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Choueiri, Toni

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Choueiri

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Toni

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Choueiri, Toni
Author's Publications: search.filters.isAuthorOfPublication.250b937b-5bca-4920-8fe5-cc171d9c2b5e

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    Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study
    (BioMed Central, 2015) Fay, André P; Signoretti, Sabina; Callea, Marcella; Telό, Gabriela H; McKay, Rana R; Song, Jiaxi; Carvo, Ingrid; Lampron, Megan E; Kaymakcalan, Marina D; Poli-de-Figueiredo, Carlos E; Bellmunt, Joaquim; Hodi, F Stephen; Freeman, Gordon; Elfiky, Aymen; Choueiri, Toni
    Background: Adrenocortical carcinoma (ACC) is a rare tumor in which prognostic factors are still not well established. Programmed Death Ligand-1 (PD-L1) expression in ACC and its association with clinico-pathological features and survival outcomes are unknown. Methods: Formalin-fixed paraffin-embedded (FFPE) specimens were obtained from 28 patients with ACC. PD-L1 expression was evaluated by immunohistochemistry (IHC) in both tumor cell membrane and tumor infiltrating mononuclear cells (TIMC). PD-L1 positivity on tumor cells was defined as ≥5% tumor cell membrane staining. TIMC were evaluated by IHC using a CD45 monoclonal antibody. For PD-L1 expression in TIMC, a combined score based on the extent of infiltrates and percentage of positive cells was developed. Any score greater that zero was considered PD-L1 positive. Baseline clinico-pathological characteristics and follow up data were retrospectively collected. Comparisons between PD-L1 expression and clinico-pathological features were evaluated using unpaired t-test and Fisher’s exact test. Kaplan-Meier method and log-rank test were used to assess association between PD-L1 expression and 5-year overall survival (OS). Results: Among 28 patients with surgically treated ACC, 3 (10.7%) were considered PD-L1 positive on tumor cell membrane. On the other hand, PD-L1 expression in TIMC was performed in 27 specimens and PD-L1 positive staining was observed in 19 (70.4%) patients. PD-L1 positivity in either tumor cell membrane or TIMC was not significantly associated with higher stage at diagnosis, higher tumor grade, excessive hormone secretion, or OS. Conclusions: PD-L1 expression can exist in ACC in both tumor cell membrane and TIMC with no relationship to clinico-pathologic parameters or survival. Electronic supplementary material The online version of this article (doi:10.1186/s40425-015-0047-3) contains supplementary material, which is available to authorized users.
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    Response to single agent PD-1 inhibitor after progression on previous PD-1/PD-L1 inhibitors: a case series
    (BioMed Central, 2017) Martini, Dylan J.; Lalani, Aly-Khan A.; Bossé, Dominick; Steinharter, John A.; Harshman, Lauren; Hodi, F. Stephen; Ott, Patrick; Choueiri, Toni
    Background: Monoclonal antibodies targeting the PD-1/PD-L1 axis have gained increasing attention across many solid tumors and hematologic malignancies due to their efficacy and favorable toxicity profile. With more than 1 agent now FDA-approved in a wide variety of tumor types, and with others in clinical trials, it is becoming more common that patients present to clinic for potential treatment with a second PD-1/PD-L1 inhibitor. Case presentation: In this report, we present two patients with renal cell carcinoma and one with melanoma who received PD-1/PD-L1 inhibitors. Upon progression on their first-line PD-1/PD-L1 inhibitors, these patients received a different PD-1 inhibitor (nivolumab in all cases) and all had progressive disease as their best response to the subsequent PD-1 inhibitor. The reported clinical information focuses on the course of the disease and the responses to all treatment regimens. Conclusions: Clinicians should refrain from using multiple PD-1/PD-L1 inhibitors sequentially outside of clinical trials until there is sufficient data to support this practice routinely. Prospective studies that allow prior treatment with PD-1/PD-L1 are needed to validate the efficacy and safety of these drugs in the second line or later setting. Furthermore, ongoing efforts that aim to identify mechanisms of resistance to immunotherapy will be informative and may ultimately assist physicians in select the optimal treatment following progression on PD-1/PD-L1 inhibitor.
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    Disparities in selective referral for cancer surgeries: implications for the current healthcare delivery system
    (BMJ Publishing Group, 2014) Sun, Maxine; Karakiewicz, Pierre I; Sammon, Jesse D; Sukumar, Shyam; Gervais, Mai-Kim; Nguyen, Paul; Choueiri, Toni; Menon, Mani; Trinh, Quoc-Dien
    Objectives: Among considerable efforts to improve quality of surgical care, expedited measures such as a selective referral to high-volume institutions have been advocated. Our objective was to examine whether racial, insurance and/or socioeconomic disparities exist in the use of high-volume hospitals for complex surgical oncological procedures within the USA. Design, setting and participants Patients undergoing colectomy, cystectomy, oesophagectomy, gastrectomy, hysterectomy, lung resection, pancreatectomy or prostatectomy were identified retrospectively, using the Nationwide Inpatient Sample, between years 1999 and 2009. This resulted in a weighted estimate of 2 508 916 patients. Primary outcome measures Distribution of patients according to race, insurance and income characteristics was examined according to low-volume and high-volume hospitals (highest 20% of patients according to the procedure-specific mean annual volume). Generalised linear regression models for prediction of access to high-volume hospitals were performed. Results: Insurance providers and county income levels varied differently according to patients’ race. Most Caucasians resided in wealthier counties, regardless of insurance types (private/Medicare), while most African Americans resided in less wealthy counties (≤$24 999), despite being privately insured. In general, Caucasians, privately insured, and those residing in wealthier counties (≥$45 000) were more likely to receive surgery at high-volume hospitals, even after adjustment for all other patient-specific characteristics. Depending on the procedure, some disparities were more prominent, but the overall trend suggests a collinear effect for race, insurance type and county income levels. Conclusions: Prevailing disparities exist according to several patient and sociodemographic characteristics for utilisation of high-volume hospitals. Efforts should be made to directly reduce such disparities and ensure equal healthcare delivery.
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    Genomic investigation of etiologic heterogeneity: methodologic challenges
    (BioMed Central, 2014) Begg, Colin B; Seshan, Venkatraman E; Zabor, Emily C; Furberg, Helena; Arora, Arshi; Shen, Ronglai; Maranchie, Jodi K; Nielsen, Matthew E; Rathmell, W Kimryn; Signoretti, Sabina; Tamboli, Pheroze; Karam, Jose A; Choueiri, Toni; Hakimi, A Ari; Hsieh, James J
    Background: The etiologic heterogeneity of cancer has traditionally been investigated by comparing risk factor frequencies within candidate sub-types, defined for example by histology or by distinct tumor markers of interest. Increasingly tumors are being profiled for molecular features much more extensively. This greatly expands the opportunities for defining distinct sub-types. In this article we describe an exploratory analysis of the etiologic heterogeneity of clear cell kidney cancer. Data are available on the primary known risk factors for kidney cancer, while the tumors are characterized on a genome-wide basis using expression, methylation, copy number and mutational profiles. Methods: We use a novel clustering strategy to identify sub-types. This is accomplished independently for the expression, methylation and copy number profiles. The goals are to identify tumor sub-types that are etiologically distinct, to identify the risk factors that define specific sub-types, and to endeavor to characterize the key genes that appear to represent the principal features of the distinct sub-types. Results: The analysis reveals strong evidence that gender represents an important factor that distinguishes disease sub-types. The sub-types defined using expression data and methylation data demonstrate considerable congruence and are also clearly correlated with mutations in important cancer genes. These sub-types are also strongly correlated with survival. The complexity of the data presents many analytical challenges including, prominently, the risk of false discovery. Conclusions: Genomic profiling of tumors offers the opportunity to identify etiologically distinct sub-types, paving the way for a more refined understanding of cancer etiology. Electronic supplementary material The online version of this article (doi:10.1186/1471-2288-14-138) contains supplementary material, which is available to authorized users.
