Browsing FAS Theses and Dissertations by Title
Now showing items 1179-1198 of 6138
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Development of nucleic acid detection methods for object provenance and viral diagnostics
(2021-11-16)Starting with the discovery of DNA structure, advances in molecular and systems biology in the past few decades have propelled nucleic acid amplification and detection technologies with far-reaching applications including ... -
Development of photonic crystal cavities to enhance point defect emission in silicon carbide
(2017-09-07)Silicon carbide (SiC) is a semiconductor with a long history of use in a range of fields, finding applications in optoelectronics, high-power electronic devices (like field-effect transistors), and microelectromechanical ... -
Development of Redox Organics for Aqueous Flow Batteries
(2021-07-12)The cost of solar and wind electricity has dropped so precipitously that the main barrier to their widespread adoption is their intrinsic intermittency. Aqueous organic redox flow batteries (AORFBs) provide a potentially ... -
Development of Small Molecule Kinase Degraders as Chemical Biology Probes and Cancer Therapies
(2018-09-20)Advances in chemical biology provide immense benefits to human health through the discovery of new medicines and new scientific tools to study disease. I have contributed to the advancement of this field by developing a ... -
Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering
(2014-10-21)Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of genome function. Analogous to the search function in modern word ... -
Development of Tin(II) Sulfide Solar Cells by Interface Engineering and Absorber Alloying
(2017-05-12)Tin(II) sulfide (SnS) is a promising candidate for alternative photovoltaic (PV) materials. Composed of cheap, non-toxic and earth-abundant elemental constituents, SnS has appropriate band gap and high absorption coefficient. ... -
Development, Aircraft Integration, and Field Deployment of a CO2 Herriott Cell to Measure Arctic Carbon Fluxes
(2017-01-13)The warming of the Arctic, as mediated by climate change, will precipitate a feedback effect. Should the carbon in soil be processed and emitted as the greenhouse gases CO2 and CH4, the feedback effect will be positive; ... -
Developmental and evolutionary origins of the crocodylian snout and amniote face
(2020-11-23)Crocodylians (alligators, crocodiles, and gharial) are instantly recognizable by their flattened skulls and tooth-filled jaws, adaptations which aid in capturing prey in shallow water and along riverbanks. A popular ... -
Developmental and Genetic Mechanisms of Ovariole Number Evolution in Drosophila
(2014-06-06)The goal of the "Quantitative Trait Gene" (QTG) program is to identify genes and mutations that underlie natural phenotypic variation. My goal with this work was to contribute an additional model to the program: ovariole ... -
Developmental Foundations of the Social Mind
(2023-06-01)Our understanding of others’ minds is central to human learning, cooperation, and social life more broadly. In the present dissertation, I examine the development and origins of humans’ abilities to reason about others’ ... -
Developmental Maturation within the Hematopoietic System
(2014-06-06)Stem cell biologists creating cells and tissues for therapies, disease modeling, and drug screening have observed that differentiating pluripotent stem cells (PSCs) tend to produce cells at an embryonic stage of development ... -
Developmental mechanisms underlying avian morphological evolution
(2023-05-12)Vertebrates have evolved remarkable morphological diversity over millions of years, from the smallest hummingbird to the largest whales, in response to natural selection. These endless forms, generated over the course of ... -
Developmental Origins of Aggressive Medulloblastoma
(2013-03-05)Medulloblastomas represent a heterogeneous group of cerebellar tumors that constitute the most frequent primary pediatric solid malignancy. Molecular characterization of these tumors have led to the understanding that ... -
The Developmental Origins of Logical Inference: Deduction and Domain-Generality
(2016-09-15)Is there a fundamental divide between the types of thoughts that human adults can entertain and those available to infants and nonhuman animals? The research in this dissertation explores the developmental origins of ... -
Developmentally-Inspired Engineering Of An Inductive Biomaterial for Odontogenesis
(2014-06-06)Increasing demands for organ transplants and the depleting supply of available organs has heightened the need for alternatives to this growing problem. Tissue engineers strive to regenerate organs in the future; however ... -
Developments in Control Authority for Flapping-Wing Micro-Aerial Vehicles
(2022-06-06)Bio-inspired flight at the insect scale encourages aspirations of unmatched speed and agility. However, flapping-wing micro-aerial vehicles are subject to unique challenges in control, including constraints in computation, ... -
Developments in Human Pluripotent Stem Cell Genome Engineering and in Situ Sequencing Technologies
(2015-05-19)Technology is a key driving force in the advancement of scientific discoveries. While DNA sequencing uncovered the blueprint of life encoded in the human genome, functional roles of sequence variants remain largely unknown. ... -
Developments of MERFISH for functional genomics and spatial epigenomics
(2022-06-06)The recent development of spatial omics methods, enables spatial profiling of transcriptome and 3D structure of genomes at a single-cell level. Expanding the repertoire of spatial omics tools, a spatial epigenomics method ... -
Device, Circuit, and Algorithm Co-Design for Efficient Neural Network Inference in Hardware
(2023-11-21)Artificial neural networks (ANN) using machine learning algorithms have achieved amazing performance in many artificial intelligent tasks. However, the hardware implementations of these ANNs are faced with two major ...