Intensive care unit (ICU) sepsis in patients is a common clinical practice primarily in the tertiary care settings. Multidrug resistance to pathogens causing ICU sepsis is widespread, and it poses a severe threat to physicians in terms of managing their patients. At times, physicians get exposed to a pathogen they have never encountered before. Burkholderia cepacia infection in immunocompetent patients is rare. This infection is common in patients with immunocompromised immunity and cystic fibrosis. We report a case of a 34-year-old female who was diagnosed with ceftazidime-resistant Burkholderia cepacia in an ICU setting. This is the first case of drug-resistant Burkholderia cepacia reported from Pakistan.