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    Identification of ALK Gene Alterations in Urothelial Carcinoma
    (Public Library of Science, 2014) Bellmunt, Joaquim; Selvarajah, Shamini; Rodig, Scott; Salido, Marta; de Muga, Silvia; Costa, Irmgard; Bellosillo, Beatriz; Werner, Lillian; Mullane, Stephanie; Fay, André P.; O'Brien, Robert; Barretina, Jordi; Minoche, André E.; Signoretti, Sabina; Montagut, Clara; Himmelbauer, Heinz; Berman, David M.; Kantoff, Philip; Choueiri, Toni; Rosenberg, Jonathan E.
    Background: Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers. Currently, there is no information about ALK gene alterations in urothelial carcinoma (UC) and its correlation with clinical or pathologic features and outcome. Methods: Samples from patients with advanced UC and correlative clinical data were collected. Genomic imbalances were investigated by array comparative genomic hybridization (aCGH). ALK gene status was evaluated by fluorescence in situ hybridization (FISH). ALK expression was assessed by immunohistochemistry (IHC) and high-throughput mutation analysis with Oncomap 3 platform. Next generation sequencing was performed using Illumina Genome Analyzer IIx, and Illumina HiSeq 2000 in the FISH positive case. Results: 70 of 96 patients had tissue available for all the tests performed. Arm level copy number gains at chromosome 2 were identified in 17 (24%) patients. Minor copy number alterations (CNAs) in the proximity of ALK locus were found in 3 patients by aCGH. By FISH analysis, one of these samples had a deletion of the 5′ALK. Whole genome next generation sequencing was inconclusive to confirm the deletion at the level of the ALK gene at the coverage level used. We did not observe an association between ALK CNA and overall survival, ECOG PS, or development of visceral disease. Conclusions: ALK genomic alterations are rare and probably without prognostic implications in UC. The potential for testing ALK inhibitors in UC merits further investigation but might be restricted to the identification of an enriched population.
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    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016
    (BioMed Central, 2016) Lundqvist, Andreas; van Hoef, Vincent; Zhang, Xiaonan; Wennerberg, Erik; Lorent, Julie; Witt, Kristina; Sanz, Laia Masvidal; Liang, Shuo; Murray, Shannon; Larsson, Ola; Kiessling, Rolf; Mao, Yumeng; Sidhom, John-William; Bessell, Catherine A.; Havel, Jonathan; Schneck, Jonathan; Chan, Timothy A.; Sachsenmeier, Eliot; Woods, David; Berglund, Anders; Ramakrishnan, Rupal; Sodre, Andressa; Weber, Jeffrey; Zappasodi, Roberta; Li, Yanyun; Qi, Jingjing; Wong, Philip; Sirard, Cynthia; Postow, Michael; Newman, Walter; Koon, Henry; Velcheti, Vamsidhar; Callahan, Margaret K.; Wolchok, Jedd D.; Merghoub, Taha; Lum, Lawrence G.; Choi, Minsig; Thakur, Archana; Deol, Abhinav; Dyson, Gregory; Shields, Anthony; Haymaker, Cara; Uemura, Marc; Murthy, Ravi; James, Marihella; Wang, Daqing; Brevard, Julie; Monaghan, Catherine; Swann, Suzanne; Geib, James; Cornfeld, Mark; Chunduru, Srinivas; Agrawal, Sudhir; Yee, Cassian; Wargo, Jennifer; Patel, Sapna P.; Amaria, Rodabe; Tawbi, Hussein; Glitza, Isabella; Woodman, Scott; Hwu, Wen-Jen; Davies, Michael A.; Hwu, Patrick; Overwijk, Willem W.; Bernatchez, Chantale; Diab, Adi; Massarelli, Erminia; Segal, Neil H.; Ribrag, Vincent; Melero, Ignacio; Gangadhar, Tara C.; Urba, Walter; Schadendorf, Dirk; Ferris, Robert L.; Houot, Roch; Morschhauser, Franck; Logan, Theodore; Luke, Jason J.; Sharfman, William; Barlesi, Fabrice; Ott, Patrick A.; Mansi, Laura; Kummar, Shivaani; Salles, Gilles; Carpio, Cecilia; Meier, Roland; Krishnan, Suba; McDonald, Dan; Maurer, Matthew; Gu, Xuemin; Neely, Jaclyn; Suryawanshi, Satyendra; Levy, Ronald; Khushalani, Nikhil; Wu, Jennifer; Zhang, Jinyu; Basher, Fahmin; Rubinstein, Mark; Bucsek, Mark; Qiao, Guanxi; MacDonald, Cameron; Hylander, Bonnie; Repasky, Elizabeth; Chatterjee, Shilpak; Daenthanasanmak, Anusara; Chakraborty, Paramita; Toth, Kyle; Meek, Megan; Garrett-Mayer, Elizabeth; Nishimura, Michael; Paulos, Chrystal; Beeson, Craig; Yu, Xuezhong; Mehrotra, Shikhar; Zhao, Fei; Evans, Kathy; Xiao, Christine; Holtzhausen, Alisha; Hanks, Brent A.; Scharping, Nicole; Menk, Ashley V.; Moreci, Rebecca; Whetstone, Ryan; Dadey, Rebekah; Watkins, Simon; Ferris, Robert; Delgoffe, Greg M.; Peled, Jonathan; Devlin, Sean; Staffas, Anna; Lumish, Melissa; Rodriguez, Kori Porosnicu; Ahr, Katya; Perales, Miguel; Giralt, Sergio; Taur, Ying; Pamer, Eric; van den Brink, Marcel R. M.; Jenq, Robert; Annels, Nicola; Pandha, Hardev; Simpson, Guy; Mostafid, Hugh; Harrington, Kevin; Melcher, Alan; Grose, Mark; Davies, Bronwyn; Au, Gough; Karpathy, Roberta; Shafren, Darren; Ricca, Jacob; Zamarin, Dmitriy; Batista, Luciana; Marliot, Florence; Vasaturo, Angela; Carpentier, Sabrina; Poggionovo, Cécile; Frayssinet, Véronique; Fieschi, Jacques; Van den Eynde, Marc; Pagès, Franck; Galon, Jérôme; Hermitte, Fabienne; Smith, Sean G.; Nguyen, Khue; Ravindranathan, Sruthi; Koppolu, Bhanu; Zaharoff, David; Schvartsman, Gustavo; Bassett, Roland; McQuade, Jennifer L.; Haydu, Lauren E.; Kline, Douglas; Chen, Xiufen; Fosco, Dominick; Kline, Justin; Overacre, Abigail; Chikina, Maria; Brunazzi, Erin; Shayan, Gulidanna; Horne, William; Kolls, Jay; Bruno, Tullia C.; Workman, Creg; Vignali, Dario; Adusumilli, Prasad S.; Ansa-Addo, Ephraim A; Li, Zihai; Gerry, Andrew; Sanderson, Joseph P.; Howe, Karen; Docta, Roslin; Gao, Qian; Bagg, Eleanor A. L.; Tribble, Nicholas; Maroto, Miguel; Betts, Gareth; Bath, Natalie; Melchiori, Luca; Lowther, Daniel E.; Ramachandran, Indu; Kari, Gabor; Basu, Samik; Binder-Scholl, Gwendolyn; Chagin, Karen; Pandite, Lini; Holdich, Tom; Amado, Rafael; Zhang, Hua; Glod, John; Bernstein, Donna; Jakobsen, Bent; Mackall, Crystal; Wong, Ryan; Silk, Jonathan