Person:
Sheng, Hao

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Sheng

First Name

Hao

Name

Sheng, Hao
Author's Publications: search.filters.isAuthorOfPublication.0530b3b8-428f-4d3c-8cee-8ae8fa56db1c

Search Results

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Publication
    Cyborg Organoids: Implantation of Nanoelectronics via Organogenesis for Tissue-Wide Electrophysiology
    (American Chemical Society (ACS), 2019-07-26) Li, Qiang; Nan, Kewang; Le Floch, Paul; Lin, Zuwan; Sheng, Hao; Blum, Thomas S.; Liu, Jia; Blum, Thomas
    Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies. Issues arise, however, from the invasive, localized implantation of electronics that destroys well-connected cellular networks within matured organs. Here, we report the creation of cyborg organoids: the three-dimensional (3D) assembly of soft, stretchable mesh nanoelectronics across the entire organoid by the cell–cell attraction forces from 2D-to-3D tissue reconfiguration during organogenesis. We demonstrate that stretchable mesh nanoelectronics can migrate with and grow into the initial 2D cell layers to form the 3D organoid structure with minimal impact on tissue growth and differentiation. The intimate contact between the dispersed nanoelectronics and cells enables us to chronically and systematically observe the evolution, propagation, and synchronization of the bursting dynamics in human cardiac organoids through their entire organogenesis.