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Uygur, Aysu

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Uygur

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Aysu

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Uygur, Aysu
Author's Publications: search.filters.isAuthorOfPublication.136244ac-06fb-43b5-8ce4-47339c66e563

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    Evolution of Morphology: Modifications to Size and Pattern
    (2014-06-06) Uygur, Aysu; Tabin, Clifford James; Cepko, Constance; Salic, Adrian; Abzhanov, Arkhat; Levin, Michael
    A remarkable property of developing organisms is the consistency and robustness within the formation of the body plan. In many animals, morphological pattern formation is orchestrated by conserved signaling pathways, through a process of strict spatio-temporal regulation of cell fate specification. Although morphological patterns have been the focus of both classical and recent studies, little is known about how this robust process is modified throughout evolution to accomodate different morphological adaptations.
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    Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube
    (2016) Uygur, Aysu; Young, John; Huycke, Tyler; Koska, Mervenaz; Briscoe, James; Tabin, Clifford
    SUMMARY Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly understood. We have examined this phenomenon in the context of the patterning of the ventral neural tube in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two species that differ in size during the time of neural tube patterning. We find that scaling is achieved, at least in part, by altering the sensitivity of the target cells to SHH and appears to be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GLI2 and GLI3. This mechanism contrasts with previous experimental and theoretical analyses of morphogenic scaling that have focused on compensatory changes in the morphogen gradient itself.