D.; Adams, Katherine; Hamilton, Garth; Bennett, Alan D.; Brett, Sara; Jing, Junping; Quattrini, Adriano; Saini, Manoj; Wiedermann, Guy; Brewer, Joanna; Duong, MyLinh; Lu, An; Chang, Peter; Mahendravada, Aruna; Shinners, Nicholas; Slawin, Kevin; Spencer, David M.; Foster, Aaron E.; Bayle, J. Henri; Bergamaschi, Cristina; Ng, Sinnie Sin Man; Nagy, Bethany; Jensen, Shawn; Hu, Xintao; Alicea, Candido; Fox, Bernard; Felber, Barbara; Pavlakis, George; Chacon, Jessica; Yamamoto, Tori; Garrabrant, Thomas; Cortina, Luis; Powell, Daniel J.; Donia, Marco; Kjeldsen, Julie Westerlin; Andersen, Rikke; Westergaard, Marie Christine Wulff; Bianchi, Valentina; Legut, Mateusz; Attaf, Meriem; Dolton, Garry; Szomolay, Barbara; Ott, Sascha; Lyngaa, Rikke; Hadrup, Sine Reker; Sewell, Andrew Kelvin; Svane, Inge Marie; Fan, Aaron; Kumai, Takumi; Celis, Esteban; Frank, Ian; Stramer, Amanda; Blaskovich, Michelle A.; Wardell, Seth; Fardis, Maria; Bender, James; Lotze, Michael T.; Goff, Stephanie L.; Zacharakis, Nikolaos; Assadipour, Yasmine; Prickett, Todd D.; Gartner, Jared J.; Somerville, Robert; Black, Mary; Xu, Hui; Chinnasamy, Harshini; Kriley, Isaac; Lu, Lily; Wunderlich, John; Robbins, Paul F.; Rosenberg, Steven; Feldman, Steven A.; Trebska-McGowan, Kasia; Malekzadeh, Parisa; Payabyab, Eden; Sherry, Richard; Gokuldass, Aishwarya; Kopits, Charlene; Rabinovich, Brian; Green, Daniel S.; Kamenyeva, Olena; Zoon, Kathryn C.; Annunziata, Christina M.; Hammill, Joanne; Helsen, Christopher; Aarts, Craig; Bramson, Jonathan; Harada, Yui; Yonemitsu, Yoshikazu; Mwawasi, Kenneth; Denisova, Galina; Giri, Rajanish; Jin, Benjamin; Campbell, Tracy; Draper, Lindsey M.; Stevanovic, Sanja; Yu, Zhiya; Weissbrich, Bianca; Restifo, Nicholas P.; Trimble, Cornelia L.; Hinrichs, Christian S.; Tsang, Kwong; Fantini, Massimo; Hodge, James W.; Fujii, Rika; Fernando, Ingrid; Jochems, Caroline; Heery, Christopher; Gulley, James; Soon-Shiong, Patrick; Schlom, Jeffrey; Jing, Weiqing; Gershan, Jill; Blitzer, Grace; Weber, James; McOlash, Laura; Johnson, Bryon D.; Kiany, Simin; Gangxiong, Huang; Kleinerman, Eugenie S.; Klichinsky, Michael; Ruella, Marco; Shestova, Olga; Kenderian, Saad; Kim, Miriam; Scholler, John; June, Carl H.; Gill, Saar; Moogk, Duane; Zhong, Shi; Liadi, Ivan; Rittase, William; Fang, Victoria; Dougherty, Janna; Perez-Garcia, Arianne; Osman, Iman; Zhu, Cheng; Varadarajan, Navin; Frey, Alan; Krogsgaard, Michelle; Landi, Daniel; Fousek, Kristen; Mukherjee, Malini; Shree, Ankita; Joseph, Sujith; Bielamowicz, Kevin; Byrd, Tiara; Ahmed, Nabil; Hegde, Meenakshi; Lee, Sylvia; Byrd, David; Thompson, John; Bhatia, Shailender; Tykodi, Scott; Delismon, Judy; Chu, Liz; Abdul-Alim, Siddiq; Ohanian, Arpy; DeVito, Anna Marie; Riddell, Stanley; Margolin, Kim; Magalhaes, Isabelle; Mattsson, Jonas; Uhlin, Michael; Nemoto, Satoshi; Villarroel, Patricio Pérez; Nakagawa, Ryosuke; Mule, James J.; Mailloux, Adam W.; Mata, Melinda; Nguyen, Phuong; Gerken, Claudia; DeRenzo, Christopher; Gottschalk, Stephen; Mathieu, Mélissa; Pelletier, Sandy; Stagg, John; Turcotte, Simon; Minutolo, Nicholas; Sharma, Prannda; Tsourkas, Andrew; Mockel-Tenbrinck, Nadine; Mauer, Daniela; Drechsel, Katharina; Barth, Carola; Freese, Katharina; Kolrep, Ulrike; Schult, Silke; Assenmacher, Mario; Kaiser, Andrew; Mullinax, John; Hall, MacLean; Le, Julie; Kodumudi, Krithika; Royster, Erica; Richards, Allison; Gonzalez, Ricardo; Sarnaik, Amod; Pilon-Thomas, Shari; Nielsen, Morten; Krarup-Hansen, Anders; Hovgaard, Dorrit; Petersen, Michael Mørk; Loya, Anand Chainsukh; Junker, Niels; Rivas, Charlotte; Parihar, Robin; Rooney, Cliona M.; Qin, Haiying; Nguyen, Sang; Su, Paul; Burk, Chad; Duncan, Brynn; Kim, Bong-Hyun; Kohler, M. Eric; Fry, Terry; Rao, Arjun A.; Teyssier, Noam; Pfeil, Jacob; Sgourakis, Nikolaos; Salama, Sofie; Haussler, David; Richman, Sarah A.; Nunez-Cruz, Selene; Gershenson, Zack; Mourelatos, Zissimos; Barrett, David; Grupp, Stephan; Milone, Michael; Rodriguez-Garcia, Alba; Robinson, Matthew K.; Adams, Gregory P.; Santos, João; Havunen, Riikka; Siurala, Mikko; Cervera-Carrascón, Víctor; Parviainen, Suvi; Antilla, Marjukka; Hemminki, Akseli; Sethuraman, Jyothi; Santiago, Laurelis; Chen, Jie Qing; Dai, Zhimin; Sha, Huizi; Su, Shu; Ding, Naiqing; Liu, Baorui; Pasetto, Anna; Helman, Sarah R.; Rosenberg, Steven A.; Burgess, Melissa; Zhang, Hui; Lee, Tien; Klingemann, Hans; Nghiem, Paul; Kirkwood, John M.; Rossi, John M.; Sherman, Marika; Xue, Allen; Shen, Yueh-wei; Navale, Lynn; Kochenderfer, James N.; Bot, Adrian; Veerapathran, Anandaraman; Wiener, Doris; Waller, Edmund K.; Li, Jian-Ming; Petersen, Christopher; Blazar, Bruce R.; Li, Jingxia; Giver, Cynthia R.; Wang, Ziming; Grossenbacher, Steven K.; Sturgill, Ian; Canter, Robert J.; Murphy, William J.; Zhang, Congcong; Burger, Michael C.; Jennewein, Lukas; Waldmann, Anja; Mittelbronn, Michel; Tonn, Torsten; Steinbach, Joachim P.; Wels, Winfried S.; Williams, Jason B.; Zha, Yuanyuan; Gajewski, Thomas F.; Williams, LaTerrica C.; Krenciute, Giedre; Kalra, Mamta; Louis, Chrystal; Xin, Gang; Schauder, David; Jiang, Aimin; Joshi, Nikhil; Cui, Weiguo; Zeng, Xue; Zhao, Zeguo; Hamieh, Mohamad; Eyquem, Justin; Gunset, Gertrude; Bander, Neil; Sadelain, Michel; Askmyr, David; Abolhalaj, Milad; Lundberg, Kristina; Greiff, Lennart; Lindstedt, Malin; Angell, Helen K.; Kim, Kyoung-Mee; Kim, Seung-Tae; Kim, Sung; Sharpe, Alan D.; Ogden, Julia; Davenport, Anna; Hodgson, Darren R.; Barrett, Carl; Lee, Jeeyun; Kilgour, Elaine; Hanson, Jodi; Caspell, Richard; Karulin, Alexey; Lehmann, Paul; Ansari, Tameem; Schiller, Annemarie; Sundararaman, Srividya; Roen, Diana; Ayers, Mark; Levitan, Diane; Arreaza, Gladys; Liu, Fang; Mogg, Robin; Bang, Yung-Jue; O’Neil, Bert; Cristescu, Razvan; Friedlander, Philip; Wassman, Karl; Kyi, Chrisann; Oh, William; Bhardwaj, Nina; Bornschlegl, Svetlana; Gustafson, Michael