Person:
Regev, Ido

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Regev

First Name

Ido

Name

Regev, Ido

Filters

2015 - 20172

Settings

Author's Publications: search.filters.isAuthorOfPublication.0321ae80-36e0-46bd-a351-2bb2ff9be0d3

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Publication
    Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock
    (Elsevier BV, 2017-10) Hubaud, Alexis; Regev, Ido; Mahadevan, Lakshminarayanan; Pourquié, Olivier
    The periodic segmentation of the vertebrate body axis into somites, and later vertebrae, relies on a genetic oscillator (the segmentation clock) driving the rhythmic activity of signaling pathways in the presomitic mesoderm (PSM). To understand whether oscillations are an intrinsic property of individual cells or represent a population-level phenomenon, we established culture conditions for stable oscillations at the cellular level. This system was used to demonstrate that oscillations are a collective property of PSM cells that can be actively triggered by a dynamical quorum sensing signal involving Yap and Notch signaling. Manipulation of Yap-dependent mechanical cues is sufficient to predictably switch isolated PSM cells from a quiescent to an oscillatory state , a behavior reminiscent of excitability in other systems. Together, our work argues that the segmentation clock behaves as an excitable system, introducing a broader paradigm to study such dynamics in vertebrate morphogenesis. YAP and Notch collaborate to control collective cellular oscillations during somitogenesis.
  • Thumbnail Image
    Publication
    Reversibility and criticality in amorphous solids
    (Nature Pub. Group, 2015) Regev, Ido; Weber, John; Reichhardt, Charles; Dahmen, Karin A.; Lookman, Turab
    The physical processes governing the onset of yield, where a material changes its shape permanently under external deformation, are not yet understood for amorphous solids that are intrinsically disordered. Here, using molecular dynamics simulations and mean-field theory, we show that at a critical strain amplitude the sizes of clusters of atoms undergoing cooperative rearrangements of displacements (avalanches) diverges. We compare this non-equilibrium critical behaviour to the prevailing concept of a ‘front depinning' transition that has been used to describe steady-state avalanche behaviour in different materials. We explain why a depinning-like process can result in a transition from periodic to chaotic behaviour and why chaotic motion is not possible in pinned systems. These findings suggest that, at least for highly jammed amorphous systems, the irreversibility transition may be a side effect of depinning that occurs in systems where the disorder is not quenched.