Browsing FAS Theses and Dissertations by Title
Now showing items 1049-1068 of 6136
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Deduplication on Large Family Datasets
(2016-07-06)Thanks to new technology, data collection of family pedigree charts can be instantly collected from cancer clinics. As in common practice, individuals with high risk of cancer are frequently resampled for further checkups ... -
Deep Eutectic-Mediated Parenteral Drug Delivery Systems for Therapeutic Macromolecules
(2023-06-01)The past 100 years have seen an evolution of drug payloads that have expanded the number of treatment options for an increasing number of treatable diseases. With this progression, it has become increasingly necessary to ... -
Deep Learning for Inverse Problems in Engineering and Science
(2023-05-11)In a famous Socratic dialogue by Plato, Meno postulates that the epistemic pursuit of knowledge demands a target, without which one cannot determine the object of inquiry or even recognize it upon discovery. The paradox ... -
Deep Learning Models for Variant Pathogenicity Prediction
(2021-06-04)Technological advancements in DNA sequencing have made it a mainstay in the clinic in the form of targeted genetic testing as well as whole exome and whole genome sequencing (WES and WGS, respectively). With increased use ... -
Deep Sequencing and Functional Analyses Identify a Role of Fusobacterium Species in Colorectal Tumorigenesis
(2013-09-30)The tumor microenvironment is a complex community consisting of neoplastic cells, surrounding stromal cells, a broad array of immune cells, and a microbiota. By sheer numbers, the microbiota has its greatest manifestation ... -
Deep Solidarity: Political Theology, Jewish Thought, and Liberal Commitment in a Secular Age
(2016-09-16)Solidarity is crucial for liberalism. It helps to stabilize society, realize justice, diminish domination, and cultivate moral personality. Yet the sources of liberal solidarity have received almost no attention in ... -
Defects in Hard-Sphere Colloidal Crystals
(2013-03-15)Colloidal crystals of \(1.55 \mu m\) diameter silica particles were grown on {100} and flat templates by sedimentation and centrifugation. The particles interact as hard spheres. The vacancies and divacancies in these ... -
Define the RelationSHIP: INPP5D/SHIP1 regulates inflammasome activation in human microglia
(2022-09-09)Microglia and neuroinflammation are implicated in the development and progression of Alzheimer’s disease (AD). However, there are limitations to studying human microglia and utilizing mouse models to study microglia function. ... -
Defining a Role for T Regulatory Cell Expressed MyD88 During the Response to Allografts
(2015-11-16)The myeloid differentiation primary response gene 88 (MyD88) is an adaptor protein proximally downstream of the Toll-like receptor (TLRs) and the IL-1 receptor family (IL-1R, IL- 18R and IL-33R). The TLR-MyD88 signaling ... -
Defining Anabolic Functions of ATF4 as a Downstream Effector of mTORC1 Signaling
(2021-05-12)In response to a variety of upstream growth and oncogenic signals, the mechanistic target of rapamycin complex 1 (mTORC1) promotes anabolic metabolism, in part, through activation of downstream transcription factors. ... -
Defining and Targeting Transcriptional Pathways in Leukemia Stem Cells
(2014-10-21)Acute myeloid leukemia (AML) is a clonal neoplastic disorder organized as a cellular hierarchy, with the self-renewing leukemia stem cell (LSC) at the apex. Recurrent mutations in transcription factors (TF) and epigenetic ... -
Defining Diversity: Professionals and Institutionalization Processes
(2015-01-23)This dissertation is a qualitative study of the field of corporative diversity management, based on in-depth interviews with diversity managers and human resource managers at 87 firms across the United States. My work ... -
Defining Female Achievement: Gender, Class, and Work in Contemporary Korea
(2018-05-11)Understanding how women transition to adulthood and make decisions about family, employment, and parenting have long been central questions in gender and family scholarship. Korea offers a particularly compelling context ... -
Defining markers and mechanisms of human somatic cell reprogramming
(2014-02-25)Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by over expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Using serial live cell immunofluorescence imaging of human fibroblasts ... -
Defining the biochemical functions of the TSC complex and its regulation of Rheb-mTORC1 signaling
(2023-05-12)Nutrients and growth factors are sensed by a ubiquitous signaling network that converges on the protein kinase complex mechanistic target of rapamycin (mTOR) complex 1 (mTORC1). mTORC1 functions to integrate a diverse set ... -
Defining the crosstalk between the transcription and splicing machineries
(2024-03-12)Production of mammalian messenger RNAs (mRNAs) often requires RNA Polymerase II (RNAPII) to transcribe tens of kilobases and coordinate the co-transcriptional removal of multiple introns by the spliceosome. The expansion ... -
Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis
(2016-05-14)Despite its eponymous association with proteotoxic stress, heat shock factor 1 (Hsf1 in yeast and HSF1 in mammals) is required for viability of yeast and many human cancer cells, yet its essential role remains undefined. ... -
Defining the Landscape of the PARKIN- and PINK1-Dependent Ubiquitin-Modified Proteome in Response to Mitochondrial Dysfunction
(2013-09-26)Parkinson's disease (PD) is a progressive neurological disorder resulting from loss of dopaminergic neurons of the substantia nigra, in part due to mitochondrial dysfunction. The E3 ubiquitin ligase, PARKIN, and mitochondrial ... -
Defining the Ubiquitin and E2-Enzyme Requirements for APC/C-Mediated Degradation of Cyclin B1
(2012-09-12)Post-translational modification of proteins with ubiquitin regulates many aspects of cell physiology, including protein degradation. A uniform polyubiquitin chain that is linked through Lys48 has been widely accepted as ... -
Defining tissue-specific developmental requirements for the proteasome
(2023-12-06)The ubiquitin-proteasome system provides a rapid, temporally controlled, and highly specific mechanism for intracellular protein degradation. As part of its role in degrading short-lived regulatory proteins, the proteasome ...