P.; Gastineau, Dennis A.; Parney, Ian F.; Dietz, Allan B.; Carvajal-Hausdorf, Daniel; Mani, Nikita; Schalper, Kurt; Rimm, David; Chang, Serena; Kurland, John; Ahlers, Christoph Matthias; Jure-Kunkel, Maria; Cohen, Lewis; Maecker, Holden; Kohrt, Holbrook; Chen, Shuming; Crabill, George; Pritchard, Theresa; McMiller, Tracee; Pardoll, Drew; Pan, Fan; Topalian, Suzanne; Danaher, Patrick; Warren, Sarah; Dennis, Lucas; White, Andrew M.; D’Amico, Leonard; Geller, Melissa; Disis, Mary L.; Beechem, Joseph; Odunsi, Kunle; Fling, Steven; Derakhshandeh, Roshanak; Webb, Tonya J.; Dubois, Sigrid; Conlon, Kevin; Bryant, Bonita; Hsu, Jennifer; Beltran, Nancy; Müller, Jürgen; Waldmann, Thomas; Duhen, Rebekka; Duhen, Thomas; Thompson, Lucas; Montler, Ryan; Weinberg, Andrew; Kates, Max; Early, Brandon; Yusko, Erik; Schreiber, Taylor H.; Bivalacqua, Trinity J.; Lunceford, Jared; Nebozhyn, Michael; Murphy, Erin; Loboda, Andrey; Kaufman, David R.; Albright, Andrew; Cheng, Jonathan; Kang, S. Peter; Shankaran, Veena; Piha-Paul, Sarina A.; Yearley, Jennifer; Seiwert, Tanguy; Ribas, Antoni; McClanahan, Terrill K.; Sher, Xinwei; Liu, Xiao Qiao; Joe, Andrew; Plimack, Elizabeth; Forrest-Hay, Alex; Guyre, Cheryl A.; Narumiya, Kohei; Delcommenne, Marc; Hirsch, Heather A.; Deshpande, Amit; Reeves, Jason; Shu, Jenny; Zi, Tong; Michaelson, Jennifer; Law, Debbie; Trehu, Elizabeth; Sathyanaryanan, Sriram; Hodkinson, Brendan P.; Hutnick, Natalie A.; Schaffer, Michael E.; Gormley, Michael; Hulett, Tyler; Ballesteros-Merino, Carmen; Dubay, Christopher; Afentoulis, Michael; Reddy, Ashok; David, Larry; Jayant, Kumar; Agrawal, Swati; Agrawal, Rajendra; Jeyakumar, Ghayathri; Kim, Seongho; Kim, Heejin; Silski, Cynthia; Suisham, Stacey; Heath, Elisabeth; Vaishampayan, Ulka; Vandeven, Natalie; Viller, Natasja Nielsen; O’Connor, Alison; Chen, Hui; Bossen, Bolette; Sievers, Eric; Uger, Robert; Johnson, Lisa; Kao, Hsiang-Fong; Hsiao, Chin-Fu; Lai, Shu-Chuan; Wang, Chun-Wei; Ko, Jenq-Yuh; Lou, Pei-Jen; Lee, Tsai-Jan; Liu, Tsang-Wu; Hong, Ruey-Long; Kearney, Staci J.; Black, Joshua C.; Landis, Benjamin J.; Koegler, Sally; Hirsch, Brooke; Gianani, Roberto; Kim, Jeffrey; He, Ming-Xiao; Zhang, Bingqing; Su, Nan; Luo, Yuling; Ma, Xiao-Jun; Park, Emily; Kim, Dae Won; Copploa, Domenico; Kothari, Nishi; doo Chang, Young; Kim, Richard; Kim, Namyong; Lye, Melvin; Wan, Ee; Knaus, Hanna A.; Berglund, Sofia; Hackl, Hubert; Karp, Judith E.; Gojo, Ivana; Luznik, Leo; Hong, Henoch S.; Koch, Sven D.; Scheel, Birgit; Gnad-Vogt, Ulrike; Kallen, Karl-Josef; Wiegand, Volker; Backert, Linus; Kohlbacher, Oliver; Hoerr, Ingmar; Fotin-Mleczek, Mariola; Billingsley, James M.; Koguchi, Yoshinobu; Conrad, Valerie; Miller, William; Gonzalez, Iliana; Poplonski, Tomasz; Meeuwsen, Tanisha; Howells-Ferreira, Ana; Rattray, Rogan; Campbell, Mary; Bifulco, Carlo; Bahjat, Keith; Curti, Brendan; Vetsika, E-K; Kallergi, G.; Aggouraki, Despoina; Lyristi, Z.; Katsarlinos, P.; Koinis, Filippos; Georgoulias, V.; Kotsakis, Athanasios; Martin, Nathan T.; Aeffner, Famke; Cerkovnik, Logan; Pratte, Luke; Kim, Rebecca; Krueger, Joseph; Martínez-Usatorre, Amaia; Jandus, Camilla; Donda, Alena; Carretero-Iglesia, Laura; Speiser, Daniel E.; Zehn, Dietmar; Rufer, Nathalie; Romero, Pedro; Panda, Anshuman; Mehnert, Janice; Hirshfield, Kim M.; Riedlinger, Greg; Damare, Sherri; Saunders, Tracie; Sokol, Levi; Stein, Mark; Poplin, Elizabeth; Rodriguez-Rodriguez, Lorna; Silk, Ann; Chan, Nancy; Frankel, Melissa; Kane, Michael; Malhotra, Jyoti; Aisner, Joseph; Kaufman, Howard L.; Ali, Siraj; Ross, Jeffrey; White, Eileen; Bhanot, Gyan; Ganesan, Shridar; Monette, Anne; Bergeron, Derek; Amor, Amira Ben; Meunier, Liliane; Caron, Christine; Morou, Antigoni; Kaufmann, Daniel; Liberman, Moishe; Jurisica, Igor; Mes-Masson, Anne-Marie; Hamzaoui, Kamel; Lapointe, Rejean; Mongan, Ann; Ku, Yuan-Chieh; Tom, Warren; Sun, Yongming; Pankov, Alex; Looney, Tim; Au-Young, Janice; Hyland, Fiona; Conroy, Jeff; Morrison, Carl; Glenn, Sean; Burgher, Blake; Ji, He; Gardner, Mark; Omilian, Angela R.; Bshara, Wiam; Angela, Omilian; Obeid, Joseph M.; Erdag, Gulsun; Smolkin, Mark E.; Deacon, Donna H.; Patterson, James W.; Chen, Lieping; Bullock, Timothy N.; Slingluff, Craig L.; Loffredo, John T.; Vuyyuru, Raja; Beyer, Sophie; Spires, Vanessa M.; Fox, Maxine; Ehrmann, Jon M.; Taylor, Katrina A.; Korman, Alan J.; Graziano, Robert F.; Page, David; Sanchez, Katherine; Martel, Maritza; De Macedo, Mariana Petaccia; Qin, Yong; Reuben, Alex; Spencer, Christine; Guindani, Michele; Racolta, Adriana; Kelly, Brian; Jones, Tobin; Polaske, Nathan; Theiss, Noah; Robida, Mark; Meridew, Jeffrey; Habensus, Iva; Zhang, Liping; Pestic-Dragovich, Lidija; Tang, Lei; Sullivan, Ryan; Olencki, Thomas; Hutson, Thomas; Roder, Joanna; Blackmon, Shauna; Roder, Heinrich; Stewart, John; Amin, Asim; Ernstoff, Marc S.; Clark, Joseph I.; Atkins, Michael B.; Sosman, Jeffrey; McDermott, David; Kluger, Harriet; Halaban, Ruth; Snzol, Mario; Asmellash, Senait; Steingrimsson, Arni; Wang, Chichung; Roman, Kristin; Clement, Amanda; Downing, Sean; Hoyt, Clifford; Harder, Nathalie; Schmidt, Guenter; Schoenmeyer, Ralf; Brieu, Nicolas; Yigitsoy, Mehmet; Madonna, Gabriele; Botti, Gerardo; Grimaldi, Antonio; Ascierto, Paolo A.; Huss, Ralf; Athelogou, Maria; Hessel, Harald; Buchner, Alexander; Stief, Christian; Binnig, Gerd; Kirchner, Thomas; Sellappan, Shankar; Thyparambil, Sheeno; Schwartz, Sarit; Cecchi, Fabiola; Nguyen, Andrew; Vaske, Charles; Hembrough, Todd; Spacek, Jan; Vocka, Michal; Zavadova, Eva; Skalova, Helena; Dundr, Pavel; Petruzelka, Lubos; Francis, Nicole; Tilman, Rau T.; Hartmann, Arndt; Netikova, Irena; Stump, Julia; Tufman, Amanda; Berger, Frank; Neuberger, Michael; Hatz, Rudolf; Lindner, Michael; Sanborn, Rachel