer lung (NSCLC) cancer patients are diagnosed with distant metastases with a poor ... -
Discovery of ultra-low-signal variants to study human evolution and epilepsy
(2024-05-31)Next-generation sequencing (NGS) has revolutionized research on human evolution and brain-related diseases. With DNA-sequencing data available from humans at different time periods and affected tissues in the disease of ... -
Discrete Differential Geometry and Physics of Elastic Curves
(2013-10-17)We develop a general computational model for a elastic rod which allows for extension and shear. -
Discriminative Sequence Models Extract Personally Identifiable Information from Public Gene Expression Datasets
(2022-05-25)The growing scale of functional genomics datasets is enabling researchers to better understand the genetic determinants of gene expression, for example through expression quantitative trait loci (eQTL) studies. With an ... -
Disease and Desire: Perspectives on Addiction from Ancient Greek Poetry, Philosophy, and Medicine
(2022-06-06)This dissertation investigates addiction in the ancient Greco-Roman world, a phenomenon which I show not only existed in the ancient past, but was also conceptualized in unique ways. Based on a method that balances biological ... -
Disentangling the Coevolutionary Histories of Animal Gut Microbiomes
(2015-05-17)Animals associate with microbes in complex interactions with profound fitness consequences. These interactions play an enormous role in the evolution of both partners, and recent advances in sequencing technology have ... -
Disentangling the Roles of Form and Motion in Fish Swimming Performance
(2017-05-11)A central theme of comparative biomechanics is linking patterns of variation in morphology with variation in locomotor performance. This presents a unique challenge in fishes, given their extraordinary morphological diversity ... -
Disordered proteins regulate stress- & damage-dependent DNA binding
(2023-01-18)Three-dimensional structure has been used as a starting point to characterize protein function since the advent of X-ray crystallography in the 1950s. However, not all proteins bear stable tertiary or even secondary ... -
Disorientations. Latin American Fictions of East Asia
(2014-06-06)This dissertation explores the relationship between fiction, knowledge and "knowing" in Latin American discourses of China and Japan. By scrutinizing Brazilian and Hispanic American travel journals, novels, short stories ... -
disparate space, shared space
(2017-05-12)This dissertation is the result of seven years of creative work, during which ten new musical compositions were conceived, produced, and premiered. Eight of these are represented herein. A portfolio of works brought into ... -
Disposable Subjects: Law and Child Migration to the United States, 1890s-1920s
(2022-03-17)Disposable Subjects argues that foreign-born minors at the US border found themselves increasingly at the disposal of others, first and foremost the state, from the late nineteenth century to the 1920s. It explores the ... -
Disputing the Acoustic Territory: Politics of Sound and Sonic Order in 16th and 17th century Mexico City
(2023-06-01)Disputing the Acoustic Territory examines the importance of urban sounds—such as bell ringings, town criers, market bustles, and street musicians—in marking communal rhythms, controlling individuals’ sense of time, and ... -
Disruption of mammalian SWI/SNF chromatin remodeler function in human disease
(2023-11-21)The regulation of chromatin architecture and accessibility is central to the control of gene expression programs that govern cellular identity, cell fate and lineage commitment, differentiation, and responses to stimuli. ... -
Disruption of Mitochondrial Dynamics in Tauopathy
(2013-02-06)Alzheimer’s disease (AD) is characterized pathologically by proteinaceous aggregates composed primarily of amyloid \(\beta (A \beta)\) and tau. Diseases characterized by abnormal deposition of tau are collectively termed ... -
Dissecting and Targeting the PUMA and OLIG2 Control Points of Tumors of Neuroectodermal Origin with Stapled Peptides
(2013-09-30)Tumors of neuroectodermal origin are among the most aggressive and treatment-refractory forms of human cancer. While such tumors arise from a variety of defects, two key targets are the transcription factors p53 and OLIG2. ... -
Dissecting Molecular Mechanisms of Shigella flexneri Cell-to-cell Spread
(2014-10-21)Shigella is a causative agent of bacillary dysentery in humans. The ability of Shigella to disseminate in the intestinal epithelium is crucial for disease establishment. This process of cell-to-cell spread involves actin-based ... -
Dissecting Molecular Similarities and Differences Between Pluripotent Stem Cell Lines
(2015-05-16)Traditionally, pluripotent stem cells are derived from preimplantation embryos and fetal germ cells, which give rise to embryonic stem cells (ESCs) and embryonic germ cells (EGCs), respectively, In contrast, induced ...