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Yedid, Moran

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Yedid, Moran
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    Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
    (Springer Nature, 2016) Lind, Johan; Busbee, Travis Alexander; Valentine, Alexander; Pasqualini, Francesco; Yuan, Hongyan; Yedid, Moran; Park, Sung-Jin; Kotikian, Arda; Nesmith, Alexander Peyton; Campbell, Patrick H.; Vlassak, Joost; Lewis, Jennifer; Parker, Kevin
    Biomedical research has relied on animal studies and conventional cell cultures for decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that recapitulate the structure and function of native tissues in vitro, have emerged as a promising alternative1. However, current MPS typically lack integrated sensors and their fabrication requires multi-step lithographic processes2. Here, we introduce a facile route for fabricating a new class of instrumented cardiac microphysiological devices via multimaterial three-dimensional (3D) printing. Specifically, we designed six functional inks, based on piezo-resistive, high-conductance, and biocompatible soft materials that enable integration of soft strain gauge sensors within micro-architectures that guide the self-assembly of physio-mimetic laminar cardiac tissues. We validated that these embedded sensors provide non-invasive, electronic readouts of tissue contractile stresses inside cell incubator environments. We further applied these devices to study drug responses, as well as the contractile development of human stem cell-derived laminar cardiac tissues over four weeks.