E.; Handy, John; Huber, Rudolf M.; Winter, Hauke; Reu, Simone; Sun, Cheng; Xiao, Weihua; Tian, Zhigang; Arora, Kshitij S.; Desai, Niyati; Kulkarni, Anupriya; Rajurkar, Mihir; Rivera, Miguel; Deshpande, Vikram; Ting, David; Tsai, Katy; Nosrati, Adi; Goldinger, Simone; Hamid, Omid; Algazi, Alain; Tumeh, Paul; Hwang, Jimmy; Liu, Jacqueline; Chen, Lawrence; Dummer, Reinhard; Rosenblum, Michael; Daud, Adil; Tsao, Tsu-Shuen; Ashworth-Sharpe, Julia; Johnson, Donald; Bhaumik, Srabani; Bieniarz, Christopher; Couto, Joseph; Farrell, Michael; Ghaffari, Mahsa; Hubbard, Antony; Kosmeder, Jerome; Lee, Cleo; Marner, Erin; Uribe, Diana; Zhang, Hongjun; Zhang, Jian; Zhang, Wenjun; Zhu, Yifei; Morrison, Larry; Tsujikawa, Takahiro; Borkar, Rohan N.; Azimi, Vahid; Kumar, Sushil; Thibault, Guillaume; Mori, Motomi; El Rassi, Edward; Clayburgh, Daniel R.; Kulesz-Martin, Molly F.; Flint, Paul W.; Coussens, Lisa M.; Villabona, Lisa; Masucci, Giuseppe V.; Geiss, Gary; Birditt, Brian; Mei, Qian; Huang, Alan; Eagan, Maribeth A.; Ignacio, Eduardo; Elliott, Nathan; Dunaway, Dwayne; Jung, Jaemyeong; Merritt, Chris; Sprague, Isaac; Webster, Philippa; Liang, Yan; Wenthe, Jessica; Enblad, Gunilla; Karlsson, Hannah; Essand, Magnus; Savoldo, Barbara; Dotti, Gianpietro; Höglund, Martin; Brenner, Malcolm K.; Hagberg, Hans; Loskog, Angelica; Bernett, Matthew J.; Moore, Gregory L.; Hedvat, Michael; Bonzon, Christine; Chu, Seung; Rashid, Rumana; Avery, Kendra N.; Muchhal, Umesh; Desjarlais, John; Kraman, Matthew; Kmiecik, Katarzyna; Allen, Natalie; Faroudi, Mustapha; Zimarino, Carlo; Wydro, Mateusz; Doody, Jacqueline; Srinivasa, Sreesha P.; Govindappa, Nagaraja; Reddy, Praveen; Dubey, Aparajita; Periyasamy, Sankar; Adekandi, Madhukara; Dey, Chaitali; Joy, Mary; van Loo, Pieter Fokko; Veninga, Henrike; Shamsili, Setareh; Throsby, Mark; Dolstra, Harry; Bakker, Lex; Alva, Ajjai; Gschwendt, Juergen; Loriot, Yohann; Bellmunt, Joaquim; Feng, Dai; Poehlein, Christian; Powles, Thomas; Antonarakis, Emmanuel S.; Drake, Charles G.; Wu, Haiyan; De Bono, Johann; Bannerji, Rajat; Byrd, John; Gregory, Gareth; Opat, Stephen; Shortt, Jake; Yee, Andrew; Raje, Noopur; Thompson, Seth; Balakumaran, Arun; Kumar, Shaji; Rini, Brian I.; Choueiri, Toni; Mariani, Mariangela; Albiges, Laurence; Haanen, John B.; Larkin, James; Schmidinger, Manuela; Magazzù, Domenico; di Pietro, Alessandra; Motzer, Robert J.; Borch, Troels Holz; Kongsted, Per; Pedersen, Magnus; Met, Özcan; Boudadi, Karim; Wang, Hao; Vasselli, James; Baughman, Jan E.; Wigginton, Jon; Abdallah, Rehab; Ross, Ashley; Park, Jiwon; Grossenbacher, Steven; Luna, Jesus I.; Withers, Sita; Culp, William; Chen, Mingyi; Monjazeb, Arta; Kent, Michael S.; Chandran, Smita; Danforth, David; Yang, James; Klebanoff, Christopher; Goff, Stephanie; Paria, Biman; Sabesan, Arvind; Srivastava, Abhishek; Kammula, Udai; Richards, Jon; Faries, Mark; Andtbacka, Robert H. I.; Diaz, Luis A.; Le, Dung T.; Yoshino, Takayuki; André, Thierry; Bendell, Johanna; Koshiji, Minori; Zhang, Yayan; Kang, S Peter; Lam, Bao; Jäger, Dirk; Bauer, Todd M.; Wang, Judy S.; Lee, Jean K.; Manji, Gulam A.; Kudchadkar, Ragini; Kauh, John S.; Tang, Shande; Laing, Naomi; Falchook, Gerald; Garon, Edward B.; Halmos, Balazs; Rina, Hui; Leighl, Natasha; Lee, Sung Sook; Walsh, William; Dragnev, Konstanin; Piperdi, Bilal; Rodriguez, Luis Paz-Ares; Shinwari, Nabeegha; Wei, Ziewn; Maas, Mary L; Deeds, Michael; Armstrong, Adam; Peterson, Tim; Steinmetz, Sue; Herzog, Thomas; Backes, Floor J.; Copeland, Larry; Del Pilar Estevez Diz, Maria; Hare, Thomas W.; Huh, Warner; Kim, Byoung-Gie; Moore, Kathleen M.; Oaknin, Ana; Small, William; Tewari, Krishnansu S.; Monk, Bradley J.; Kamat, Ashish M.; Nam, Kijoeng; De Santis, Maria; Dreicer, Robert; Hahn, Noah M.; Perini, Rodolfo; Siefker-Radtke, Arlene; Sonpavde, Guru; de Wit, Ronald; Witjes, J. Alfred; Keefe, Stephen; Bajorin, Dean; Armand, Philippe; Kuruvilla, John; Moskowitz, Craig; Hamadani, Mehdi; Zinzani, Pier Luigi; Chlosta, Sabine; Bartlett, Nancy; Sabado, Rachel; Saenger, Yvonne; William, Loging; Donovan, Michael Joseph; Sacris, Erlinda; Mandeli, John; Salazar, Andres M.; Powderly, John; Brody, Joshua; Nemunaitis, John; Emens, Leisha; Patnaik, Amita; McCaffery, Ian; Miller, Richard; Laport, Ginna; Coveler, Andrew L.; Smith, David C.; Grilley-Olson, Juneko E.; Goel, Sanjay; Gardai, Shyra J.; Law, Che-Leung; Means, Gary; Manley, Thomas; Marrone, Kristen A.; Rosner, Gary; Anagnostou, Valsamo; Riemer, Joanne; Wakefield, Jessica; Zanhow, Cynthia; Baylin, Stephen; Gitlitz, Barbara; Brahmer, Julie; Signoretti, Sabina; Li, Wenting; Schloss, Charles; Michot, Jean-Marie; Ding, Wei; Christian, Beth; Marinello, Patricia; Shipp, Margaret; Najjar, Yana G.; Lin; Butterfield, Lisa H.; Tarhini, Ahmad A.; Davar, Diwakar; Zarour, Hassane; Rush, Elizabeth; Sander, Cindy; Fu, Siqing; Bauer, Todd; Molineaux, Chris; Bennett, Mark K.; Orford, Keith W.; Papadopoulos, Kyriakos P.; Padda, Sukhmani K.; Shah, Sumit A.; Colevas, A Dimitrios; Narayanan, Sujata; Fisher, George A.; Supan, Dana; Wakelee, Heather A.; Aoki, Rhonda; Pegram, Mark D.; Villalobos, Victor M.; Liu, Jie; Takimoto, Chris H.; Chao, Mark; Volkmer, Jens-Peter; Majeti, Ravindra; Weissman, Irving L.; Sikic, Branimir I.; Yu, Wendy; Conlin, Alison; Ruzich, Janet; Lewis, Stacy; Acheson, Anupama; Kemmer, Kathleen; Perlewitz, Kelly; Moxon, Nicole M.; Mellinger, Staci; McArthur, Heather; Juhler-Nøttrup, Trine; Desai, Jayesh; Markman, Ben; Sandhu, Shahneen; Gan, Hui; Friedlander, Michael L.; Tran, Ben; Meniawy, Tarek; Lundy, Joanne; Colyer, Duncan; Ameratunga, Malaka; Norris, Christie; Yang, Jason; Li, Kang; Wang, Lai; Luo, Lusong; Qin, Zhen; Mu, Song; Tan, Xuemei; Song, James; Millward, Michael; Katz, Matthew H. G.; Bauer, Todd W.; Varadhachary, Gauri R.; Acquavella, Nicolas; Merchant, Nipun; Petroni, Gina; Rahma, Osama