Browsing FAS Theses and Dissertations by Title
Now showing items 5287-5306 of 6138
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T Cell Help Shapes B Cell Tolerance
(2023-11-21)Maintenance of B cell tolerance allows organisms to defend against pathogens without attacking their own tissues. Loss of B cell tolerance leads to autoimmune disease driven by the accumulation of pathogenic autoantibodies. ... -
Tackling Magnetic Active Regions in Radial Velocities: Strategies to Improve and Expand Small Exoplanet Mass Measurements
(2022-09-08)Several big-picture goals of exoplanet science now depend on building a population of small exoplanets that are well-characterized, having both a measured radius and a measured mass. Radii have been measured for approximately ... -
Tailoring Carbon Materials for Next-Generation Desalination
(2018-04-17)Mounting stressors to existing water supplies, whether by increased human consumption or changing environmental conditions, are creating water shortages worldwide. Consequently, meeting future water demand will require ... -
Taking Flight: Overcoming Challenges in Airport Development
(2021-07-12)How is it possible to overcome the challenges of providing public goods that create significant negative local externalities? Sometimes called ‘public bads,’ these goods are characterized by the combination of dispersed ... -
Taking Refuge in the Law: Monastic Litigation and a New History of Buddhism in Chosŏn Korea (1392-1910)
(2021-04-23)This dissertation examines the active legal role of Buddhist monastics in the society of Chosŏn Korea (1392-1910). Chosŏn is thought to have been particularly successful in using the law to advance Neo-Confucianism and ... -
Taking Up Space: Youth Culture and Creative Resistance in a Gentrifying City
(2022-05-12)Deepening inequalities and existential uncertainty in communities across the globe have coincided with calls to enact a more culturally sustaining vision of education. These calls are increasingly pressing in urban ... -
Talk Matters: Three Essays on the Strategic Use of Public Speech in Parliamentary Politics
(2021-05-17)Does political speech serve a purpose beyond merely articulating political positions? Until recently, scholars have treated the language politicians use in public – in parliamentary debates, in media appearances, or at ... -
Taming the Gypsy: How French Romantics Recaptured a Past
(2014-10-21)In this dissertation, I examine the evolution of the Gypsy trope in Romantic French literature at a time when nostalgia became a powerful aesthetic and political tool used by varying sides of an ideological war. Long ... -
Targeted Measurement and Manipulation of Hydrogen Peroxide in the Cardiovascular System
(2017-08-24)Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) with a diverse range of reported roles in both normal physiology and disease. While H2O2 and other ROS have long been reported to be drivers of acute and chronic ... -
Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas
(2014-06-06)With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted ... -
Targeting FGFR to Overcome EMT-Related Resistance to EGFR Inhibition in EGFR-Mutated Non-Small Cell Lung Cancer
(2018-01-19)Acquired drug resistance to tyrosine kinase inhibitor (TKI) targeted therapies remains a major clinical challenge. In EGFR mutant non-small cell lung cancer (NSCLC), therapeutic failure of EGFR TKIs can result from both ... -
Targeting of proteins from the endoplasmic reticulum to lipid droplets: a specific requirement for mitochondrial proteins
(2021-07-12)Neutral lipid storage and metabolism in lipid droplets (LDs) is integral to energy homeostasis in eukaryotic cells. Dysregulation of LDs has been implicated in metabolic diseases including obesity and dyslipidemia. Proteins ... -
Targeting the Calcineurin-NFAT Interaction by Solution NMR Spectroscopy
(2015-01-13)The serine/threonine phosphatase calcineurin (Cn) targets the nuclear factors of activated T cells (NFATs) that activate cytokine genes. Calcium influx activates Cn to dephosphorylate multiple serine residues within the ... -
Targeting the CD4- and Coreceptor-Binding Sites of the HIV-1 Envelope Glycoprotein
(2014-06-06)The HIV-1 envelope glycoprotein, Env, facilitates the translocation of the viral capsid across the cellular membrane. Env is a trimer of hetero-dimers composed of a gp120 subunit and gp41 transmembrane protein. The gp120 ... -
Targeting the ClpC1 ATPase for antibiotic development in Mycobacterium tuberculosis
(2023-05-01)Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis (Mtb). It remains a leading cause of death due to infectious disease globally, with over ten million new cases yearly. TB treatment requires ... -
Targeting the Epigenetic Lesion in MLL-Rearranged Leukemia
(2013-03-18)It has become increasingly apparent that the misregulation of histone modification actively contributes to cancer. The histone H3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias ... -
Targeting the PI3K/AKT Pathway using Pan-AKT Degraders
(2022-06-06)The serine/threonine protein kinase AKT, a downstream effector of phosphoinositide 3-kinase (PI3K), is a critical regulator of numerous cellular processes including proliferation, survival, metabolism, and apoptosis. Genetic ... -
Task-Dependent Mouse Behavioral Dynamics in Navigational Decision-Making
(2023-11-21)Effective navigation in their environment requires animals to process and integrate diverse inputs across varying timescales while adaptively responding to their surroundings. This ability to integrate information over a ... -
Taxation, Corruption, and Engagement With the Formal State: Experimental Evidence From the D.R. Congo
(2018-05-13)Few countries achieve peace and prosperity without a capable and accountable government. Political scientists and historians have documented the consolidation of modern nation states in Europe, and the emergence of accountable ... -
TBK1 deficiency leads to TDP-43 pathology driven by endo-lysosomal dysfunction in human-induced motor neurons
(2022-04-25)Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron loss accompanied by cytoplasmic localization of TDP-43 proteins and their insoluble accumulations. Over the past decades, ...