Browsing FAS Theses and Dissertations by Title
Now showing items 648-667 of 6138
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Cellular and Genetic Dynamics of the Melanoma Microenvironment
(2023-04-26)The tumor microenvironment is comprised of a diverse assemblage of cells. These populations dynamically interact with one another in varied ways that modify the individual cells and shape the overall trajectory of the ... -
Cellular and Molecular Mechanisms of Chronic Inflammation in Aging of Skeletal Muscle
(2015-05-13)Aging of skeletal muscle is typically accompanied by declining regenerative potential, due in part to alternations in the resident muscle stem cell population, known as satellite cells. Previous data suggest that highly ... -
Cellular and synaptic mechanisms controlling cerebellar output
(2021-05-13)The deep cerebellar nuclei (DCN) provide the major output of the cerebellum, projecting to premotor nuclei as well as non-motor areas in the brain. The dominant input to the DCN is provided by the output cells of cerebellar ... -
Cellular and Systemic Metabolic Adaptations to Energy Status
(2014-06-06)My thesis work has focused on physiological adaptations to nutrient stress; from genes, environment and hormonal perspective, and how failure of these systems result in common chronic diseases. -
Cellular Metabolism Modulates Ion Channels That Regulate Neuronal Excitability
(2015-05-01)Epilepsy is a common neurological disorder, affecting around 1% of the world’s population. For many, drugs are available that can prevent their seizures. However, for close to one third of those who suffer from epilepsy, ... -
Cellular Resolution Imaging in a Rodent Model for High-Level Vision
(2021-07-12)Vision is critical for guiding behavior in species throughout the animal kingdom. Nonhuman primates have long been classic models for vision, but over the last decade, rodents have emerged as highly promising alternatives. ... -
Cellular Targets of Propranolol in Infantile Hemangioma
(2014-02-25)Infantile hemangioma (IH) is a vascular neoplasm that affects 4-10 percent of infants. Propranolol, a non-selective beta-adrenergic receptor (AR) antagonist, was serendipitously discovered to accelerate regression of IH ... -
Central Control Circuit for Context-Dependent Micturition
(2016-12-13)Precise control of urine release (micturition) serves an essential physiological function, as well as a critical role in social communication in many animals. Here we show a combined effect of olfaction and social hierarchy ... -
Central role for Sonic hedgehog-triggered pericytes in hindbrain choroid plexus development
(2014-02-25)The choroid plexus is an organ within each brain ventricle comprised of elaborate folds of epithelium (CPe) and vasculature. It performs numerous functions essential for brain development and health, including secretion ... -
Centralized Management in Democratic Governance—Essays on Organizing a System of Executive Branch Bureaucracies
(2023-06-01)This dissertation contributes to our understanding of how non-elected government actors can manage and lead a system of executive branch government bureaucracies to better advance both administrative capacity and democratic ... -
Cerebral Data Structures: Integrating Context into Data Structure Design and Implementation
(2022-05-11)The speed at which computer programs execute operations is fundamental to the way we build applications, with faster performance lowering operational costs and creating better user experiences. In addition, faster performance ... -
Certainty and War
(2016-05-11)Does greater certainty about an adversary’s attributes cause peace? What states believe they can secure through force dictates the diplomatic settlements they will accept. In prevailing accounts which preclude assessment ... -
cGAS-like receptors in animal innate immunity
(2023-05-04)The molecular detection of pathogen infection and subsequent initiation of an immune response is an essential function of cellular life. Animals encode innate immune proteins known as PRRs (pattern-recognition receptors) ... -
Challenging Cooperation: Inequality, Global Commons, Future Generations
(2016-04-25)Cooperation is abundant in the world around us, spanning all levels of biological and social organisation. Yet the existence and maintenance of cooperation is puzzling from an evolutionary perspective because the costs ... -
Challenging the Dominant Currency? Exchange Rate Pass-Through in China's Importing Trades
(2017-10-13)I examine China’s import trade, in particular how China’s import prices fluctuate with movements in the exchange rate of Chinese currency RMB (yuan) against both international currencies such as the Euro and the US dollars ... -
Changing Climates: Deserts, Desiccation, and the Rise of Climate Engineering, 1870-1950
(2014-10-22)This dissertation examines the impact of the nineteenth-century discussions about climate change and desiccation on large engineering projects in desert regions between 1870 and 1950. It demonstrates that the debate over ... -
Channel Length Scaling in Microwave Graphene Field Effect Transistors
(2018-05-12)In order to operate at microwave frequencies and higher, the channel length of a field effect transistor must be made very short ($\sim25$nm at 1THz) to minimize input capacitance and the drift time of carriers through the ... -
Character before the Novel: Representing Moral Identity in the Age of Shakespeare
(2013-02-20)This dissertation argues that the modern concept of literary character was an unintended consequence of Renaissance moral poetics. The evolution of "character" as a term of literary analysis, from the rediscovery of ... -
Character displacement and community assembly in Anolis lizards
(2013-10-08)At broad scales, community ecologists study how biogeographic factors like environmental dissimilarity and geographic distance influence community assembly and composition. At small scales, community ecologists study how ... -
Characterization and Biocatalytic Potential of an Enzymatic Friedel–Crafts Alkylation from Cylindrocyclophane Biosynthesis
(2022-06-06)The cyanobacterial enzyme CylK assembles the cylindrocylophane natural products by performing two sequential Friedel–Crafts alkylation reactions, forming new alkyl–aryl carbon–carbon bonds between resorcinol nucleophiles ...