E.; Chen, Mei; Song, Yang; Puhlmann, Markus; Khattri, Arun; Brisson, Ryan; Harvey, Christopher; Shah, Jatin; Mateos, Maria Victoria; Matsumoto, Morio; Blacklock, Hilary; Rocafiguera, Albert Oriol; Goldschmidt, Hartmut; Iida, Shinsuke; Yehuda, Dina Ben; Ocio, Enrique; Rodríguez-Otero, Paula; Jagannath, Sundar; Lonial, Sagar; Kher, Uma; San-Miguel, Jesus; de Oliveira, Moacyr Ribeiro; Yimer, Habte; Rifkin, Robert; Schjesvold, Fredrik; Ghori, Razi; Spreafico, Anna; Lee, Victor; Ngan, Roger K. C.; To, Ka Fai; Ahn, Myung Ju; Ng, Quan Sing; Lin, Jin-Ching; Swaby, Ramona F.; Gause, Christine; Saraf, Sanatan; Chan, Anthony T. C.; Lam, Elaine; Tannir, Nizar M.; Meric-Bernstam, Funda; Gross, Matt; MacKinnon, Andy; Whiting, Sam; Voss, Martin; Yu, Evan Y.; Albertini, Mark R.; Ranheim, Erik A.; Hank, Jacquelyn A.; Zuleger, Cindy; McFarland, Thomas; Collins, Jennifer; Clements, Erin; Weber, Sharon; Weigel, Tracey; Neuman, Heather; Hartig, Greg; Mahvi, David; Henry, MaryBeth; Gan, Jacek; Yang, Richard; Carmichael, Lakeesha; Kim, KyungMann; Gillies, Stephen D.; Sondel, Paul M.; Subbiah, Vivek; Noffsinger, Lori; Hendricks, Kyle; Bosch, Marnix; Lee, Jay M.; Lee, Mi-Heon; Goldman, Jonathan W.; Baratelli, Felicita E.; Schaue, Dorthe; Wang, Gerald; Rosen, Frances; Yanagawa, Jane; Walser, Tonya C.; Lin, Ying Q.; Adams, Sharon; Marincola, Franco M.; Tumeh, Paul C.; Abtin, Fereidoun; Suh, Robert; Reckamp, Karen; Wallace, William D.; Zeng, Gang; Elashoff, David A.; Sharma, Sherven; Dubinett, Steven M.; Pavlick, Anna C.; Gastman, Brian; Hanks, Brent; Keler, Tibor; Davis, Tom; Vitale, Laura A.; Sharon, Elad; Morishima, Chihiro; Cheever, Martin; Heery, Christopher R.; Kim, Joseph W.; Lamping, Elizabeth; Marte, Jennifer; McMahon, Sheri; Cordes, Lisa; Fakhrejahani, Farhad; Madan, Ravi; Salazar, Rachel; Zhang, Maggie; Helwig, Christoph; Gulley, James L; Li, Roger; Amrhein, John; Cohen, Zvi; Champagne, Monique; Kamat, Ashish; Aznar, M. Angela; Labiano, Sara; Diaz-Lagares, Angel; Esteller, Manel; Sandoval, Juan; Barbee, Susannah D.; Bellovin, David I.; Timmer, John C.; Wondyfraw, Nebiyu; Johnson, Susan; Park, Johanna; Chen, Amanda; Mkrtichyan, Mikayel; Razai, Amir S.; Jones, Kyle S.; Hata, Chelsie Y.; Gonzalez, Denise; Deveraux, Quinn; Eckelman, Brendan P.; Borges, Luis; Bhardwaj, Rukmini; Puri, Raj K.; Suzuki, Akiko; Leland, Pamela; Joshi, Bharat H.; Bartkowiak, Todd; Jaiswal, Ashvin; Ager, Casey; Ai, Midan; Budhani, Pratha; Chin, Renee; Hong, David; Curran, Michael; Hastings, William D.; Pinzon-Ortiz, Maria; Murakami, Masato; Dobson, Jason R.; Quinn, David; Wagner, Joel P.; Rong, Xianhui; Shaw, Pamela; Dammassa, Ernesta; Guan, Wei; Dranoff, Glenn; Cao, Alexander; Fulton, Ross B.; Leonardo, Steven; Fraser, Kathryn; Kangas, Takashi O.; Ottoson, Nadine; Bose, Nandita; Huhn, Richard D.; Graff, Jeremy; Lowe, Jamie; Gorden, Keith; Uhlik, Mark; O’Neill, Thomas; Widger, Jenifer; Crocker, Andrea; He, Li-Zhen; Weidlick, Jeffrey; Sundarapandiyan, Karuna; Ramakrishna, Venky; Storey, James; Thomas, Lawrence J.; Goldstein, Joel; Marsh, Henry C.; Grailer, Jamison; Gilden, Julia; Stecha, Pete; Garvin, Denise; Hartnett, Jim; Fan, Frank; Cong, Mei; Cheng, Zhi-jie Jey; Hinner, Marlon J.; Aiba, Rachida-Siham Bel; Schlosser, Corinna; Jaquin, Thomas; Allersdorfer, Andrea; Berger, Sven; Wiedenmann, Alexander; Matschiner, Gabriele; Schüler, Julia; Moebius, Ulrich; Rothe, Christine; Shane, Olwill A.; Horton, Brendan; Spranger, Stefani; Moreira, Dayson; Adamus, Tomasz; Zhao, Xingli; Swiderski, Piotr; Pal, Sumanta; Kortylewski, Marcin; Kosmides, Alyssa; Necochea, Kevin; Mahoney, Kathleen; Shukla, Sachet A.; Patsoukis, Nikolaos; Chaudhri, Apoorvi; Pham, Hung; Hua, Ping; Bu, Xia; Zhu, Baogong; Hacohen, Nir; Wu, Catherine J.; Fritsch, Edward; Boussiotis, Vassiliki; Freeman, Gordon J.; Moran, Amy E.; Polesso, Fanny; Lukaesko, Lisa; Rådestad, Emelie; Egevad, Lars; Sundberg, Berit; Henningsohn, Lars; Levitsky, Victor; Rafelson, William; Reagan, John L.; Fast, Loren; Sasikumar, Pottayil; Sudarshan, Naremaddepalli; Ramachandra, Raghuveer; Gowda, Nagesh; Samiulla, Dodheri; Chandrasekhar, Talapaneni; Adurthi, Sreenivas; Mani, Jiju; Nair, Rashmi; Dhudashia, Amit; Gowda, Nagaraj; Ramachandra, Murali; Sankin, Alexander; Gartrell, Benjamin; Cumberbatch, Kerwin; Huang, Hongying; Stern, Joshua; Schoenberg, Mark; Zang, Xingxing; Swanson, Ryan; Kornacker, Michael; Evans, Lawrence; Rickel, Erika; Wolfson, Martin; Valsesia-Wittmann, Sandrine; Shekarian, Tala; Simard, François; Nailo, Rodrigo; Dutour, Aurélie; Jallas, Anne-Catherine; Caux, Christophe; Marabelle, Aurélien
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    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
    (BioMed Central, 2016) Ager, Casey; Reilley, Matthew; Nicholas, Courtney; Bartkowiak, Todd; Jaiswal, Ashvin; Curran, Michael; Albershardt, Tina C.; Bajaj, Anshika; Archer, Jacob F.; Reeves, Rebecca S.; Ngo, Lisa Y.; Berglund, Peter; ter Meulen, Jan; Denis, Caroline; Ghadially, Hormas; Arnoux, Thomas; Chanuc, Fabien; Fuseri, Nicolas; Wilkinson, Robert W.; Wagtmann, Nicolai; Morel, Yannis; Andre, Pascale; Atkins, Michael B.; Carlino, Matteo S.; Ribas, Antoni; Thompson, John A.; Choueiri, Toni; Hodi, F. Stephen; Hwu, Wen-Jen; McDermott, David; Atkinson, Victoria; Cebon, Jonathan S.; Fitzharris, Bernie; Jameson, Michael B.; McNeil, Catriona; Hill, Andrew G.; Mangin, Eric; Ahamadi, Malidi; van Vugt, Marianne; van Zutphen, Mariëlle; Ibrahim, Nageatte; Long, Georgina V.; Gartrell, Robyn; Blake, Zoe; Simoes, Ines; Fu, Yichun; Saito, Takuro; Qian, Yingzhi; Lu, Yan; Saenger, Yvonne M.; Budhu, Sadna; De Henau, Olivier; Zappasodi, Roberta; Schlunegger, Kyle; Freimark, Bruce; Hutchins, Jeff; Barker, Christopher A.; Wolchok, Jedd