Browsing FAS Theses and Dissertations by Title
Now showing items 6128-6138 of 6138
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Z-DNA underlies the target choice of Aire by facilitating promoter poising
(2023-11-21)Aire is an unconventional transcriptional regulator that upregulates the expression of thousands of genes encoding peripheral tissue antigens in medullary thymic epithelial cells (mTECs), which promotes clonal deletion or ... -
Zebrafish Immune Cell Development and Diversity in Health and Disease
(2022-06-06)Hematopoiesis, the process by which all blood cells are generated, is directed by transcription factors and signaling pathways that are highly conserved between zebrafish and humans. In healthy individuals, hematopoietic ... -
A Zebrafish Model of Uveal Melanoma
(2015-05-06)Uveal melanoma is the most common primary intraocular tumor in adults, and is often characterized by poor prognosis and few effective therapeutic options. The typical site of metastasis for uveal melanoma is the liver, and ... -
Zebrafish Models of Congenital Myopathy
(2015-08-31)The congenital myopathies are a diverse group of inherited neuromuscular disorders that manifest as skeletal muscle weakness at birth or in infancy, and are classically defined by the predominant morphological features ... -
Zero Knowledge Proofs and Applications to Financial Regulation
(2018-06-29)We consider zero-knowledge proofs, a class of cryptographic protocols by which an agent (a Prover) can prove to another agent (a Verifier) that a statement is true without revealing any additional information. For example, ... -
Zero-Index Metamaterials: A New Phase in Integrated Optics
(2018-09-25)Metamaterials with a refractive index of zero exhibit properties that are important for integrated optics. Possessing an infinite effective wavelength and zero spatial phase change, zero-index metamaterials may be especially ... -
ZNF335: A Novel Regulator of Stem Cell Proliferation and Cell Fate in the Cerebral Cortex
(2013-03-18)Though development of the cerebral cortex is of singular importance to human cognition, it remains very poorly understood. Microcephaly, or "small head," is a neurodevelopmental disorder causing significantly reduced ... -
Zoom or Bust?: An Exploration into Remote Work Productivity and Best Practices
(2022-05-23)COVID-19 pushed millions of workers from the office to Zoom. With remote work becoming the new normal, firms and employees alike continue to wonder about the benefits or drawbacks to remote work on overall productivity. ... -
Zooming in on the Chemistry of Star and Planet Formation
(2023-05-09)The dust- and gas-rich environments of protoplanetary disks provide the raw materials needed for forming planets. The molecular gas and associated chemistry are directly tied to the resulting exoplanet architectures, ... -
Zooming into earthquake ruptures: from kinematics to dynamic
(2022-01-14)Earthquakes, especially the large ones, cause huge hazards and threaten people living nearby. It is important to improve our understanding of the earthquake source process. I do so by combining seismic data, observations, ... -
α-Synuclein Induces Mitochondrial Dysfunction Through Spectrin and the Actin Cytoskeleton
(2018-09-16)Abnormal accumulation of the cytoplasmic protein α-synuclein in vulnerable neurons and glial is a pathological hallmark of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, collectively termed ...