Person: Ouyang, Jing
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Ouyang
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Jing
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Ouyang, Jing
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Publication A Peripheral Immune Signature of Responsiveness to PD-1 Blockade in Patients With Classical Hodgkin Lymphoma(Springer Science and Business Media LLC, 2020-08-10) Cader, Fathima Zumla; Hu, Xihao; Goh, Walter L.; Wienand, Kirsty; Ouyang, Jing; Mandato, Elisa; Redd, Robert; Lawton, Lee; Chen, Pei-Hsuan; Weirather, Jason L.; Schackmann, Ron C. J.; Li, Bo; Ma, Wenjiang; Armand, Philippe; Rodig, Scott; Neuberg, Donna; Liu, X. Shirley; Shipp, Margaret A.; shippPD-1 blockade is highly effective in classical Hodgkin lymphoma although the mechanism of action in this largely MHC class I-negative tumor remains undefined. Given this conundrum, we utilized the complementary approaches of T-cell receptor (TCR) sequencing and cytometry by time-of-flight analysis to obtain a peripheral immune signature of responsiveness to PD-1 blockade in clinical trial patients. Increased total and CD4+ TCR repertoire diversity and clonal expansion of singleton T cells were associated with response to anti PD-1 therapy. Additionally, responding patients had an increased abundance of activated NK cells and a newly identified CD3-CD68+CD4+GrB+ subset suggesting a complementary role for innate immunity in the efficacy of PD-1 blockade.