D.; Merghoub, Taha; Burova, Elena; Allbritton, Omaira; Hong, Peter; Dai, Jie; Pei, Jerry; Liu, Matt; Kantrowitz, Joel; Lai, Venus; Poueymirou, William; MacDonald, Douglas; Ioffe, Ella; Mohrs, Markus; Olson, William; Thurston, Gavin; Capasso, Cristian; Frascaro, Federica; Carpi, Sara; Tähtinen, Siri; Feola, Sara; Fusciello, Manlio; Peltonen, Karita; Martins, Beatriz; Sjöberg, Madeleine; Pesonen, Sari; Ranki, Tuuli; Kyruk, Lukasz; Ylösmäki, Erkko; Cerullo, Vincenzo; Cerignoli, Fabio; Xi, Biao; Guenther, Garret; Yu, Naichen; Muir, Lincoln; Zhao, Leyna; Abassi, Yama; Cervera-Carrascón, Víctor; Siurala, Mikko; Santos, João; Havunen, Riikka; Parviainen, Suvi; Hemminki, Akseli; Dalgleish, Angus; Mudan, Satvinder; DeBenedette, Mark; Plachco, Ana; Gamble, Alicia; Grogan, Elizabeth W.; Krisko, John; Tcherepanova, Irina; Nicolette, Charles; Dhupkar, Pooja; Yu, Ling; Kleinerman, Eugenie S.; Gordon, Nancy; Grenga, Italia; Lepone, Lauren; Gameiro, Sofia; Knudson, Karin M.; Fantini, Massimo; Tsang, Kwong; Hodge, James; Donahue, Renee; Schlom, Jeffrey; Evans, Elizabeth; Bussler, Holm; Mallow, Crystal; Reilly, Christine; Torno, Sebold; Scrivens, Maria; Foster, Cathie; Howell, Alan; Balch, Leslie; Knapp, Alyssa; Leonard, John E.; Paris, Mark; Fisher, Terry; Hu-Lieskovan, Siwen; Smith, Ernest; Zauderer, Maurice; Fogler, William; Franklin, Marilyn; Thayer, Matt; Saims, Dan; Magnani, John L.; Gong, Jian; Gray, Michael; Fromm, George; de Silva, Suresh; Giffin, Louise; Xu, Xin; Rose, Jason; Schreiber, Taylor H.; Gameiro, Sofia R.; Clavijo, Paul E.; Allen, Clint T.; Hodge, James W.; Tsang, Kwong Y.; Grogan, Jane; Manieri, Nicholas; Chiang, Eugene; Caplazi, Patrick; Yadav, Mahesh; Hagner, Patrick; Chiu, Hsiling; Waldman, Michelle; Klippel, Anke; Thakurta, Anjan; Pourdehnad, Michael; Gandhi, Anita; Henrich, Ian; Quick, Laura; Young, Rob; Chou, Margaret; Hotson, Andrew; Willingham, Stephen; Ho, Po; Choy, Carmen; Laport, Ginna; McCaffery, Ian; Miller, Richard; Tipton, Kimberly A.; Wong, Kenneth R.; Singson, Victoria; Wong, Chihunt; Chan, Chanty; Huang, Yuanhiu; Liu, Shouchun; Richardson, Jennifer H.; Kavanaugh, W. Michael; West, James; Irving, Bryan A.; Jaini, Ritika; Loya, Matthew; Eng, Charis; Johnson, Melissa L.; Adjei, Alex A.; Opyrchal, Mateusz; Ramalingam, Suresh; Janne, Pasi A.; Dominguez, George; Gabrilovich, Dmitry; de Leon, Laura; Hasapidis, Jeannette; Diede, Scott J.; Ordentlich, Peter; Cruickshank, Scott; Meyers, Michael L.; Hellmann, Matthew D.; Kalinski, Pawel; Zureikat, Amer; Edwards, Robert; Muthuswamy, Ravi; Obermajer, Nataša; Urban, Julie; Butterfield, Lisa H.; Gooding, William; Zeh, Herbert; Bartlett, David; Zubkova, Olga; Agapova, Larissa; Kapralova, Marina; Krasovskaia, Liudmila; Ovsepyan, Armen; Lykov, Maxim; Eremeev, Artem; Bokovanov, Vladimir; Grigoryeva, Olga; Karpov, Andrey; Ruchko, Sergey; Shuster, Alexandr; Khalil, Danny N.; Campesato, Luis Felipe; Li, Yanyun; Lazorchak, Adam S.; Patterson, Troy D.; Ding, Yueyun; Sasikumar, Pottayil; Sudarshan, Naremaddepalli; Gowda, Nagaraj; Ramachandra, Raghuveer; Samiulla, Dodheri; Giri, Sanjeev; Eswarappa, Rajesh; Ramachandra, Murali; Tuck, David; Wyant, Timothy; Leshem, Jasmin; Liu, Xiu-fen; Bera, Tapan; Terabe, Masaki; Bossenmaier, Birgit; Niederfellner, Gerhard; Reiter, Yoram; Pastan, Ira; Xia, Leiming; Xia, Yang; Hu, Yangyang; Wang, Yi; Bao, Yangyi; Dai, Fu; Huang, Shiang; Hurt, Elaine; Hollingsworth, Robert E.; Lum, Lawrence G.; Chang, Alfred E.; Wicha, Max S.; Li, Qiao; Mace, Thomas; Makhijani, Neil; Talbert, Erin; Young, Gregory; Guttridge, Denis; Conwell, Darwin; Lesinski, Gregory B.; Gonzales, Rodney JM Macedo; Huffman, Austin P.; Wang, Ximi K.; Reshef, Ran; MacKinnon, Andy; Chen, Jason; Gross, Matt; Marguier, Gisele; Shwonek, Peter; Sotirovska, Natalija; Steggerda, Susanne; Parlati, Francesco; Makkouk, Amani; Bennett, Mark K.; Emberley, Ethan; Huang, Tony; Li, Weiqun; Neou, Silinda; Pan, Alison; Zhang, Jing; Zhang, Winter; Marshall, Netonia; Marron, Thomas U.; Agudo, Judith; Brown, Brian; Brody, Joshua; McQuinn, Christopher; Farren, Matthew; Komar, Hannah; Shakya, Reena; Ludwug, Thomas; Morillon, Y. Maurice; Hammond, Scott A.; Greiner, John W.; Nath, Pulak R.; Schwartz, Anthony L.; Maric, Dragan; Roberts, David D.; Naing, Aung; Papadopoulos, Kyriakos P.; Autio, Karen A.; Wong, Deborah J.; Patel, Manish; Falchook, Gerald; Pant, Shubham; Ott, Patrick A.; Whiteside, Melinda; Patnaik, Amita; Mumm, John; Janku, Filip; Chan, Ivan; Bauer, Todd; Colen, Rivka; VanVlasselaer, Peter; Brown, Gail L.; Tannir, Nizar M.; Oft, Martin; Infante, Jeffrey; Lipson, Evan; Gopal, Ajay; Neelapu, Sattva S.; Armand, Philippe; Spurgeon, Stephen; Leonard, John P.; Sanborn, Rachel E.; Melero, Ignacio; Gajewski, Thomas F.; Maurer, Matthew; Perna, Serena; Gutierrez, Andres A.; Clynes, Raphael; Mitra, Priyam; Suryawanshi, Satyendra; Gladstone, Douglas; Callahan, Margaret K.; Crooks, James; Brown, Sheila; Gauthier, Audrey; de Boisferon, Marc Hillairet; MacDonald, Andrew; Brunet, Laura Rosa; Rothwell, William T.; Bell, Peter; Wilson, James M.; Sato-Kaneko, Fumi; Yao, Shiyin; Zhang, Shannon S.; Carson, Dennis A.; Guiducci, Cristina; Coffman, Robert L.; Kitaura, Kazutaka; Matsutani, Takaji; Suzuki, Ryuji; Hayashi, Tomoko; Cohen, Ezra E. W.; Schaer, David; Li, Yanxia; Dobkin, Julie; Amatulli, Michael; Hall, Gerald; Doman, Thompson; Manro, Jason; Dorsey, Frank Charles; Sams, Lillian; Holmgaard, Rikke; Persaud, Krishnadatt; Ludwig, Dale; Surguladze, David; Kauh, John S.; Novosiadly, Ruslan; Kalos, Michael; Driscoll, Kyla; Pandha, Hardev; Ralph, Christy; Harrington, Kevin; Curti, Brendan; Akerley, Wallace; Gupta, Sumati; Melcher, Alan; Mansfield, David; Kaufman, David R.; Schmidt, Emmett; Grose, Mark; Davies, Bronwyn; Karpathy, Roberta; Shafren, Darren; Shamalov, Katerina; Cohen, Cyrille; Sharma, Naveen; Allison, James; Shekarian, Tala; Valsesia-Wittmann, Sandrine; Caux, Christophe; Marabelle, Aurelien; Slomovitz, Brian M.; Moore, Kathleen M.; Youssoufian, Hagop; Posner, Marshall; Tewary, Poonam; Brooks, Alan D.; Xu, Ya-Ming; Wijeratne, Kithsiri; Gunatilaka, Leslie A. 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    Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy
