Browsing FAS Theses and Dissertations by Title
Now showing items 1376-1395 of 6136
-
The Dynamics and Evolution of Supermassive Black Holes in Merging Galaxies
(2012-08-03)This thesis is a theoretical study of supermassive black holes (SMBHs) in merging galaxies. We consider the dynamics that govern inspiralling SMBH pairs and gravitational-wave (GW) recoiling SMBHs, as well as the fueling ... -
Dynamics and Materials Physics of Fault Rupture and Glacial Processes
(2015-01-23)This thesis focuses on two main topics, the physics governing how faults rapidly weaken during an earthquake and the thermal and mechanical structure of ice stream shear margins. The common theme linking these two projects ... -
Dynamics and spatiotemporal organization of mammalian SWI/SNF chromatin remodeling complexes in transcriptional regulation
(2023-06-01)ATP-dependent chromatin remodeling complexes play critical roles in the maintenance of tissue- and state-specific chromatin structure; however, the spatial organization and dynamics of these remodelers, as well as their ... -
Dynamics and topology of absolute period foliations of strata of holomorphic 1-forms
(2022-05-12)Let $S_g$ be a closed oriented surface of genus $g$, and let $\Omega\mathcal{M}_g(\kappa)$ be a stratum of the moduli space of holomorphic $1$-forms of genus $g$. In this thesis, we study dynamical and topological properties ... -
Dynamics in Biological Soft Materials
(2014-02-25)I present applications of imaging and spectroscopy to understand mechanical, chemical, and electrical dynamics in biological materials. The first part describes the development and characterization of a protein-based ... -
Dynamics of Algorithmic Fairness
(2022-05-11)The rise of machine learning-based predictive models in making decisions of profound social impact has spurred study of those technical properties that may bear on the moral and political character of their deployment. One ... -
Dynamics of Charged Colloids in Nonpolar Solvents
(2013-09-04)Charging is typically not expected in nonpolar environments due to a high electrostatic barrier to charge dissociation. Nevertheless, charge effects are observed in such environments upon the addition of surfactants, which ... -
Dynamics of Cortical Decision Circuits during Changes in the Fidelity of Sensory Representations
(2012-10-23)Every waking moment, we make decisions, from where to move our eyes to what to eat for dinner. The ease and speed with which we do this belie the complexity of the underlying neuronal processing. In the visual system, every ... -
Dynamics of HIV treatment and social contagion
(2013-10-08)Modern-day management of infectious diseases is critically linked to the use of mathematical models to understand and predict dynamics at many levels, from the mechanisms of pathogenesis to the patterns of population-wide ... -
Dynamics of infection, mutation, and eradication, in HIV and other evolving populations
(2013-10-08)This work uses mathematical models of evolutionary dynamics to address clinical questions about HIV treatment, public health questions about vaccination, and theoretical questions about evolution of high mutation rates. -
Dynamics of Neural Activity During Chemotaxis in Caenorhabditis Elegans
(2015-09-28)The nervous system of an animal must control and coordinate locomotion in a changing and often unpredictable environment in order to survive. When a Caenorhabditis elegans navigates its environment, the nervous system can ... -
Dynamics of p53 tetramers in live single cells
(2014-06-06)Protein homo-oligomerization is the process through which identical peptides bind together to form higher order complexes. Self-interactions in many cases are constitutive and stable, used as building blocks for biological ... -
Dynamics of protein evolution within complex biophysical constraints
(2017-03-03)Proteins evolve within complex biophysical constraints. Natural selection promotes the survival of the fittest organisms. Therefore, protein variants that decrease organismal fitness are likely to go extinct along with the ... -
Dynamics of surfaces and interfaces: From first-principles modeling to machine-learning molecular dynamics
(2022-05-10)Chemical production accounts for a substantial fraction of global energy use, and the majority of industrial processes rely heavily on precious metal heterogeneous catalysts. Fundamental knowledge of the surface structure ... -
Dynamics of Tissue-Resident Regulatory T Cell Populations
(2014-06-06)In recent years, there has been a worldwide increase in obesity, which parallels a rise in pathologies, including type 2 diabetes, collectively termed the metabolic syndrome. Chronic, low-grade inflammation has been ... -
Dynamics of Westerly Wind Bursts and Western US Climate over the Past 5 Million Years
(2022-05-13)This dissertation covers investigations of the dynamics of Westerly Wind Bursts (WWBs), as well as the hydrological cycle, atmospheric circulation, and sea surface temperatures of the early-to mid-Pliocene (5.3-3 Ma) and ... -
Dysregulation of developmental transcription factor programs in Merkel cell carcinoma
(2022-06-06)Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) carcinoma of the skin for which targeted therapeutic approaches and improved subtype classification are sorely needed. MCC is usually treated in a relatively ... -
Dysregulation of Host Cellular microRNA Expression by the Human Papillomavirus E6 and E7 Oncoproteins
(2017-05-12)Human papillomaviruses (HPVs) are small DNA viruses with a tropism for squamous epithelia. Nearly all cervical cancers are caused by a small group of high-risk HPVs and these viruses are also associated with anal, vaginal, ... -
Dysregulation of mSWI/SNF (BAF) Complexes in Human Malignancy
(2021-11-16)Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit, ATP-dependent, chromatin-remodeling protein complexes that increase the accessibility of DNA to transcriptional machinery. BAF complex perturbations are found ... -
E-Park: Automated-Ticketing Parking Meter System
(2015-06-26)E-Park is an electronic parking meter system which enables real-time ticketing of illegally parked vehicles. The system is a drop-in replacement for existing curb-side parking meters. It consists of lowpower front-end ...