Person: Wu, Winona
Loading...
Email Address
AA Acceptance Date
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
Wu
First Name
Winona
Name
Wu, Winona
7 results
Search Results
Now showing 1 - 7 of 7
Publication Assessment of Functional Rhinoplasty with Spreader Grafting Using Acoustic Rhinomanometry and Validated Outcome Measurements(Wolters Kluwer Health, 2018) Paul, Marek; Kamali-Sadeghian, Parisa; Chen, Austin D.; Ibrahim, Ahmed M. S.; Wu, Winona; Becherer, Babette E.; Medin, Caroline; Lin, SamuelBackground: Rhinoplasty is 1 of the most common aesthetic and reconstructive plastic surgical procedures performed within the United States. Yet, data on functional reconstructive open and closed rhinoplasty procedures with or without spreader graft placement are not definitive as only a few studies have examined both validated measurable objective and subjective outcomes of spreader grafting during rhinoplasty. The aim of this study was to utilize previously validated measures to assess objective, functional outcomes in patients who underwent open and closed rhinoplasty with spreader grafting. Methods: We performed a retrospective review of consecutive rhinoplasty patients. Patients with internal nasal valve insufficiency who underwent an open and closed approach rhinoplasty between 2007 and 2016 were studied. The Cottle test and Nasal Obstruction Symptom Evaluation survey was used to assess nasal obstruction. Patient-reported symptoms were recorded. Acoustic rhinometry was performed pre- and postoperatively. Average minimal cross-sectional area of the nose was measured. Results: One hundred seventy-eight patients were reviewed over a period of 8 years. Thirty-eight patients were included in this study. Of those, 30 patients underwent closed rhinoplasty and 8 open rhinoplasty. Mean age was 36.9 ± 18.4 years. The average cross-sectional area in closed and open rhinoplasty patients increased significantly (P = 0.019). There was a functional improvement in all presented cases using the Nasal Obstruction Symptom Evaluation scale evaluation. Conclusions: Closed rhinoplasty with spreader grafting may play a significant role in the treatment of nasal valve collapse. A closed approach rhinoplasty including spreader grafting is a viable option in select cases with objective and validated functional improvement.Publication Abstract: Syndactyly: National Analysis of Trends in Epidemiology and Surgical Management from 1997–2012(Wolters Kluwer Health, 2017) Bucknor, Alexandra; Wu, Winona; Huang, Anne; Chattha, Anmol S.; Chen, Austin D.; Afshar, Salim; Lin, SamuelPublication Abstract: Crowdsourcing the Natural Breast in Ethnically-Diverse Women: Population Preferences(Wolters Kluwer Health, 2017) Bucknor, Alexandra; Chen, Austin D.; Kamali-Sadeghian, Parisa; Chattha, Anmol S.; van Veldhuisen, Charlotte; Branford, Olivier Alexandre; Chi, David; Wu, Winona; Lee, Bernard; Lin, SamuelPublication Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications(Frontiers Media S.A., 2016) Bi, Wenya; Zhang, Michael; Wu, Winona; Mei, Yu; Dunn, IanThere has been a recent revolution in our understanding of the genetic factors that drive meningioma, punctuating an equilibrium that has existed since Cushing’s germinal studies nearly a century ago. A growing appreciation that meningiomas share similar biologic features with other malignancies has allowed extrapolation of management strategies and lessons from intra-axial central nervous system neoplasms and systemic cancers to meningiomas. These features include a natural proclivity for invasion, frequent intratumoral heterogeneity, and correlation between biologic profile and clinical behavior. Next-generation sequencing has characterized recurrent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA, which are collectively present in ~80% of sporadic meningiomas. Genomic features of meningioma further associate with tumor location, histologic subtype, and possibly clinical behavior. Such genomic decryption, along with advances in targeted