    (Nature Publishing Group, 2016) Bellmunt, Joaquim; Zhou, Chensheng Willa; Mullane, Stephanie A; Werner, Lillian; Taplin, Mary-Ellen; Fay, André P; Choueiri, Toni; Orsola, Anna; Takeda, David; Hahn, William; Kim, Jaegil; Sonpavde, Guru; Bowden, Michaela
    Background: Tumour expression of selected microRNAs (miRs) correlates with cisplatin efficacy in multiple cancers. We investigated the role of selected miRs in patients receiving cisplatin-based therapy for advanced urothelial carcinoma (UC). Methods: RNA was extracted from formalin-fixed paraffin-embedded tumour from 83 advanced UC patients who received cisplatin. A miR panel based on relevance for platinum sensitivity and UC was studied by quantitative reverse transcription quantitative PCR (RT–qPCR). Association of progression-free survival (PFS) with miR expression was analysed using cox regression. Selected TFs were chosen by association with the panel of miRs using the Transcription Regulation algorithm (GeneGo MetaCore+MetaDrug version 6.23 build 67496). Bladder cancer (BC) cell lines were used to investigate the previously described role of miR-21 mediating cisplatin sensitivity. Results: The 83 patients had a median PFS of 8 months. In multivariate analysis, higher levels of E2F1 (P=0.01, HR: 1.95 (1.14, 3.33)), miR-21 (P=0.01, HR: 2.01 (1.17, 3.45)) and miR-372 (P=0.05, HR: 1.70 (1.00, 2.89)) were associated with a shorter PFS. In the 8 BC cell lines, miR-21 was not shown to be necessary nor sufficient for modulating cisplatin sensitivity. Conclusions: In metastatic UC patients treated with cisplatin-based therapy, high primary tumour levels of E2F1, miR-21 and miR-372 are associated with poor PFS independent of clinical prognostic factors. The in vitro study could not confirm miR-21 levels role in modulating platinum sensitivity.
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    High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes
    (Public Library of Science, 2015) Anderson, Joshua C.; Willey, Christopher D.; Mehta, Amitkumar; Welaya, Karim; Chen, Dongquan; Duarte, Christine W.; Ghatalia, Pooja; Arafat, Waleed; Madan, Ankit; Sudarshan, Sunil; Naik, Gurudatta; Grizzle, William E.; Choueiri, Toni; Sonpavde, Guru
    Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is lacking. Thus, kinomic profiling of CC-RCC may assist in devising a classification system associated with clinical outcomes, and help identify potential therapeutic targets. Fresh frozen CC-RCC tumor lysates from 41 clinically annotated patients who had localized disease at diagnosis were kinomically profiled using the PamStation®12 high-content phospho-peptide substrate microarray system (PamGene International). Twelve of these patients also had matched normal kidneys available that were also profiled. Unsupervised hierarchical clustering and supervised comparisons based on tumor vs. normal kidney and clinical outcome (tumor recurrence) were performed and coupled with advanced network modeling and upstream kinase prediction methods. Unsupervised clustering analysis of localized CC-RCC tumors identified 3 major kinomic groups associated with inflammation (A), translation initiation (B), and immune response and cell adhesions (C) processes. Potential driver kinases implicated include PFTAIRE (PFTK1), PKG1, and SRC, which were identified in groups A, B, and C, respectively. Of the 9 patients who had tumor recurrence, only one was found in Group B. Supervised analysis showed decreased kinase activity of CDK1 and RSK1-4 substrates in those which progressed compared to others. Twelve tumors with matching normal renal tissue implicated increased PIM’s and MAPKAPK’s in tumors compared to adjacent normal renal tissue. As such, comprehensive kinase profiling of CC-RCC tumors could provide a functional classification strategy for patients with localized disease and identify potential therapeutic targets.
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    Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma
    (Nature Publishing Group, 2016) Mullane, Stephanie A.; Werner, Lillian; Rosenberg, Jonathan; Signoretti, Sabina; Callea, Marcella; Choueiri, Toni; Freeman, Gordon; Bellmunt, Joaquim
    Metastatic urothelial carcinoma (mUC) has a very high mutational rate and is associated with an APOBEC mutation signature. We examined the correlation of APOBEC expression with overall survival (OS) and PD-L1 expression in a cohort of 73 mUC patients. mRNA expression of APOBEC3 family of genes (A3A, A3B, A3C, A3F_a, A3F_b, A3G, A3H) was measured using Nanostring. PD-L1 expression, evaluated by immunohistochemistry, on tumor infiltrating mononuclear cells (TIMCs) and tumor cells was scored from 0 to 4, with 2–4 being positive. Wilcoxon’s non-parametric tests assessed the association of APOBEC and PD-L1. The Cox regression model assessed the association of APOBEC with OS. All APOBEC genes were expressed in mUC. Increased A3A, A3D, and A3H expression associates with PD-L1 positive TIMCs (p = 0.0009, 0.009, 0.06). Decreased A3B expression was marginally associated with PD-L1 positive TIMCs expression (p = 0.05). Increased A3F_a and A3F_b expression was associated with increased expression of PD-L1 on tumor cells (p = 0.05). Increased expression of A3D and A3H was associated with longer OS (p = 0.0009). Specific APOBEC genes have different effects on mUC in terms of survival and PD-L1 expression. A3D and A3H may have the most important role in mUC as they are associated with OS and PD-L1 TIMC expression.