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Mitchel, Jennifer

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Mitchel

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Jennifer

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Mitchel, Jennifer

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Author's Publications: search.filters.isAuthorOfPublication.1e769d8d-3b7c-4e7a-8f22-2016317091ff

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    Geometric constraints during epithelial jamming
    (Springer Science and Business Media LLC, 2018-04-02) Atia, Lior; Bi, Dapeng; Sharma, Yasha; Mitchel, Jennifer; Gweon, Bomi; Koehler, Stephan; DeCamp, Stephen; Lan, Bo; Kim, Jae Hun; Hirsch, Rebecca; Pegoraro, Adrian; Lee, Kyu Ha; Starr, Jacqueline; Weitz, David; Martin, Adam; Park, Jin-Ah; Butler, James; Fredberg, Jeffrey
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    Unjamming and cell shape in the asthmatic airway epithelium
    (Nature Publishing Group, 2015) Park, Jin-Ah; Kim, Jae Hun; Bi, Dapeng; Mitchel, Jennifer; Qazvini, Nader Taheri; Tantisira, Kelan; Park, Chan Young; McGill, Maureen; Kim, Sae-Hoon; Gweon, Bomi; Notbohm, Jacob; Steward Jr, Robert; Burger, Stephanie; Randell, Scott H.; Kho, Alvin; Tambe, Dhananjay; Hardin, Corey; Shore, Stephanie; Israel, Elliot; Weitz, David; Tschumperlin, Daniel J.; Henske, Elizabeth; Weiss, Scott; Manning, Mary; Butler, James; Drazen, Jeffrey; Fredberg, Jeffrey
    From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems— both inert and living—have the potential to jam. The collective can sometimes flow like a fluid or jam and rigidify like a solid. The unjammed-to-jammed transition remains poorly understood, however, and structural properties characterizing these phases remain unknown. Using primary human bronchial epithelial cells, we show that the jamming transition in asthma is linked to cell shape, thus establishing in that system a structural criterion for cell jamming. Surprisingly, the collapse of critical scaling predicts a counter-intuitive relationship between jamming, cell shape and cell–cell adhesive stresses that is borne out by direct experimental observations. Cell shape thus provides a rigorous structural signature for classification and investigation of bronchial epithelial layer jamming in asthma, and potentially in any process in disease or development in which epithelial dynamics play a prominent role.