Browsing FAS Theses and Dissertations by Title
Now showing items 913-932 of 6136
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Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid
(2014-02-25)Following human immunodeficiency virus (HIV-1) entry into the host cell, the viral capsid gradually disassembles in a process called uncoating. A proper rate of uncoating is important for reverse transcription of the HIV-1 ... -
Contribution of SORL1 in human iPSC-derived neurons and astrocytes to Alzheimer’s disease pathogenesis
(2022-09-06)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with heterogeneous etiology as suggested by genetic, neuropathological, and clinical evidence. Induced pluripotent stem cell (iPSC) technology can serve ... -
Contributions to Design and Analysis of Pediatric HIV Studies
(2023-05-11)Youth with perinatal HIV exposure have demonstrated higher rates of emotional---behavioral problems than the general US youth population. However, more evidence is needed to help target prevention and intervention efforts ... -
Contributions to Imputation Methods Based on Ranks and to Treatment Selection Methods in Personalized Medicine
(2013-02-14)The chapters of this thesis focus two different issues that arise in clinical trials and propose novel methods to address them. The first issue arises in the analysis of data with non-ignorable missing observations. The ... -
Contributions to Quantum Control and Statistical Physics
(2021-05-13)This thesis consists of two parts. The first part is on the complexity of controlling quantum systems. Specifically, we present results on sufficient conditions under which control of quantum systems is efficient. We ... -
Contributions to Scalable Bayesian Computation
(2022-05-10)This manuscript presents four projects related to Bayesian computation in large-scale settings. Each chapter is self-contained, and their respective abstracts are given below. Chapter 1: Markov chain Monte Carlo (MCMC) ... -
Control and Optimization of Soft Exosuit to Improve the Efficiency of Human Walking
(2018-05-03)Researchers have strived to develop lower limb wearable devices to improve the efficiency of human walking, however significant device inertia, kinematic constraints and the lack of optimal control strategies has limited ... -
Control of Drosophila Courtship by Mating Drive
(2018-09-16)Most behaviors are not just actions and reactions, but are the result of self-evaluation and are the means of self-fulfillment. This means that the same external context (e.g. food) can hold different meaning to an animal ... -
Control of HIV-1C Replication Both in Vivo and in Vitro
(2015-05-18)In this study, we established an HIV latency model using pluripotent stem cells in vitro. We found that a HIV accessory protein nef is responsible for full-length HIV silencing in human pluripotent stem cells. This effect ... -
Control of Neurotransmitter Release Properties by Presynaptic Calcium
(2014-06-06)Presynaptic terminals of neurons are optimized for neurotransmitter release, which is tightly controlled by presynaptic calcium. Here, we evaluate the role of calcium influx through voltage-gated calcium channels (VGCCs) ... -
Control of spin dynamics for applications in Nuclear Magnetic Resonance
(2013-10-17)Sophisticated electromagnetic pulse sequences that control spin dynamics have been developed in Nuclear Magnetic Resonance (NMR) over the last few decades. However, due to more and more demanding criteria, such as unknown ... -
Control of Turning Behaviors by Spinal Projection Neurons in the Larval Zebrafish
(2012-09-17)This thesis aims to examine how hindbrain spinal projection neurons (SPNs), namely RoV3, MiV1 and MiV2 control tail undulations during turning behaviors. I find that phototaxic turns differ from forward swims by an increased ... -
Controlling Atomic, Solid-State and Hybrid Systems for Quantum Information Processing
(2013-10-18)Quantum information science involves the use of precise control over quantum systems to explore new technologies. However, as quantum systems are scaled up they require an ever deeper understanding of many-body physics ... -
Controlling Cell Fate During Directed Differentiation of Human Beta Cells
(2023-06-01)Human beta cells derived from pluripotent stem cells have the potential to cure type 1 diabetes. Considerable progress has been made in differentiating insulin-secreting beta cells that can rescue animal models of diabetes, ... -
Controlling Compliance: Robotic Finger Design with Variable Stiffness for Deflections from the Target Position
(2023-06-30)In dexterous robotics, the available actuators are largely sorted into rigid or compliant actuators, which are characterized by strong or gentle grasps and by precise or simple controls, respectively. This division limits ... -
Controlling fluxes for microbial metabolic engineering
(2014-10-21)This thesis presents novel synthetic biology tools and design principles usable for microbial metabolic engineering. Controlling metabolic fluxes is essential for biological manufacturing of fuels, materials, and high value ... -
Controlling Gas Absorption in Liquids through Manipulation of Free Volume
(2023-03-14)The capture, storage, and transport of gases by liquids is integral to many biological, environmental, and industrial processes. The density of gas molecules dissolved within a liquid in equilibrium with a bulk gas phase ... -
Controlling the Supramolecular Assembly and Photophysical Properties of Atomically Precise Metal Chalcogenide and Noble Metal Nanoclusters
(2024-03-12)Noble metals such as gold and silver—when confined to the nanoscale (1–100 nm)—enable control of electromagnetic fields in the sub-wavelength size regime. This property has pioneered state-of-the-art technologies spanning ... -
Convergent Excitatory Pathways Mediate the Zebrafish Escape Behavior
(2015-05-14)Scientists have long been fascinated by how anatomical structures in the brain can generate the diversity of behaviors apparent in the animal kingdom. While the ultimate goal of neuroscience is to understand complex brain ... -
Convergent Interactions Among Pitcher Plant Microcosms in North America and Southeast Asia
(2016-08-03)Ecosystems are composed of diverse suites of organisms whose interactions are mediated by both the biotic and abiotic constraints of their environments. The complexity of ecosystems makes them both resilient and difficult ...