pharmacotherapy, provides a maturing integrated view of meningiomas. We review recent advances in meningioma genomics and probe their potential applications in diagnostic, therapeutic, and prognostic frontiers.Publication Management of intracranial melanomas in the era of precision medicine(Impact Journals LLC, 2017) Young, Grace; Bi, Wenya; Wu, Winona; Johanns, Tanner M.; Dunn, Gavin P.; Dunn, IanMelanoma is the most lethal of skin cancers, in part because of its proclivity for rapid and distant metastasis. It is also potentially the most neurotropic cancer in terms of probability of CNS metastasis from the primary lesion. Despite surgical resection and radiotherapy, prognosis remains guarded for patients with brain metastases. Over the past five years, a new domain of personalized therapy has emerged for advanced melanoma patients with the introduction of BRAF and other MAP kinase pathway inhibitors, immunotherapy, and combinatory therapeutic strategies. By targeting critical cellular signaling pathways and unleashing the adaptive immune response against tumor antigens, a subset of melanoma patients have demonstrated remarkable responses to these treatments. Over time, acquired resistance to these modalities inexorably develops, providing new challenges to overcome. We review the rapidly evolving terrain for intracranial melanoma treatment, address likely and potential mechanisms of resistance, as well as evaluate promising future therapeutic approaches currently under clinical investigation.Publication Radiographic prediction of meningioma grade by semantic and radiomic features(Public Library of Science, 2017) Coroller, Thibaud; Bi, Wenya; Huynh, Elizabeth; Abedalthagafi, Malak; Aizer, Ayal A.; Greenwald, Noah; Parmar, Chintan; Narayan, Vivek; Wu, Winona; Miranda de Moura, Samuel; Gupta, Saksham; Beroukhim, Rameen; Wen, Patrick Y.; Al-Mefty, Ossama; Dunn, Ian; Santagata, Sandro; Alexander, Brian; Huang, Raymond; Aerts, HugoObjectives: The clinical management of meningioma is guided by tumor grade and biological behavior. Currently, the assessment of tumor grade follows surgical resection and histopathologic review. Reliable techniques for pre-operative determination of tumor grade may enhance clinical decision-making. Methods: A total of 175 meningioma patients (103 low-grade and 72 high-grade) with pre-operative contrast-enhanced T1-MRI were included. Fifteen radiomic (quantitative) and 10 semantic (qualitative) features were applied to quantify the imaging phenotype. Area under the curve (AUC) and odd ratios (OR) were computed with multiple-hypothesis correction. Random-forest classifiers were developed and validated on an independent dataset (n = 44). Results: Twelve radiographic features (eight radiomic and four semantic) were significantly associated with meningioma grade. High-grade tumors exhibited necrosis/hemorrhage (ORsem = 6.6, AUCrad = 0.62–0.68), intratumoral heterogeneity (ORsem = 7.9, AUCrad = 0.65), non-spherical shape (AUCrad = 0.61), and larger volumes (AUCrad = 0.69) compared to low-grade tumors. Radiomic and sematic classifiers could significantly predict meningioma grade (AUCsem = 0.76 and AUCrad = 0.78). Furthermore, combining them increased the classification power (AUCradio = 0.86). Clinical variables alone did not effectively predict tumor grade (AUCclin = 0.65) or show complementary value with imaging data (AUCcomb = 0.84). Conclusions: We found a strong association between imaging features of meningioma and histopathologic grade, with ready application to clinical management. Combining qualitative and quantitative radiographic features significantly improved classification power.Publication Abstract 7. Prospective, Double-Blind Evaluation of Umbilical Reconstruction of Techniques Using Conventional and Crowdsourcing Methods(Wolters Kluwer Health, 2017) van Veldhuisen, Charlotte L.; Kamali-Sadeghian, Parisa; Wu, Winona; Becherer, Babette E.; Sinno, Hani H.; Ashraf, Azra A.; Ibrahim, Ahmed M.S.; Tobias, Adam; Lee, Bernard; Lin, Samuel