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Scarcelli, Giuliano

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Scarcelli

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Giuliano

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Scarcelli, Giuliano
Author's Publications: search.filters.isAuthorOfPublication.21541589-aeac-4768-9b63-975d4007e0dc

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Now showing 1 - 3 of 3
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    Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties
    (The Royal Society, 2014) Kling, Sabine; Akca, Imran B.; Chang, Ernest W.; Scarcelli, Giuliano; Bekesi, Nandor; Yun, Seok-Hyun; Marcos, Susana
    Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of the frequency response function on: corneal elasticity, viscoelasticity, geometry (thickness and curvature), IOP and density. The model was verified experimentally in flaps from three bovine corneas and in two enucleated porcine eyes using sound excitation (100–110 dB) together with a phase-sensitive OCT to measure the frequency response function (range 50–510 Hz). Simulations showed that corneal vibration in flaps is sensitive to both, geometrical and biomechanical parameters, whereas in whole globes it is primarily sensitive to corneal biomechanical parameters only. Calculations based on the natural frequency shift revealed that flaps of the posterior cornea were 0.8 times less stiff than flaps from the anterior cornea and cross-linked corneas were 1.6 times stiffer than virgin corneas. Sensitivity analysis showed that natural vibration frequencies of whole globes were nearly independent from corneal thickness and IOP within the physiological range. OCT vibrography is a promising non-invasive technique to measure corneal elasticity without biases from corneal thickness and IOP.
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    Multistage VIPA etalons for high-extinction parallel Brillouin spectroscopy
    (Optical Society of America, 2011) Scarcelli, Giuliano; Yun, Seok-Hyun
    We demonstrate a high-resolution high-extinction parallel spectrometer for Brillouin spectroscopy of turbid samples. Cascading multiple VIPA etalons in the cross-axis configuration allowed us to achieve a high extinction ratio of up to 80 dB with sub-GHz resolution. Using a three-stage VIPA, we obtained the Brillouin spectra from Intralipid solutions at concentrations up to 10%.
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    In vivo Brillouin optical microscopy of the human eye
    (Optical Society of America, 2012) Scarcelli, Giuliano; Yun, Seok-Hyun
    We report the first Brillouin measurement of the human eye in vivo. We constructed a Brillouin optical scanner safe for human use by employing continuous-wave laser light at 780 nm at a low power of 0.7 mW. With a single scan along the optic axis of the eye, the axial profile of Brillouin frequency shift was obtained with a pixel acquisition time of 0.4 s and axial resolution of about 60 μm, showing the depth-dependent biomechanical properties in the cornea and lens.