Person:
Yung, Andrea R.

Profile Picture

Email Address

AA Acceptance Date

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Yung

First Name

Andrea R.

Name

Yung, Andrea R.

Filters

2013 - 20183

Settings

Author's Publications: search.filters.isAuthorOfPublication.39a4711e-6f2d-4ed2-b64a-883153d15247

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    How to survive a nerve-wracking journey
    (eLife Sciences Publications, Ltd, 2013) Yung, Andrea R.; Goodrich, Lisa
    When the axons that carry signals to muscles are growing, they rely on help from Frizzled3—a protein that is known to perform a number of other important functions in cells—to reach their final destination.
  • Thumbnail Image
    Publication
    Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord
    (BioMed Central, 2016) Junge, Harald J.; Yung, Andrea R.; Goodrich, Lisa; Chen, Zhe
    Background: Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during development. In the developing spinal cord, neuroprogenitors first undergo radial migration within the ventricular zone. Differentiated neurons continue to migrate tangentially before reaching the final positions. The molecular pathways that regulate these migration processes remain largely unknown. Our previous study suggests that the DCC receptor is important for the migration of the dorsal spinal cord progenitors and interneurons. In this study, we determined the involvement of the Netrin1 ligand and the ROBO3 coreceptor in the migration. Results: By pulse labeling neuroprogenitors with electroporation, we examined their radial migration in Netrin1 (Ntn1), Dcc, and Robo3 knockout mice. We found that all three mutants exhibit delayed migration. Furthermore, using immunohistochemistry of the BARHL2 interneuron marker, we found that the mediolateral and dorsoventral migration of differentiated dorsal interneurons is also delayed. Together, our results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord. Conclusions: Netrin1, DCC, and ROBO3 have been extensively studied for their functions in regulating axon guidance in the spinal commissural interneurons. We reveal that during earlier development of dorsal interneurons including commissural neurons, these molecules play an important role in promoting cell migration. Electronic supplementary material The online version of this article (doi:10.1186/s13064-016-0074-x) contains supplementary material, which is available to authorized users.
  • Thumbnail Image
    Publication
    Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS
    (2018) Yung, Andrea R.; Druckenbrod, Noah R.; Cloutier, Jean-François; Wu, Zhuhao; Tessier-Lavigne, Marc; Goodrich, Lisa
    SUMMARY During brainstem development, newborn neurons originating from the rhombic lip embark on exceptionally long migrations to generate nuclei important for audition, movement, and respiration. Along the way, this highly motile population passes several cranial nerves yet remains confined to the CNS. We found that Ntn1 accumulates beneath the pial surface separating the CNS from the PNS, with gaps at nerve entry sites. In mice null for Ntn1 or its receptor DCC, hindbrain neurons enter cranial nerves and migrate into the periphery. CNS neurons also escape when Ntn1 is selectively lost from the sub-pial region (SPR), and conversely, expression of Ntn1 throughout the mutant hindbrain can prevent their departure. These findings identify a permissive role for Ntn1 in maintaining the CNS-PNS boundary. We propose that Ntn1 confines rhombic lip-derived neurons by providing a preferred substrate for tangentially migrating neurons in the SPR, preventing their entry into nerve roots.