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Scarfo, Irene

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Scarfo

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Irene

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Scarfo, Irene
Author's Publications: search.filters.isAuthorOfPublication.29b6edf3-a682-42d8-a81e-5a4392b62b44

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    The heterogeneous landscape of ALK negative ALCL
    (Impact Journals LLC, 2017) Mereu, Elisabetta; Pellegrino, Elisa; Scarfo, Irene; Inghirami, Giorgio; Piva, Roberto
    Anaplastic Large Cell Lymphoma (ALCL) is a clinical and biological heterogeneous disease including systemic ALK positive and ALK negative entities. Whereas ALK positive ALCLs are molecularly characterized and readily diagnosed, specific immunophenotypic or genetic features to define ALK negative ALCL are missing, and their distinction from other T-cell non-Hodgkin lymphomas (T-NHLs) can be controversial. In recent years, great advances have been made in dissecting the heterogeneity of ALK negative ALCLs and in providing new diagnostic and treatment options for these patients. A new revision of the World Health Organization (WHO) classification promoted ALK negative ALCL to a definite entity that includes cytogenetic subsets with prognostic implications. However, a further understanding of the genetic landscape of ALK negative ALCL is required to dictate more effective therapeutic strategies specifically tailored for each subgroup of patients.
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    Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment
    (BioMed Central, 2017) Scarfo, Irene; Maus, Marcela
    Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches.