Person: Zhong, Qiuyue
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Publication Prevalence of chronic hepatitis B and status of HBV care among rural women who planned to conceive in China
(Nature Publishing Group UK, 2017) Wang, Yuanyuan; Zhou, Hong; Zhang, Long; Zhong, Qiuyue; Wang, Qiaomei; Shen, Haiping; Zhang, Man; Huang, Yanjie; Wang, Anqi; Nelson, Kenrad; Zhang, Yiping; Yan, Donghai; Peng, Zuoqi; Zhang, Ya; Xin, Xiaona; Zhang, Hongguang; Zhao, Jun; Wang, Yan; Yang, Ying; He, Yuan; Xu, Jihong; Liu, Xiaoli; Ma, XuGlobally, one third of prevalent chronic hepatitis B (CHB) virus infection (HBV) occurred in China. Assessing the prevalence of CHB infesction and status of HBV-related services among pre-conception women will provide insight into risks of mother to child transmission (MTCT). A cross-sectional analysis of data from the National Free Pre-pregnancy Checkups (NFPC) program in 2010–2014 was conducted. A standardized questionnaire which collected demographic information and enzyme-linked immunosorbent assays (ELISA) which tested serological HBV markers were applied. A total of 16,051,850 rural women aged 15–49 years were included. 5.2% of women were infected with CHB, among whom, 28.6% were also hepatitis B e antigen (HBeAg) positive. The most CHB concentrated places were distributed in southeastern coastal provinces. Women born after 1992 did not experience a higher level of vaccine-induced immunity compared to those born before 1992. Nine in ten rural women with CHB were not aware of their HBV status and a very small proportion of women (0.22%) had received antiviral treatment. Our data demonstrated an overall high-intermediate burden of CHB. Heterogeneity of geographic distribution, high proportion of HBeAg, insufficient awareness of HBV status, and low access to HBV treatment are challenges for preventing the MTCT.